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Field	Query

	Field	Term

General Information:

Id:	482
Diseases:	Parkinson disease
Organism:	Homo sapiens
Tissue/Cell line:	BTO:0000793 SH-SY5Y cell
Publication type:	article
Reference:	Gomez-Santos C et al.(2003) Dopamine induces autophagic cell death and alpha-synuclein increase in human neuroblastoma SH-SY5Y cells. J. Neurosci. Res. 73: 341-350 [PMID: 12868068]

Interaction Information:

Comment	Dopamine reduced cell viability in a dose-dependent way. This effect was almost completely prevented by antioxidants such as ascorbic acid and N-acetylcysteine.
Formal Description Interaction-ID: 2271	drug/chemical compound Dopamine increases_activity of process neuron death
Drugbank entries	Show/Hide entries for Dopamine
Drugbank DB00988	Dopamine agonist DRD1
Drugbank DB00988	Dopamine ligand DBH
Drugbank DB00988	Dopamine agonist DRD5
Drugbank DB00988	Dopamine agonist DRD2
Drugbank DB00988	Dopamine agonist DRD3
Drugbank DB00988	Dopamine agonist DRD4
Drugbank DB00988	Dopamine inducer SLC6A3

Comment	Dopamine reduced cell viability in a dose-dependent way. This effect was almost completely prevented by antioxidants such as ascorbic acid and N-acetylcysteine.
Formal Description Interaction-ID: 2272	drug/chemical compound Ascorbate decreases_activity of process neuron death

Comment	Dopamine reduced cell viability in a dose-dependent way. This effect was almost completely prevented by antioxidants such as ascorbic acid and N-acetylcysteine.
Formal Description Interaction-ID: 2273	drug/chemical compound Acetylcysteine decreases_activity of process neuron death
Drugbank entries	Show/Hide entries for Acetylcysteine
Drugbank DB06151	Acetylcysteine reducer

Comment	Dopamine activates the stress-response kinase p38 in a dose-dependent way, but does not aktivate MEK1/2.
Formal Description Interaction-ID: 2274	drug/chemical compound Dopamine increases_activity of gene/protein p38 MAPK
Drugbank entries	Show/Hide entries for Dopamine
Drugbank DB00988	Dopamine agonist DRD1
Drugbank DB00988	Dopamine ligand DBH
Drugbank DB00988	Dopamine agonist DRD5
Drugbank DB00988	Dopamine agonist DRD2
Drugbank DB00988	Dopamine agonist DRD3
Drugbank DB00988	Dopamine agonist DRD4
Drugbank DB00988	Dopamine inducer SLC6A3

Comment	Dopamine activates the stress-response kinase p38 in a dose-dependent way, but does not aktivate MEK1/2.
Formal Description Interaction-ID: 2282	drug/chemical compound Dopamine increases_phosphorylation of gene/protein p38 MAPK
Drugbank entries	Show/Hide entries for Dopamine
Drugbank DB00988	Dopamine agonist DRD1
Drugbank DB00988	Dopamine ligand DBH
Drugbank DB00988	Dopamine agonist DRD5
Drugbank DB00988	Dopamine agonist DRD2
Drugbank DB00988	Dopamine agonist DRD3
Drugbank DB00988	Dopamine agonist DRD4
Drugbank DB00988	Dopamine inducer SLC6A3

Comment	Dopamine activates the stress-response kinase p38 in a dose-dependent way, but does not aktivate MEK1/2.
Formal Description Interaction-ID: 2284	drug/chemical compound Dopamine NOT increases_activity of gene/protein MAP2K1
Drugbank entries	Show/Hide entries for Dopamine or MAP2K1
Drugbank DB00988	Dopamine agonist DRD1
Drugbank DB00988	Dopamine ligand DBH
Drugbank DB00988	Dopamine agonist DRD5
Drugbank DB00988	Dopamine agonist DRD2
Drugbank DB00988	Dopamine agonist DRD3
Drugbank DB00988	Dopamine agonist DRD4
Drugbank DB00988	Dopamine inducer SLC6A3
Drugbank DB02152	K-252a not specified MAP2K1
Drugbank DB03115	5-Bromo-N-(2,3-Dihydroxypropoxy)-3,4-Dif ... not specified MAP2K1
Drugbank DB06892	(5S)-4,5-difluoro-6-[(2-fluoro-4-iodophe ... not specified MAP2K1
Drugbank DB07046	2-[(2-chloro-4-iodophenyl)amino]-N-{[(2R ... not specified MAP2K1
Drugbank DB07101	N-{[(2R)-2,3-dihydroxypropyl]oxy}-3,4-di ... not specified MAP2K1
Drugbank DB08130	N-(5-{3,4-difluoro-2-[(2-fluoro-4-iodoph ... not specified MAP2K1
Drugbank DB08208	2-[(4-ETHYNYL-2-FLUOROPHENYL)AMINO]-3,4- ... not specified MAP2K1
Drugbank DB03115	5-Bromo-N-(2,3-Dihydroxypropoxy)-3,4-Dif ... not specified MAP2K1

Comment	Dopamine activates the stress-response kinase p38 in a dose-dependent way, but does not aktivate MEK1/2.
Formal Description Interaction-ID: 2285	drug/chemical compound Dopamine NOT increases_phosphorylation of gene/protein MAP2K1
Drugbank entries	Show/Hide entries for Dopamine or MAP2K1
Drugbank DB00988	Dopamine agonist DRD1
Drugbank DB00988	Dopamine ligand DBH
Drugbank DB00988	Dopamine agonist DRD5
Drugbank DB00988	Dopamine agonist DRD2
Drugbank DB00988	Dopamine agonist DRD3
Drugbank DB00988	Dopamine agonist DRD4
Drugbank DB00988	Dopamine inducer SLC6A3
Drugbank DB02152	K-252a not specified MAP2K1
Drugbank DB03115	5-Bromo-N-(2,3-Dihydroxypropoxy)-3,4-Dif ... not specified MAP2K1
Drugbank DB06892	(5S)-4,5-difluoro-6-[(2-fluoro-4-iodophe ... not specified MAP2K1
Drugbank DB07046	2-[(2-chloro-4-iodophenyl)amino]-N-{[(2R ... not specified MAP2K1
Drugbank DB07101	N-{[(2R)-2,3-dihydroxypropyl]oxy}-3,4-di ... not specified MAP2K1
Drugbank DB08130	N-(5-{3,4-difluoro-2-[(2-fluoro-4-iodoph ... not specified MAP2K1
Drugbank DB08208	2-[(4-ETHYNYL-2-FLUOROPHENYL)AMINO]-3,4- ... not specified MAP2K1
Drugbank DB03115	5-Bromo-N-(2,3-Dihydroxypropoxy)-3,4-Dif ... not specified MAP2K1

Comment	Dopamine activates the stress-response kinase p38 in a dose-dependent way, but does not aktivate MEK1/2.
Formal Description Interaction-ID: 2286	drug/chemical compound Dopamine NOT increases_activity of gene/protein MAP2K2
Drugbank entries	Show/Hide entries for Dopamine
Drugbank DB00988	Dopamine agonist DRD1
Drugbank DB00988	Dopamine ligand DBH
Drugbank DB00988	Dopamine agonist DRD5
Drugbank DB00988	Dopamine agonist DRD2
Drugbank DB00988	Dopamine agonist DRD3
Drugbank DB00988	Dopamine agonist DRD4
Drugbank DB00988	Dopamine inducer SLC6A3

Comment	Dopamine activates the stress-response kinase p38 in a dose-dependent way, but does not aktivate MEK1/2.
Formal Description Interaction-ID: 2287	drug/chemical compound Dopamine NOT increases_phosphorylation of gene/protein MAP2K2
Drugbank entries	Show/Hide entries for Dopamine
Drugbank DB00988	Dopamine agonist DRD1
Drugbank DB00988	Dopamine ligand DBH
Drugbank DB00988	Dopamine agonist DRD5
Drugbank DB00988	Dopamine agonist DRD2
Drugbank DB00988	Dopamine agonist DRD3
Drugbank DB00988	Dopamine agonist DRD4
Drugbank DB00988	Dopamine inducer SLC6A3

Comment	Twenty-four hours after dopamine addition, the expression of alpha-synuclein was significntly increased.
Formal Description Interaction-ID: 2288	drug/chemical compound Dopamine increases_expression of gene/protein SNCA
Drugbank entries	Show/Hide entries for Dopamine
Drugbank DB00988	Dopamine agonist DRD1
Drugbank DB00988	Dopamine ligand DBH
Drugbank DB00988	Dopamine agonist DRD5
Drugbank DB00988	Dopamine agonist DRD2
Drugbank DB00988	Dopamine agonist DRD3
Drugbank DB00988	Dopamine agonist DRD4
Drugbank DB00988	Dopamine inducer SLC6A3

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