General Information:

Id: 5,024
Diseases: Neurological
Homo sapiens
article
Reference: Furukawa H et al.(2005) Subunit arrangement and function in NMDA receptors Nature 438: 185-192 [PMID: 16281028]

Interaction Information:

Comment NMDA (N-methyl-D-aspartate) receptors are heteromeric ion channels that for activation require binding of glycine and glutamate to the NR1 and NR2 subunits, respectively. NMDA receptor function is characterized by slow channel opening and deactivation, and the resulting influx of cations initiates signal transduction cascades that are crucial to higher functions including learning and memory.
Formal Description
Interaction-ID: 49586

drug/chemical compound

Glycine

interacts (colocalizes) with

gene/protein

GRIN1

Drugbank entries Show/Hide entries for Glycine or GRIN1
Comment NMDA (N-methyl-D-aspartate) receptors are heteromeric ion channels that for activation require binding of glycine and glutamate to the NR1 and NR2 subunits, respectively. NMDA receptor function is characterized by slow channel opening and deactivation, and the resulting influx of cations initiates signal transduction cascades that are crucial to higher functions including learning and memory.
Formal Description
Interaction-ID: 53420

drug/chemical compound

Glutamate

interacts (colocalizes) with

gene/protein

GRIN2A

Drugbank entries Show/Hide entries for GRIN2A