General Information:

Id: 488 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Rattus norvegicus
male
article
Reference: Ye JM et al.(2002) Prior thiazolidinedione treatment preserves insulin sensitivity in normal rats during acute fatty acid elevation: role of the liver. Endocrinology 143: 4527-4535 [PMID: 12446579]

Interaction Information:

Comment Pioglitazone-induced muscle insulin sensitization was largely diminished after matching plasma free fatty acid (FFA) elevation, but insulin-stimulated protein kinase B phosphorylation was protected.
Formal Description
Interaction-ID: 2302

drug/chemical compound

Pioglitazone

affects_phosphorylation of

gene/protein

AKT1

in muscle
Drugbank entries Show/Hide entries for Pioglitazone or AKT1