CIDeRplusGeneral Information:
| Id: | 5,074 (click here to show other Interactions for entry) |
| Diseases: |
Diabetes mellitus, type II
- [OMIM]
Insulin resistance |
| Rattus norvegicus | |
| male | |
| article | |
| Reference: | Madiraju AK et al.(2014) Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase Nature 510: 542-546 [PMID: 24847880] |
Interaction Information:
| Comment | Given that acute and chronic metformin treatment increased the cytoplasmic redox state and decreased the mitochondrial redox state, the study considered that metformin may block one of the two main redox shuttle systems, the malate‚Äďaspartate and glycerophosphate shuttles. Guanides/biguanides did not alter the activity of purified, recombinant cytosolic glycerophosphate dehydrogenase (cGPD). In contrast, all guanides/biguanides inhibited mitochondrial GPD (mGPD) activity by30‚Äď50% in rat mitochondrial lysates. |
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Formal Description Interaction-ID: 49892 |
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