CIDeRplusGeneral Information:
| Id: | 4,940 |
| Diseases: |
Diabetes mellitus, type II
- [OMIM]
Insulin resistance |
| Homo sapiens | |
| article | |
| Reference: | Mittelstrass K et al.(2011) Discovery of sexual dimorphisms in metabolic and genetic biomarkers PLoS Genet. 7 [PMID: 21852955] |
Interaction Information:
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The linear regression analysis showed that the concentrations of most amino acids were significantly higher in males except for the concentrations of glycine and serine which displayed higher concentrations in females. |
|
Formal Description Interaction-ID: 48832 |
phenotype sex affects_quantity of drug/chemical compound Leucine/Isoleucine |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The linear regression analysis showed that the concentrations of most amino acids were significantly higher in males except for the concentrations of glycine and serine which displayed higher concentrations in females. |
|
Formal Description Interaction-ID: 49023 |
phenotype sex affects_quantity of drug/chemical compound |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The linear regression analysis showed that the concentrations of most amino acids were significantly higher in males except for the concentrations of glycine and serine which displayed higher concentrations in females. |
|
Formal Description Interaction-ID: 49024 |
phenotype sex affects_quantity of drug/chemical compound |
| Drugbank entries | Show/Hide entries for |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The linear regression analysis showed that the concentrations of most amino acids were significantly higher in males except for the concentrations of glycine and serine which displayed higher concentrations in females. |
|
Formal Description Interaction-ID: 49025 |
phenotype sex affects_quantity of drug/chemical compound |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The linear regression analysis showed that the concentrations of most amino acids were significantly higher in males except for the concentrations of glycine and serine which displayed higher concentrations in females. |
|
Formal Description Interaction-ID: 49026 |
phenotype sex affects_quantity of drug/chemical compound |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The linear regression analysis showed that the concentrations of most amino acids were significantly higher in males except for the concentrations of glycine and serine which displayed higher concentrations in females. |
|
Formal Description Interaction-ID: 49027 |
phenotype sex affects_quantity of drug/chemical compound |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The linear regression analysis showed that the concentrations of most amino acids were significantly higher in males except for the concentrations of glycine and serine which displayed higher concentrations in females. |
|
Formal Description Interaction-ID: 49028 |
phenotype sex affects_quantity of drug/chemical compound |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The linear regression analysis showed that the concentrations of most amino acids were significantly higher in males except for the concentrations of glycine and serine which displayed higher concentrations in females. |
|
Formal Description Interaction-ID: 49029 |
phenotype sex affects_quantity of drug/chemical compound |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The linear regression analysis showed that the concentrations of most amino acids were significantly higher in males except for the concentrations of glycine and serine which displayed higher concentrations in females. |
|
Formal Description Interaction-ID: 49031 |
phenotype sex affects_quantity of drug/chemical compound |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The linear regression analysis showed that the concentrations of most amino acids were significantly higher in males except for the concentrations of glycine and serine which displayed higher concentrations in females. |
|
Formal Description Interaction-ID: 49032 |
phenotype sex affects_quantity of drug/chemical compound |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The linear regression analysis showed that the concentrations of most amino acids were significantly higher in males except for the concentrations of glycine and serine which displayed higher concentrations in females. |
|
Formal Description Interaction-ID: 49033 |
phenotype sex affects_quantity of drug/chemical compound |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The linear regression analysis showed that the concentrations of most amino acids were significantly higher in males except for the concentrations of glycine and serine which displayed higher concentrations in females. |
|
Formal Description Interaction-ID: 49034 |
phenotype sex affects_quantity of drug/chemical compound |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The levels of most serum acylcarnitines were significantly higher in males compared to females. |
|
Formal Description Interaction-ID: 49035 |
phenotype sex affects_quantity of drug/chemical compound Stearoylcarnitine |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The levels of most serum acylcarnitines were significantly higher in males compared to females. |
|
Formal Description Interaction-ID: 49037 |
phenotype sex affects_quantity of drug/chemical compound Acylcarnitine C18:2 |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The levels of most serum acylcarnitines were significantly higher in males compared to females. |
|
Formal Description Interaction-ID: 49038 |
phenotype sex affects_quantity of drug/chemical compound |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The levels of most serum acylcarnitines were significantly higher in males compared to females. |
|
Formal Description Interaction-ID: 49039 |
phenotype sex affects_quantity of drug/chemical compound Lauroylcarnitine |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The levels of most serum acylcarnitines were significantly higher in males compared to females. |
|
Formal Description Interaction-ID: 49040 |
phenotype sex affects_quantity of drug/chemical compound Valerylcarnitine |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The levels of most serum acylcarnitines were significantly higher in males compared to females. |
|
Formal Description Interaction-ID: 49043 |
phenotype sex affects_quantity of drug/chemical compound Acylcarnitine C14:2 |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The levels of most serum acylcarnitines were significantly higher in males compared to females. |
|
Formal Description Interaction-ID: 49044 |
phenotype sex affects_quantity of drug/chemical compound |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The levels of most serum acylcarnitines were significantly higher in males compared to females. |
|
Formal Description Interaction-ID: 49046 |
phenotype sex affects_quantity of drug/chemical compound Acylcarnitine C14:2-OH |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The levels of most serum acylcarnitines were significantly higher in males compared to females. |
|
Formal Description Interaction-ID: 49048 |
phenotype sex affects_quantity of drug/chemical compound Acylcarnitine C16:2 |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The levels of most serum acylcarnitines were significantly higher in males compared to females. |
|
Formal Description Interaction-ID: 49049 |
phenotype sex affects_quantity of drug/chemical compound |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The levels of most serum acylcarnitines were significantly higher in males compared to females. |
|
Formal Description Interaction-ID: 49050 |
phenotype sex affects_quantity of drug/chemical compound Acylcarnitine C10:1 |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The levels of most serum acylcarnitines were significantly higher in males compared to females. |
|
Formal Description Interaction-ID: 49051 |
phenotype sex affects_quantity of drug/chemical compound Decanoylcarnitine |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The levels of most serum acylcarnitines were significantly higher in males compared to females. |
|
Formal Description Interaction-ID: 49052 |
phenotype sex affects_quantity of drug/chemical compound Acylcarnitine C12:1 |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The levels of most serum acylcarnitines were significantly higher in males compared to females. |
|
Formal Description Interaction-ID: 49053 |
phenotype sex affects_quantity of drug/chemical compound Acylcarnitine C18:1 |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The levels of most serum acylcarnitines were significantly higher in males compared to females. |
|
Formal Description Interaction-ID: 49054 |
phenotype sex affects_quantity of drug/chemical compound |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The levels of most serum acylcarnitines were significantly higher in males compared to females. |
|
Formal Description Interaction-ID: 49055 |
phenotype sex affects_quantity of drug/chemical compound |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The levels of most serum acylcarnitines were significantly higher in males compared to females. |
|
Formal Description Interaction-ID: 49056 |
phenotype sex affects_quantity of drug/chemical compound Nonanoylcarnitine |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The levels of most serum acylcarnitines were significantly higher in males compared to females. |
|
Formal Description Interaction-ID: 49057 |
phenotype sex affects_quantity of drug/chemical compound Tetradecanoylcarnitine |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The levels of most serum acylcarnitines were significantly higher in males compared to females. |
|
Formal Description Interaction-ID: 49059 |
phenotype sex affects_quantity of drug/chemical compound Acylcarnitine C10:2 |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The levels of most serum acylcarnitines were significantly higher in males compared to females. |
|
Formal Description Interaction-ID: 49060 |
phenotype sex affects_quantity of drug/chemical compound Acylcarnitine C4:1 |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The concentrations of phosphatidylcholines tended to be significantly lower in males compared to females. The most significant difference between gender could be seen for the phosphatidylcholine PC aa C32:3. |
|
Formal Description Interaction-ID: 49062 |
phenotype sex affects_quantity of drug/chemical compound PC aa C32:3 |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The concentrations of phosphatidylcholines tended to be significantly lower in males compared to females. The most significant difference between gender could be seen for the phosphatidylcholine PC aa C32:3. |
|
Formal Description Interaction-ID: 49075 |
phenotype sex affects_quantity of drug/chemical compound PC aa C28:1 |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The concentrations of phosphatidylcholines tended to be significantly lower in males compared to females. The most significant difference between gender could be seen for the phosphatidylcholine PC aa C32:3. |
|
Formal Description Interaction-ID: 49076 |
phenotype sex affects_quantity of drug/chemical compound PC aa C38:3 |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The concentrations of phosphatidylcholines tended to be significantly lower in males compared to females. The most significant difference between gender could be seen for the phosphatidylcholine PC aa C32:3. |
|
Formal Description Interaction-ID: 49077 |
phenotype sex affects_quantity of drug/chemical compound PC aa C34:4 |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The concentrations of phosphatidylcholines tended to be significantly lower in males compared to females. The most significant difference between gender could be seen for the phosphatidylcholine PC aa C32:3. |
|
Formal Description Interaction-ID: 49078 |
phenotype sex affects_quantity of drug/chemical compound PC aa C36:6 |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The concentrations of phosphatidylcholines tended to be significantly lower in males compared to females. The most significant difference between gender could be seen for the phosphatidylcholine PC aa C32:3. |
|
Formal Description Interaction-ID: 49079 |
phenotype sex affects_quantity of drug/chemical compound PC aa C32:2 |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The concentrations of phosphatidylcholines tended to be significantly lower in males compared to females. The most significant difference between gender could be seen for the phosphatidylcholine PC aa C32:3. |
|
Formal Description Interaction-ID: 49080 |
phenotype sex affects_quantity of drug/chemical compound PC aa C36:2 |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The concentrations of phosphatidylcholines tended to be significantly lower in males compared to females. The most significant difference between gender could be seen for the phosphatidylcholine PC aa C32:3. |
|
Formal Description Interaction-ID: 49081 |
phenotype sex affects_quantity of drug/chemical compound PC aa C38:0 |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The concentrations of phosphatidylcholines tended to be significantly lower in males compared to females. The most significant difference between gender could be seen for the phosphatidylcholine PC aa C32:3. |
|
Formal Description Interaction-ID: 49082 |
phenotype sex affects_quantity of drug/chemical compound PC aa C30:0 |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The concentrations of phosphatidylcholines tended to be significantly lower in males compared to females. The most significant difference between gender could be seen for the phosphatidylcholine PC aa C32:3. |
|
Formal Description Interaction-ID: 49083 |
phenotype sex affects_quantity of drug/chemical compound PC aa C38:4 |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The concentrations of phosphatidylcholines tended to be significantly lower in males compared to females. The most significant difference between gender could be seen for the phosphatidylcholine PC aa C32:3. |
|
Formal Description Interaction-ID: 49084 |
phenotype sex affects_quantity of drug/chemical compound PC aa C36:0 |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The concentrations of phosphatidylcholines tended to be significantly lower in males compared to females. The most significant difference between gender could be seen for the phosphatidylcholine PC aa C32:3. |
|
Formal Description Interaction-ID: 49085 |
phenotype sex affects_quantity of drug/chemical compound PC aa C36:1 |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The concentrations of phosphatidylcholines tended to be significantly lower in males compared to females. The most significant difference between gender could be seen for the phosphatidylcholine PC aa C32:3. |
|
Formal Description Interaction-ID: 49086 |
phenotype sex affects_quantity of drug/chemical compound PC aa C42:0 |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The concentrations of phosphatidylcholines tended to be significantly lower in males compared to females. The most significant difference between gender could be seen for the phosphatidylcholine PC aa C32:3. |
|
Formal Description Interaction-ID: 49087 |
phenotype sex affects_quantity of drug/chemical compound PC aa C36:3 |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The concentrations of phosphatidylcholines tended to be significantly lower in males compared to females. The most significant difference between gender could be seen for the phosphatidylcholine PC aa C32:3. |
|
Formal Description Interaction-ID: 49088 |
phenotype sex affects_quantity of drug/chemical compound PC aa C38:5 |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The concentrations of phosphatidylcholines tended to be significantly lower in males compared to females. The most significant difference between gender could be seen for the phosphatidylcholine PC aa C32:3. |
|
Formal Description Interaction-ID: 49089 |
phenotype sex affects_quantity of drug/chemical compound PC aa C42:1 |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The concentrations of phosphatidylcholines tended to be significantly lower in males compared to females. The most significant difference between gender could be seen for the phosphatidylcholine PC aa C32:3. |
|
Formal Description Interaction-ID: 49090 |
phenotype sex affects_quantity of drug/chemical compound PC aa C40:1 |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The concentrations of phosphatidylcholines tended to be significantly lower in males compared to females. The most significant difference between gender could be seen for the phosphatidylcholine PC aa C32:3. |
|
Formal Description Interaction-ID: 49091 |
phenotype sex affects_quantity of drug/chemical compound PC aa C40:6 |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The concentrations of phosphatidylcholines tended to be significantly lower in males compared to females. The most significant difference between gender could be seen for the phosphatidylcholine PC aa C32:3. |
|
Formal Description Interaction-ID: 49092 |
phenotype sex affects_quantity of drug/chemical compound PC aa C42:6 |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The concentrations of phosphatidylcholines tended to be significantly lower in males compared to females. The most significant difference between gender could be seen for the phosphatidylcholine PC aa C32:3. |
|
Formal Description Interaction-ID: 49093 |
phenotype sex affects_quantity of drug/chemical compound PC aa C34:2 |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The concentrations of phosphatidylcholines tended to be significantly lower in males compared to females. The most significant difference between gender could be seen for the phosphatidylcholine PC aa C32:3. |
|
Formal Description Interaction-ID: 49094 |
phenotype sex affects_quantity of drug/chemical compound PC aa C40:3 |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The concentrations of phosphatidylcholines tended to be significantly lower in males compared to females. The most significant difference between gender could be seen for the phosphatidylcholine PC aa C32:3. |
|
Formal Description Interaction-ID: 49095 |
phenotype sex affects_quantity of drug/chemical compound PC aa C32:1 |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The concentrations of phosphatidylcholines tended to be significantly lower in males compared to females. The most significant difference between gender could be seen for the phosphatidylcholine PC aa C32:3. |
|
Formal Description Interaction-ID: 49096 |
phenotype sex affects_quantity of drug/chemical compound PC aa C42:5 |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The concentrations of phosphatidylcholines tended to be significantly lower in males compared to females. The most significant difference between gender could be seen for the phosphatidylcholine PC aa C32:3. |
|
Formal Description Interaction-ID: 49097 |
phenotype sex affects_quantity of drug/chemical compound PC aa C38:6 |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The concentrations of phosphatidylcholines tended to be significantly lower in males compared to females. The most significant difference between gender could be seen for the phosphatidylcholine PC aa C32:3. |
|
Formal Description Interaction-ID: 49098 |
phenotype sex affects_quantity of drug/chemical compound PC aa C42:4 |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The concentrations of phosphatidylcholines tended to be significantly lower in males compared to females. The most significant difference between gender could be seen for the phosphatidylcholine PC aa C32:3. |
|
Formal Description Interaction-ID: 49099 |
phenotype sex affects_quantity of drug/chemical compound PC ae C30:2 |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The concentrations of phosphatidylcholines tended to be significantly lower in males compared to females. The most significant difference between gender could be seen for the phosphatidylcholine PC aa C32:3. |
|
Formal Description Interaction-ID: 49100 |
phenotype sex affects_quantity of drug/chemical compound PC ae C40:3 |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The concentrations of phosphatidylcholines tended to be significantly lower in males compared to females. The most significant difference between gender could be seen for the phosphatidylcholine PC aa C32:3. |
|
Formal Description Interaction-ID: 49101 |
phenotype sex affects_quantity of drug/chemical compound PC ae C38:3 |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The concentrations of phosphatidylcholines tended to be significantly lower in males compared to females. The most significant difference between gender could be seen for the phosphatidylcholine PC aa C32:3. |
|
Formal Description Interaction-ID: 49102 |
phenotype sex affects_quantity of drug/chemical compound PC ae C32:2 |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The concentrations of phosphatidylcholines tended to be significantly lower in males compared to females. The most significant difference between gender could be seen for the phosphatidylcholine PC aa C32:3. |
|
Formal Description Interaction-ID: 49103 |
phenotype sex affects_quantity of drug/chemical compound PC ae C36:1 |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The concentrations of phosphatidylcholines tended to be significantly lower in males compared to females. The most significant difference between gender could be seen for the phosphatidylcholine PC aa C32:3. |
|
Formal Description Interaction-ID: 49104 |
phenotype sex affects_quantity of drug/chemical compound PC ae C36:2 |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The concentrations of phosphatidylcholines tended to be significantly lower in males compared to females. The most significant difference between gender could be seen for the phosphatidylcholine PC aa C32:3. |
|
Formal Description Interaction-ID: 49105 |
phenotype sex affects_quantity of drug/chemical compound PC ae C34:1 |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The concentrations of phosphatidylcholines tended to be significantly lower in males compared to females. The most significant difference between gender could be seen for the phosphatidylcholine PC aa C32:3. |
|
Formal Description Interaction-ID: 49106 |
phenotype sex affects_quantity of drug/chemical compound PC ae C38:2 |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The concentrations of phosphatidylcholines tended to be significantly lower in males compared to females. The most significant difference between gender could be seen for the phosphatidylcholine PC aa C32:3. |
|
Formal Description Interaction-ID: 49107 |
phenotype sex affects_quantity of drug/chemical compound PC ae C34:2 |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The concentrations of phosphatidylcholines tended to be significantly lower in males compared to females. The most significant difference between gender could be seen for the phosphatidylcholine PC aa C32:3. |
|
Formal Description Interaction-ID: 49108 |
phenotype sex affects_quantity of drug/chemical compound PC ae C40:2 |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The concentrations of phosphatidylcholines tended to be significantly lower in males compared to females. The most significant difference between gender could be seen for the phosphatidylcholine PC aa C32:3. |
|
Formal Description Interaction-ID: 49109 |
phenotype sex affects_quantity of drug/chemical compound PC ae C30:0 |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The concentrations of phosphatidylcholines tended to be significantly lower in males compared to females. The most significant difference between gender could be seen for the phosphatidylcholine PC aa C32:3. |
|
Formal Description Interaction-ID: 49110 |
phenotype sex affects_quantity of drug/chemical compound PC ae C36:3 |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The concentrations of phosphatidylcholines tended to be significantly lower in males compared to females. The most significant difference between gender could be seen for the phosphatidylcholine PC aa C32:3. |
|
Formal Description Interaction-ID: 49111 |
phenotype sex affects_quantity of drug/chemical compound PC ae C34:0 |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The concentrations of phosphatidylcholines tended to be significantly lower in males compared to females. The most significant difference between gender could be seen for the phosphatidylcholine PC aa C32:3. |
|
Formal Description Interaction-ID: 49112 |
phenotype sex affects_quantity of drug/chemical compound PC ae C38:0 |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The concentrations of phosphatidylcholines tended to be significantly lower in males compared to females. The most significant difference between gender could be seen for the phosphatidylcholine PC aa C32:3. |
|
Formal Description Interaction-ID: 49113 |
phenotype sex affects_quantity of drug/chemical compound PC ae C38:6 |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The concentrations of phosphatidylcholines tended to be significantly lower in males compared to females. The most significant difference between gender could be seen for the phosphatidylcholine PC aa C32:3. |
|
Formal Description Interaction-ID: 49114 |
phenotype sex affects_quantity of drug/chemical compound PC ae C40:6 |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The concentrations of phosphatidylcholines tended to be significantly lower in males compared to females. The most significant difference between gender could be seen for the phosphatidylcholine PC aa C32:3. |
|
Formal Description Interaction-ID: 49115 |
phenotype sex affects_quantity of drug/chemical compound PC ae C34:3 |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The concentrations of phosphatidylcholines tended to be significantly lower in males compared to females. The most significant difference between gender could be seen for the phosphatidylcholine PC aa C32:3. |
|
Formal Description Interaction-ID: 49116 |
phenotype sex affects_quantity of drug/chemical compound PC ae C42:2 |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The concentrations of phosphatidylcholines tended to be significantly lower in males compared to females. The most significant difference between gender could be seen for the phosphatidylcholine PC aa C32:3. |
|
Formal Description Interaction-ID: 49117 |
phenotype sex affects_quantity of drug/chemical compound PC ae C32:1 |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The concentrations of phosphatidylcholines tended to be significantly lower in males compared to females. The most significant difference between gender could be seen for the phosphatidylcholine PC aa C32:3. |
|
Formal Description Interaction-ID: 49118 |
phenotype sex affects_quantity of drug/chemical compound PC ae C38:4 |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The concentrations of phosphatidylcholines tended to be significantly lower in males compared to females. The most significant difference between gender could be seen for the phosphatidylcholine PC aa C32:3. |
|
Formal Description Interaction-ID: 49119 |
phenotype sex affects_quantity of drug/chemical compound PC ae C42:3 |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The concentrations of phosphatidylcholines tended to be significantly lower in males compared to females. The most significant difference between gender could be seen for the phosphatidylcholine PC aa C32:3. |
|
Formal Description Interaction-ID: 49120 |
phenotype sex affects_quantity of drug/chemical compound PC ae C40:4 |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The concentrations of phosphatidylcholines tended to be significantly lower in males compared to females. The most significant difference between gender could be seen for the phosphatidylcholine PC aa C32:3. |
|
Formal Description Interaction-ID: 49121 |
phenotype sex affects_quantity of drug/chemical compound PC ae C40:5 |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The concentrations of phosphatidylcholines tended to be significantly lower in males compared to females. The most significant difference between gender could be seen for the phosphatidylcholine PC aa C32:3. |
|
Formal Description Interaction-ID: 49122 |
phenotype sex affects_quantity of drug/chemical compound PC ae C40:0 |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The concentrations of phosphatidylcholines tended to be significantly lower in males compared to females. The most significant difference between gender could be seen for the phosphatidylcholine PC aa C32:3. |
|
Formal Description Interaction-ID: 49123 |
phenotype sex affects_quantity of drug/chemical compound PC ae C44:4 |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The concentrations of phosphatidylcholines tended to be significantly lower in males compared to females. The most significant difference between gender could be seen for the phosphatidylcholine PC aa C32:3. |
|
Formal Description Interaction-ID: 49124 |
phenotype sex affects_quantity of drug/chemical compound PC ae C44:3 |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The concentrations of phosphatidylcholines tended to be significantly lower in males compared to females. The most significant difference between gender could be seen for the phosphatidylcholine PC aa C32:3. |
|
Formal Description Interaction-ID: 49125 |
phenotype sex affects_quantity of drug/chemical compound PC ae C42:4 |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The concentrations of phosphatidylcholines tended to be significantly lower in males compared to females. The most significant difference between gender could be seen for the phosphatidylcholine PC aa C32:3. |
|
Formal Description Interaction-ID: 49126 |
phenotype sex affects_quantity of drug/chemical compound PC ae C42:5 |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The concentrations of phosphatidylcholines tended to be significantly lower in males compared to females. The most significant difference between gender could be seen for the phosphatidylcholine PC aa C32:3. |
|
Formal Description Interaction-ID: 49127 |
phenotype sex affects_quantity of drug/chemical compound PC ae C38:1 |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The concentrations of phosphatidylcholines tended to be significantly lower in males compared to females. The most significant difference between gender could be seen for the phosphatidylcholine PC aa C32:3. |
|
Formal Description Interaction-ID: 49128 |
phenotype sex affects_quantity of drug/chemical compound PC ae C44:6 |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The concentrations of phosphatidylcholines tended to be significantly lower in males compared to females. The most significant difference between gender could be seen for the phosphatidylcholine PC aa C32:3. |
|
Formal Description Interaction-ID: 49129 |
phenotype sex affects_quantity of drug/chemical compound PC ae C44:5 |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The concentrations of phosphatidylcholines tended to be significantly lower in males compared to females. The most significant difference between gender could be seen for the phosphatidylcholine PC aa C32:3. |
|
Formal Description Interaction-ID: 49130 |
phenotype sex affects_quantity of drug/chemical compound PC ae C42:0 |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. Lysophosphatidylcholine (lysoPC a Cx:y) concentrations were higher in males compared to females. |
|
Formal Description Interaction-ID: 49131 |
phenotype sex affects_quantity of drug/chemical compound LysoPC(18:2) |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. Lysophosphatidylcholine (lysoPC a Cx:y) concentrations were higher in males compared to females. |
|
Formal Description Interaction-ID: 49132 |
phenotype sex affects_quantity of drug/chemical compound LysoPC(20:4) |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. Lysophosphatidylcholine (lysoPC a Cx:y) concentrations were higher in males compared to females. |
|
Formal Description Interaction-ID: 49133 |
phenotype sex affects_quantity of drug/chemical compound LysoPC(18:1) |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. Lysophosphatidylcholine (lysoPC a Cx:y) concentrations were higher in males compared to females. |
|
Formal Description Interaction-ID: 49134 |
phenotype sex affects_quantity of drug/chemical compound LysoPC(16:0) |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. Lysophosphatidylcholine (lysoPC a Cx:y) concentrations were higher in males compared to females. |
|
Formal Description Interaction-ID: 49135 |
phenotype sex affects_quantity of drug/chemical compound LysoPC(20:3) |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. Lysophosphatidylcholine (lysoPC a Cx:y) concentrations were higher in males compared to females. |
|
Formal Description Interaction-ID: 49136 |
phenotype sex affects_quantity of drug/chemical compound LysoPC(18:0) |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The concentrations of most sphingomyelins were significantly lower in men than in women. |
|
Formal Description Interaction-ID: 49137 |
phenotype sex affects_quantity of drug/chemical compound SM C16:1 |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The concentrations of most sphingomyelins were significantly lower in men than in women. |
|
Formal Description Interaction-ID: 49139 |
phenotype sex affects_quantity of drug/chemical compound SM C18:1 |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The concentrations of most sphingomyelins were significantly lower in men than in women. |
|
Formal Description Interaction-ID: 49140 |
phenotype sex affects_quantity of drug/chemical compound SM C20:2 |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The concentrations of most sphingomyelins were significantly lower in men than in women. |
|
Formal Description Interaction-ID: 49141 |
phenotype sex affects_quantity of drug/chemical compound SM (OH) C22:2 |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The concentrations of most sphingomyelins were significantly lower in men than in women. |
|
Formal Description Interaction-ID: 49142 |
phenotype sex affects_quantity of drug/chemical compound SM (OH) C14:1 |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The concentrations of most sphingomyelins were significantly lower in men than in women. |
|
Formal Description Interaction-ID: 49143 |
phenotype sex affects_quantity of drug/chemical compound SM (OH) C16:1 |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The concentrations of most sphingomyelins were significantly lower in men than in women. |
|
Formal Description Interaction-ID: 49144 |
phenotype sex affects_quantity of drug/chemical compound SM (OH) C22:1 |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The concentrations of most sphingomyelins were significantly lower in men than in women. |
|
Formal Description Interaction-ID: 49145 |
phenotype sex affects_quantity of drug/chemical compound SM C18:0 |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The concentrations of most sphingomyelins were significantly lower in men than in women. |
|
Formal Description Interaction-ID: 49146 |
phenotype sex affects_quantity of drug/chemical compound SM C16:0 |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The concentrations of most sphingomyelins were significantly lower in men than in women. |
|
Formal Description Interaction-ID: 49147 |
phenotype sex affects_quantity of drug/chemical compound SM (OH) C24:1 |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The concentrations of most sphingomyelins were significantly lower in men than in women. |
|
Formal Description Interaction-ID: 49148 |
phenotype sex affects_quantity of drug/chemical compound SM C24:1 |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The concentration of H1 which is the sum of C6-sugars, was significantly higher in males compared to females. |
|
Formal Description Interaction-ID: 49149 |
phenotype sex affects_quantity of drug/chemical compound |
| Comment | All phenotypic analysis steps were performed on population-based cohort data from KORA F4 (1452 males, 1552 females) and KORA F3 (197 males, 180 females) with fasting serum concentrations of 131 metabolites. A combined meta-analysis of KORA F4 and KORA F3 revealed 113 metabolites with a significant effect of sex. The concentrations of phosphatidylcholines tended to be significantly lower in males compared to females. The most significant difference between gender could be seen for the phosphatidylcholine PC aa C32:3. |
|
Formal Description Interaction-ID: 49153 |
phenotype sex affects_quantity of drug/chemical compound PC aa C34:3 |
| Comment | Eight SNPs on chromosome 2 showed genome-wide significant differences in SNP effects (beta-estimates) between men and women for association with glycine. The absolute beta-estimates of all eight significant SNPs were higher in women compared to men. The strongest gender difference was seen at SNP rs715. For men the observed effect of rs715 was -0.067 and for women -0.2. SNP rs715 is part of the 3' UTR region of the CPS1 gene. SNP rs7422339 is in a non-synonymous coding region of CPS1. All other significant SNPs are intergenetic but located in the same region. The gender-specific effect of SNP rs7422339 was significantly replicated as the difference between the beta-estimates of men and women was of the same direction in the discovery sample and in the replication cohort Rep-KORA F4 and the p-value of the test of differences was lower than the replication significance niveau. The other SNPs of the CPS1 gene region also showed significant gender-specific effects but these effects could not be replicated in the Rep-KORA F3 cohort. As the effect-sizes and differences for the SNP rs7422339 are similar and at least for the other SNPs are pointing into the same direction as in the discovery set, the failed replication in Rep-KORA F3 might be a problem of power due to the smaller sample size. |
|
Formal Description Interaction-ID: 49157 |
|
| Comment | Eight SNPs on chromosome 2 showed genome-wide significant differences in SNP effects (beta-estimates) between men and women for association with glycine. The absolute beta-estimates of all eight significant SNPs were higher in women compared to men. The strongest gender difference was seen at SNP rs715. For men the observed effect of rs715 was -0.067 and for women -0.2. SNP rs715 is part of the 3' UTR region of the CPS1 gene. SNP rs7422339 is in a non-synonymous coding region of CPS1. All other significant SNPs are intergenetic but located in the same region. The gender-specific effect of SNP rs7422339 was significantly replicated as the difference between the beta-estimates of men and women was of the same direction in the discovery sample and in the replication cohort Rep-KORA F4 and the p-value of the test of differences was lower than the replication significance niveau. The other SNPs of the CPS1 gene region also showed significant gender-specific effects but these effects could not be replicated in the Rep-KORA F3 cohort. As the effect-sizes and differences for the SNP rs7422339 are similar and at least for the other SNPs are pointing into the same direction as in the discovery set, the failed replication in Rep-KORA F3 might be a problem of power due to the smaller sample size. |
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Formal Description Interaction-ID: 49161 |
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| Comment | Eight SNPs on chromosome 2 showed genome-wide significant differences in SNP effects (beta-estimates) between men and women for association with glycine. The absolute beta-estimates of all eight significant SNPs were higher in women compared to men. The strongest gender difference was seen at SNP rs715. For men the observed effect of rs715 was -0.067 and for women -0.2. SNP rs715 is part of the 3' UTR region of the CPS1 gene. SNP rs7422339 is in a non-synonymous coding region of CPS1. All other significant SNPs are intergenetic but located in the same region. The gender-specific effect of SNP rs7422339 was significantly replicated as the difference between the beta-estimates of men and women was of the same direction in the discovery sample and in the replication cohort Rep-KORA F4 and the p-value of the test of differences was lower than the replication significance niveau. The other SNPs of the CPS1 gene region also showed significant gender-specific effects but these effects could not be replicated in the Rep-KORA F3 cohort. As the effect-sizes and differences for the SNP rs7422339 are similar and at least for the other SNPs are pointing into the same direction as in the discovery set, the failed replication in Rep-KORA F3 might be a problem of power due to the smaller sample size. |
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Formal Description Interaction-ID: 49162 |
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| Comment | Eight SNPs on chromosome 2 showed genome-wide significant differences in SNP effects (beta-estimates) between men and women for association with glycine. The absolute beta-estimates of all eight significant SNPs were higher in women compared to men. The strongest gender difference was seen at SNP rs715. For men the observed effect of rs715 was -0.067 and for women -0.2. SNP rs715 is part of the 3' UTR region of the CPS1 gene. SNP rs7422339 is in a non-synonymous coding region of CPS1. All other significant SNPs are intergenetic but located in the same region. The gender-specific effect of SNP rs7422339 was significantly replicated as the difference between the beta-estimates of men and women was of the same direction in the discovery sample and in the replication cohort Rep-KORA F4 and the p-value of the test of differences was lower than the replication significance niveau. The other SNPs of the CPS1 gene region also showed significant gender-specific effects but these effects could not be replicated in the Rep-KORA F3 cohort. As the effect-sizes and differences for the SNP rs7422339 are similar and at least for the other SNPs are pointing into the same direction as in the discovery set, the failed replication in Rep-KORA F3 might be a problem of power due to the smaller sample size. |
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Formal Description Interaction-ID: 49163 |
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| Comment | Eight SNPs on chromosome 2 showed genome-wide significant differences in SNP effects (beta-estimates) between men and women for association with glycine. The absolute beta-estimates of all eight significant SNPs were higher in women compared to men. The strongest gender difference was seen at SNP rs715. For men the observed effect of rs715 was -0.067 and for women -0.2. SNP rs715 is part of the 3' UTR region of the CPS1 gene. SNP rs7422339 is in a non-synonymous coding region of CPS1. All other significant SNPs are intergenetic but located in the same region. The gender-specific effect of SNP rs7422339 was significantly replicated as the difference between the beta-estimates of men and women was of the same direction in the discovery sample and in the replication cohort Rep-KORA F4 and the p-value of the test of differences was lower than the replication significance niveau. The other SNPs of the CPS1 gene region also showed significant gender-specific effects but these effects could not be replicated in the Rep-KORA F3 cohort. As the effect-sizes and differences for the SNP rs7422339 are similar and at least for the other SNPs are pointing into the same direction as in the discovery set, the failed replication in Rep-KORA F3 might be a problem of power due to the smaller sample size. |
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Formal Description Interaction-ID: 49164 |
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| Comment | Eight SNPs on chromosome 2 showed genome-wide significant differences in SNP effects (beta-estimates) between men and women for association with glycine. The absolute beta-estimates of all eight significant SNPs were higher in women compared to men. The strongest gender difference was seen at SNP rs715. For men the observed effect of rs715 was -0.067 and for women -0.2. SNP rs715 is part of the 3' UTR region of the CPS1 gene. SNP rs7422339 is in a non-synonymous coding region of CPS1. All other significant SNPs are intergenetic but located in the same region. The gender-specific effect of SNP rs7422339 was significantly replicated as the difference between the beta-estimates of men and women was of the same direction in the discovery sample and in the replication cohort Rep-KORA F4 and the p-value of the test of differences was lower than the replication significance niveau. The other SNPs of the CPS1 gene region also showed significant gender-specific effects but these effects could not be replicated in the Rep-KORA F3 cohort. As the effect-sizes and differences for the SNP rs7422339 are similar and at least for the other SNPs are pointing into the same direction as in the discovery set, the failed replication in Rep-KORA F3 might be a problem of power due to the smaller sample size. |
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Formal Description Interaction-ID: 49165 |
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| Comment | Eight SNPs on chromosome 2 showed genome-wide significant differences in SNP effects (beta-estimates) between men and women for association with glycine. The absolute beta-estimates of all eight significant SNPs were higher in women compared to men. The strongest gender difference was seen at SNP rs715. For men the observed effect of rs715 was -0.067 and for women -0.2. SNP rs715 is part of the 3' UTR region of the CPS1 gene. SNP rs7422339 is in a non-synonymous coding region of CPS1. All other significant SNPs are intergenetic but located in the same region. The gender-specific effect of SNP rs7422339 was significantly replicated as the difference between the beta-estimates of men and women was of the same direction in the discovery sample and in the replication cohort Rep-KORA F4 and the p-value of the test of differences was lower than the replication significance niveau. The other SNPs of the CPS1 gene region also showed significant gender-specific effects but these effects could not be replicated in the Rep-KORA F3 cohort. As the effect-sizes and differences for the SNP rs7422339 are similar and at least for the other SNPs are pointing into the same direction as in the discovery set, the failed replication in Rep-KORA F3 might be a problem of power due to the smaller sample size. |
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Formal Description Interaction-ID: 49166 |
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| Comment | Eight SNPs on chromosome 2 showed genome-wide significant differences in SNP effects (beta-estimates) between men and women for association with glycine. The absolute beta-estimates of all eight significant SNPs were higher in women compared to men. The strongest gender difference was seen at SNP rs715. For men the observed effect of rs715 was -0.067 and for women -0.2. SNP rs715 is part of the 3' UTR region of the CPS1 gene. SNP rs7422339 is in a non-synonymous coding region of CPS1. All other significant SNPs are intergenetic but located in the same region. The gender-specific effect of SNP rs7422339 was significantly replicated as the difference between the beta-estimates of men and women was of the same direction in the discovery sample and in the replication cohort Rep-KORA F4 and the p-value of the test of differences was lower than the replication significance niveau. The other SNPs of the CPS1 gene region also showed significant gender-specific effects but these effects could not be replicated in the Rep-KORA F3 cohort. As the effect-sizes and differences for the SNP rs7422339 are similar and at least for the other SNPs are pointing into the same direction as in the discovery set, the failed replication in Rep-KORA F3 might be a problem of power due to the smaller sample size. |
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Formal Description Interaction-ID: 49167 |
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| Comment | Eight SNPs on chromosome 2 showed genome-wide significant differences in SNP effects (beta-estimates) between men and women for association with glycine. The absolute beta-estimates of all eight significant SNPs were higher in women compared to men. The strongest gender difference was seen at SNP rs715. For men the observed effect of rs715 was -0.067 and for women -0.2. SNP rs715 is part of the 3' UTR region of the CPS1 gene. SNP rs7422339 is in a non-synonymous coding region of CPS1. All other significant SNPs are intergenetic but located in the same region. The gender-specific effect of SNP rs7422339 was significantly replicated as the difference between the beta-estimates of men and women was of the same direction in the discovery sample and in the replication cohort Rep-KORA F4 and the p-value of the test of differences was lower than the replication significance niveau. The other SNPs of the CPS1 gene region also showed significant gender-specific effects but these effects could not be replicated in the Rep-KORA F3 cohort. As the effect-sizes and differences for the SNP rs7422339 are similar and at least for the other SNPs are pointing into the same direction as in the discovery set, the failed replication in Rep-KORA F3 might be a problem of power due to the smaller sample size. |
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Formal Description Interaction-ID: 49168 |
SNP affects_quantity of drug/chemical compound |
| Drugbank entries | Show/Hide entries for |
| Comment | Eight SNPs on chromosome 2 showed genome-wide significant differences in SNP effects (beta-estimates) between men and women for association with glycine. The absolute beta-estimates of all eight significant SNPs were higher in women compared to men. The strongest gender difference was seen at SNP rs715. For men the observed effect of rs715 was -0.067 and for women -0.2. SNP rs715 is part of the 3' UTR region of the CPS1 gene. SNP rs7422339 is in a non-synonymous coding region of CPS1. All other significant SNPs are intergenetic but located in the same region. The gender-specific effect of SNP rs7422339 was significantly replicated as the difference between the beta-estimates of men and women was of the same direction in the discovery sample and in the replication cohort Rep-KORA F4 and the p-value of the test of differences was lower than the replication significance niveau. The other SNPs of the CPS1 gene region also showed significant gender-specific effects but these effects could not be replicated in the Rep-KORA F3 cohort. As the effect-sizes and differences for the SNP rs7422339 are similar and at least for the other SNPs are pointing into the same direction as in the discovery set, the failed replication in Rep-KORA F3 might be a problem of power due to the smaller sample size. |
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Formal Description Interaction-ID: 49169 |
SNP affects_quantity of drug/chemical compound |
| Drugbank entries | Show/Hide entries for |
| Comment | Eight SNPs on chromosome 2 showed genome-wide significant differences in SNP effects (beta-estimates) between men and women for association with glycine. The absolute beta-estimates of all eight significant SNPs were higher in women compared to men. The strongest gender difference was seen at SNP rs715. For men the observed effect of rs715 was -0.067 and for women -0.2. SNP rs715 is part of the 3' UTR region of the CPS1 gene. SNP rs7422339 is in a non-synonymous coding region of CPS1. All other significant SNPs are intergenetic but located in the same region. The gender-specific effect of SNP rs7422339 was significantly replicated as the difference between the beta-estimates of men and women was of the same direction in the discovery sample and in the replication cohort Rep-KORA F4 and the p-value of the test of differences was lower than the replication significance niveau. The other SNPs of the CPS1 gene region also showed significant gender-specific effects but these effects could not be replicated in the Rep-KORA F3 cohort. As the effect-sizes and differences for the SNP rs7422339 are similar and at least for the other SNPs are pointing into the same direction as in the discovery set, the failed replication in Rep-KORA F3 might be a problem of power due to the smaller sample size. |
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Formal Description Interaction-ID: 49170 |
SNP affects_quantity of drug/chemical compound |
| Drugbank entries | Show/Hide entries for |
| Comment | Eight SNPs on chromosome 2 showed genome-wide significant differences in SNP effects (beta-estimates) between men and women for association with glycine. The absolute beta-estimates of all eight significant SNPs were higher in women compared to men. The strongest gender difference was seen at SNP rs715. For men the observed effect of rs715 was -0.067 and for women -0.2. SNP rs715 is part of the 3' UTR region of the CPS1 gene. SNP rs7422339 is in a non-synonymous coding region of CPS1. All other significant SNPs are intergenetic but located in the same region. The gender-specific effect of SNP rs7422339 was significantly replicated as the difference between the beta-estimates of men and women was of the same direction in the discovery sample and in the replication cohort Rep-KORA F4 and the p-value of the test of differences was lower than the replication significance niveau. The other SNPs of the CPS1 gene region also showed significant gender-specific effects but these effects could not be replicated in the Rep-KORA F3 cohort. As the effect-sizes and differences for the SNP rs7422339 are similar and at least for the other SNPs are pointing into the same direction as in the discovery set, the failed replication in Rep-KORA F3 might be a problem of power due to the smaller sample size. |
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Formal Description Interaction-ID: 49171 |
SNP affects_quantity of drug/chemical compound |
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| Comment | Eight SNPs on chromosome 2 showed genome-wide significant differences in SNP effects (beta-estimates) between men and women for association with glycine. The absolute beta-estimates of all eight significant SNPs were higher in women compared to men. The strongest gender difference was seen at SNP rs715. For men the observed effect of rs715 was -0.067 and for women -0.2. SNP rs715 is part of the 3' UTR region of the CPS1 gene. SNP rs7422339 is in a non-synonymous coding region of CPS1. All other significant SNPs are intergenetic but located in the same region. The gender-specific effect of SNP rs7422339 was significantly replicated as the difference between the beta-estimates of men and women was of the same direction in the discovery sample and in the replication cohort Rep-KORA F4 and the p-value of the test of differences was lower than the replication significance niveau. The other SNPs of the CPS1 gene region also showed significant gender-specific effects but these effects could not be replicated in the Rep-KORA F3 cohort. As the effect-sizes and differences for the SNP rs7422339 are similar and at least for the other SNPs are pointing into the same direction as in the discovery set, the failed replication in Rep-KORA F3 might be a problem of power due to the smaller sample size. |
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Formal Description Interaction-ID: 49172 |
SNP affects_quantity of drug/chemical compound |
| Drugbank entries | Show/Hide entries for |
| Comment | Eight SNPs on chromosome 2 showed genome-wide significant differences in SNP effects (beta-estimates) between men and women for association with glycine. The absolute beta-estimates of all eight significant SNPs were higher in women compared to men. The strongest gender difference was seen at SNP rs715. For men the observed effect of rs715 was -0.067 and for women -0.2. SNP rs715 is part of the 3' UTR region of the CPS1 gene. SNP rs7422339 is in a non-synonymous coding region of CPS1. All other significant SNPs are intergenetic but located in the same region. The gender-specific effect of SNP rs7422339 was significantly replicated as the difference between the beta-estimates of men and women was of the same direction in the discovery sample and in the replication cohort Rep-KORA F4 and the p-value of the test of differences was lower than the replication significance niveau. The other SNPs of the CPS1 gene region also showed significant gender-specific effects but these effects could not be replicated in the Rep-KORA F3 cohort. As the effect-sizes and differences for the SNP rs7422339 are similar and at least for the other SNPs are pointing into the same direction as in the discovery set, the failed replication in Rep-KORA F3 might be a problem of power due to the smaller sample size. |
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Formal Description Interaction-ID: 49173 |
SNP affects_quantity of drug/chemical compound |
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| Comment | Eight SNPs on chromosome 2 showed genome-wide significant differences in SNP effects (beta-estimates) between men and women for association with glycine. The absolute beta-estimates of all eight significant SNPs were higher in women compared to men. The strongest gender difference was seen at SNP rs715. For men the observed effect of rs715 was -0.067 and for women -0.2. SNP rs715 is part of the 3' UTR region of the CPS1 gene. SNP rs7422339 is in a non-synonymous coding region of CPS1. All other significant SNPs are intergenetic but located in the same region. The gender-specific effect of SNP rs7422339 was significantly replicated as the difference between the beta-estimates of men and women was of the same direction in the discovery sample and in the replication cohort Rep-KORA F4 and the p-value of the test of differences was lower than the replication significance niveau. The other SNPs of the CPS1 gene region also showed significant gender-specific effects but these effects could not be replicated in the Rep-KORA F3 cohort. As the effect-sizes and differences for the SNP rs7422339 are similar and at least for the other SNPs are pointing into the same direction as in the discovery set, the failed replication in Rep-KORA F3 might be a problem of power due to the smaller sample size. |
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Formal Description Interaction-ID: 49174 |
SNP affects_quantity of drug/chemical compound |
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| Comment | Eight SNPs on chromosome 2 showed genome-wide significant differences in SNP effects (beta-estimates) between men and women for association with glycine. The absolute beta-estimates of all eight significant SNPs were higher in women compared to men. The strongest gender difference was seen at SNP rs715. For men the observed effect of rs715 was -0.067 and for women -0.2. SNP rs715 is part of the 3' UTR region of the CPS1 gene. SNP rs7422339 is in a non-synonymous coding region of CPS1. All other significant SNPs are intergenetic but located in the same region. The gender-specific effect of SNP rs7422339 was significantly replicated as the difference between the beta-estimates of men and women was of the same direction in the discovery sample and in the replication cohort Rep-KORA F4 and the p-value of the test of differences was lower than the replication significance niveau. The other SNPs of the CPS1 gene region also showed significant gender-specific effects but these effects could not be replicated in the Rep-KORA F3 cohort. As the effect-sizes and differences for the SNP rs7422339 are similar and at least for the other SNPs are pointing into the same direction as in the discovery set, the failed replication in Rep-KORA F3 might be a problem of power due to the smaller sample size. |
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Formal Description Interaction-ID: 49175 |
SNP affects_quantity of drug/chemical compound |
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