General Information:

Id: 4,769 (click here to show other Interactions for entry)
Diseases: Cardiovascular disease
Canis lupus familiaris
hypoperfused canine hearts
article/cited
Reference: Fujita M et al.(2004) Selective blockade of serotonin 5-HT2A receptor increases coronary blood flow via augmented cardiac nitric oxide release through 5-HT1B receptor in hypoperfused canine hearts J. Mol. Cell. Cardiol. 37: 1219-1223 [PMID: 15572052]

Interaction Information:

Comment Serotonin (5-HT) induces vasoconstriction via 5-HT2A receptors in smooth muscle cells and vasodilation through activating nitric oxide synthase eNOS via 5-HT1B receptors in endothelial cells. (cited information)
Formal Description
Interaction-ID: 47209

drug/chemical compound

Serotonin

increases_activity of

gene/protein

NOS3

in endothelial cells
Drugbank entries Show/Hide entries for NOS3