General Information:

Id: 5,013
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Homo sapiens
article
Reference: Millet L et al.(1998) Catecholamine effects on lipolysis and blood flow in human abdominal and femoral adipose tissue J. Appl. Physiol. 85: 181-188 [PMID: 9655773]

Interaction Information:

Comment Isoproterenol perfusion increased extracellular glycerol levels, but no differences were found by gender or fat-deposit site.
Formal Description
Interaction-ID: 49495

drug/chemical compound

Isoproterenol

increases_quantity of

drug/chemical compound

Glycerol

extracellular, in abdominal adipose tissue, in femoral adipose tissue
Drugbank entries Show/Hide entries for Isoproterenol or Glycerol
Comment Isoproterenol induced a greater increase in local blood flow in femoral adipose tissue than in abdominal adipose tissue in both genders.
Formal Description
Interaction-ID: 49497

drug/chemical compound

Isoproterenol

increases_activity of

phenotype

increased blood flow

in abdominal adipose tissue, in femoral adipose tissue
Drugbank entries Show/Hide entries for Isoproterenol
Comment Epinephrine and norepinephrine perfusion increased extracellular glycerol and reduced blood flow. No major differences were found according to gender and fat-deposit site.
Formal Description
Interaction-ID: 49499

drug/chemical compound

Adrenaline

increases_quantity of

drug/chemical compound

Glycerol

extracellular, in abdominal adipose tissue, in femoral adipose tissue
Drugbank entries Show/Hide entries for
Comment Epinephrine and norepinephrine perfusion increased extracellular glycerol and reduced blood flow. No major differences were found according to gender and fat-deposit site.
Formal Description
Interaction-ID: 49500

drug/chemical compound

Noradrenaline

increases_quantity of

drug/chemical compound

Glycerol

extracellular, in abdominal adipose tissue, in femoral adipose tissue
Drugbank entries Show/Hide entries for
Comment Epinephrine and norepinephrine perfusion increased extracellular glycerol and reduced blood flow. No major differences were found according to gender and fat-deposit site.
Formal Description
Interaction-ID: 49501

drug/chemical compound

Adrenaline

increases_activity of

phenotype

decreased blood flow

in abdominal adipose tissue, in femoral adipose tissue
Comment Epinephrine and norepinephrine perfusion increased extracellular glycerol and reduced blood flow. No major differences were found according to gender and fat-deposit site.
Formal Description
Interaction-ID: 49502

drug/chemical compound

Noradrenaline

increases_activity of

phenotype

decreased blood flow

in abdominal adipose tissue, in femoral adipose tissue
Comment As expected, change from supine to head-up posture (active tilt) induced a significant activation of the sympathetic nervous system (SNS), as assessed by the increase in plasma norepinephrine levels. Active tilt increased plasma glycerol, free fatty acid, norepinephrine levels, and extracellular glycerol concentration to the same extent whatever the gender and fat deposit.
Formal Description
Interaction-ID: 49504

tissue/cell line

sympathetic nervous system

increases_quantity of

drug/chemical compound

Glycerol

extracellular, in abdominal adipose tissue, in femoral adipose tissue, in blood plasma
Drugbank entries Show/Hide entries for
Comment As expected, change from supine to head-up posture (active tilt) induced a significant activation of the sympathetic nervous system (SNS), as assessed by the increase in plasma norepinephrine levels. Active tilt increased plasma glycerol, free fatty acid, norepinephrine levels, and extracellular glycerol concentration to the same extent whatever the gender and fat deposit.
Formal Description
Interaction-ID: 49505

tissue/cell line

sympathetic nervous system

increases_quantity of

drug/chemical compound

Fatty acid

in blood plasma
Comment As expected, change from supine to head-up posture (active tilt) induced a significant activation of the sympathetic nervous system (SNS), as assessed by the increase in plasma norepinephrine levels. Active tilt increased plasma glycerol, free fatty acid, norepinephrine levels, and extracellular glycerol concentration to the same extent whatever the gender and fat deposit.
Formal Description
Interaction-ID: 49506

tissue/cell line

sympathetic nervous system

increases_quantity of

drug/chemical compound

Noradrenaline

in blood plasma