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General Information:

Id:	4,768
Diseases:	Cardiovascular disease Metabolic
Organism:	Rattus norvegicus
Publication type:	article
Reference:	Liu H et al.(2013) Acute tryptophan depletion reduces nitric oxide synthase in the rat hippocampus Neurochem. Res. 38: 2595-2603 [PMID: 24170240]

Interaction Information:

Comment	Acute tryptophan-depletion reduces nNOS activity as well as protein level. iNOS activity was not affected.
Formal Description Interaction-ID: 47199	drug/chemical compound Tryptophan increases_activity of gene/protein NOS1 in hippocampus
Drugbank entries	Show/Hide entries for NOS1
Drugbank DB00155	L-Citrulline not specified NOS1
Drugbank DB01821	L-N(Omega)-Nitroarginine-2,4-L-Diaminobu ... not specified NOS1
Drugbank DB01942	Formic Acid not specified NOS1
Drugbank DB01997	3-Bromo-7-Nitroindazole not specified NOS1
Drugbank DB02027	N-{(4s)-4-Amino-5-[(2-Aminoethyl)Amino]P ... not specified NOS1
Drugbank DB02044	N-(3-(Aminomethyl)Benzyl)Acetamidine not specified NOS1
Drugbank DB02077	L-N(Omega)-Nitroarginine-(4r)-Amino-L-Pr ... not specified NOS1
Drugbank DB02143	N-Isopropyl-N'-Hydroxyguanidine not specified NOS1
Drugbank DB02644	N-Omega-Propyl-L-Arginine not specified NOS1
Drugbank DB02692	(6r,1'r,2's)-5,6,7,8 Tetrahydrobiopterin not specified NOS1
Drugbank DB02727	N-Butyl-N'-Hydroxyguanidine not specified NOS1
Drugbank DB02944	Alpha-D-Mannose not specified NOS1
Drugbank DB02991	S-Ethyl-N-[4-(Trifluoromethyl)Phenyl]Iso ... not specified NOS1
Drugbank DB03014	Heme not specified NOS1
Drugbank DB03144	N-Omega-Hydroxy-L-Arginine not specified NOS1
Drugbank DB03147	Flavin-Adenine Dinucleotide not specified NOS1
Drugbank DB03247	Riboflavin Monophosphate not specified NOS1
Drugbank DB03449	N-(4-(2-((3-Chlorophenylmethyl)Amino)Eth ... not specified NOS1
Drugbank DB03461	2'-Monophosphoadenosine 5'-Diphosphoribo ... not specified NOS1
Drugbank DB03707	S-Ethyl-N-Phenyl-Isothiourea not specified NOS1
Drugbank DB03710	N5-(1-Imino-3-Butenyl)-L-Ornithine not specified NOS1
Drugbank DB03892	5-N-Allyl-Arginine not specified NOS1
Drugbank DB04223	Nitroarginine not specified NOS1
Drugbank DB08018	N-{(3S,4S)-4-[(6-AMINO-4-METHYLPYRIDIN-2 ... not specified NOS1
Drugbank DB08019	N-{(3R,4S)-4-[(6-amino-4-methylpyridin-2 ... not specified NOS1
Drugbank DB00155	L-Citrulline not specified NOS1
Drugbank DB01821	L-N(Omega)-Nitroarginine-2,4-L-Diaminobu ... not specified NOS1
Drugbank DB01942	Formic Acid not specified NOS1
Drugbank DB01997	3-Bromo-7-Nitroindazole not specified NOS1
Drugbank DB02027	N-{(4s)-4-Amino-5-[(2-Aminoethyl)Amino]P ... not specified NOS1
Drugbank DB02077	L-N(Omega)-Nitroarginine-(4r)-Amino-L-Pr ... not specified NOS1
Drugbank DB02143	N-Isopropyl-N'-Hydroxyguanidine not specified NOS1
Drugbank DB02644	N-Omega-Propyl-L-Arginine not specified NOS1
Drugbank DB02692	(6r,1'r,2's)-5,6,7,8 Tetrahydrobiopterin not specified NOS1
Drugbank DB02727	N-Butyl-N'-Hydroxyguanidine not specified NOS1
Drugbank DB02944	Alpha-D-Mannose not specified NOS1
Drugbank DB03014	Heme not specified NOS1
Drugbank DB03144	N-Omega-Hydroxy-L-Arginine not specified NOS1
Drugbank DB03147	Flavin-Adenine Dinucleotide not specified NOS1
Drugbank DB03247	Riboflavin Monophosphate not specified NOS1
Drugbank DB03461	2'-Monophosphoadenosine 5'-Diphosphoribo ... not specified NOS1
Drugbank DB03710	N5-(1-Imino-3-Butenyl)-L-Ornithine not specified NOS1
Drugbank DB03892	5-N-Allyl-Arginine not specified NOS1
Drugbank DB04223	Nitroarginine not specified NOS1

Comment	Acute tryptophan-depletion reduces nNOS activity as well as protein level.
Formal Description Interaction-ID: 47200	drug/chemical compound Tryptophan increases_quantity of gene/protein NOS1 in hippocampus
Drugbank entries	Show/Hide entries for NOS1
Drugbank DB00155	L-Citrulline not specified NOS1
Drugbank DB01821	L-N(Omega)-Nitroarginine-2,4-L-Diaminobu ... not specified NOS1
Drugbank DB01942	Formic Acid not specified NOS1
Drugbank DB01997	3-Bromo-7-Nitroindazole not specified NOS1
Drugbank DB02027	N-{(4s)-4-Amino-5-[(2-Aminoethyl)Amino]P ... not specified NOS1
Drugbank DB02044	N-(3-(Aminomethyl)Benzyl)Acetamidine not specified NOS1
Drugbank DB02077	L-N(Omega)-Nitroarginine-(4r)-Amino-L-Pr ... not specified NOS1
Drugbank DB02143	N-Isopropyl-N'-Hydroxyguanidine not specified NOS1
Drugbank DB02644	N-Omega-Propyl-L-Arginine not specified NOS1
Drugbank DB02692	(6r,1'r,2's)-5,6,7,8 Tetrahydrobiopterin not specified NOS1
Drugbank DB02727	N-Butyl-N'-Hydroxyguanidine not specified NOS1
Drugbank DB02944	Alpha-D-Mannose not specified NOS1
Drugbank DB02991	S-Ethyl-N-[4-(Trifluoromethyl)Phenyl]Iso ... not specified NOS1
Drugbank DB03014	Heme not specified NOS1
Drugbank DB03144	N-Omega-Hydroxy-L-Arginine not specified NOS1
Drugbank DB03147	Flavin-Adenine Dinucleotide not specified NOS1
Drugbank DB03247	Riboflavin Monophosphate not specified NOS1
Drugbank DB03449	N-(4-(2-((3-Chlorophenylmethyl)Amino)Eth ... not specified NOS1
Drugbank DB03461	2'-Monophosphoadenosine 5'-Diphosphoribo ... not specified NOS1
Drugbank DB03707	S-Ethyl-N-Phenyl-Isothiourea not specified NOS1
Drugbank DB03710	N5-(1-Imino-3-Butenyl)-L-Ornithine not specified NOS1
Drugbank DB03892	5-N-Allyl-Arginine not specified NOS1
Drugbank DB04223	Nitroarginine not specified NOS1
Drugbank DB08018	N-{(3S,4S)-4-[(6-AMINO-4-METHYLPYRIDIN-2 ... not specified NOS1
Drugbank DB08019	N-{(3R,4S)-4-[(6-amino-4-methylpyridin-2 ... not specified NOS1
Drugbank DB00155	L-Citrulline not specified NOS1
Drugbank DB01821	L-N(Omega)-Nitroarginine-2,4-L-Diaminobu ... not specified NOS1
Drugbank DB01942	Formic Acid not specified NOS1
Drugbank DB01997	3-Bromo-7-Nitroindazole not specified NOS1
Drugbank DB02027	N-{(4s)-4-Amino-5-[(2-Aminoethyl)Amino]P ... not specified NOS1
Drugbank DB02077	L-N(Omega)-Nitroarginine-(4r)-Amino-L-Pr ... not specified NOS1
Drugbank DB02143	N-Isopropyl-N'-Hydroxyguanidine not specified NOS1
Drugbank DB02644	N-Omega-Propyl-L-Arginine not specified NOS1
Drugbank DB02692	(6r,1'r,2's)-5,6,7,8 Tetrahydrobiopterin not specified NOS1
Drugbank DB02727	N-Butyl-N'-Hydroxyguanidine not specified NOS1
Drugbank DB02944	Alpha-D-Mannose not specified NOS1
Drugbank DB03014	Heme not specified NOS1
Drugbank DB03144	N-Omega-Hydroxy-L-Arginine not specified NOS1
Drugbank DB03147	Flavin-Adenine Dinucleotide not specified NOS1
Drugbank DB03247	Riboflavin Monophosphate not specified NOS1
Drugbank DB03461	2'-Monophosphoadenosine 5'-Diphosphoribo ... not specified NOS1
Drugbank DB03710	N5-(1-Imino-3-Butenyl)-L-Ornithine not specified NOS1
Drugbank DB03892	5-N-Allyl-Arginine not specified NOS1
Drugbank DB04223	Nitroarginine not specified NOS1

Comment	Serotonin (5-hydroxytryptamin, 5HT) is synthesized from its precursor tryptophan via tryptophan-5-monooxygenase (TPH) and aromatic-L-amino-acid decarboxylase (DDC).
Formal Description Interaction-ID: 47201	gene/protein TPH decreases_quantity of drug/chemical compound Tryptophan

Comment	Serotonin (5-hydroxytryptamin, 5HT) is synthesized from its precursor tryptophan via tryptophan-5-monooxygenase (TPH) and aromatic-L-amino-acid decarboxylase (DDC).
Formal Description Interaction-ID: 47202	gene/protein TPH increases_quantity of drug/chemical compound 5-Hydroxytryptophan

Comment	Serotonin (5-hydroxytryptamin, 5HT) is synthesized from its precursor tryptophan via tryptophan-5-monooxygenase (TPH) and aromatic-L-amino-acid decarboxylase (DDC).
Formal Description Interaction-ID: 47203	gene/protein DDC decreases_quantity of drug/chemical compound 5-Hydroxytryptophan
Drugbank entries	Show/Hide entries for DDC
Drugbank DB00114	Pyridoxal Phosphate cofactor DDC
Drugbank DB00114	Pyridoxal Phosphate cofactor DDC
Drugbank DB00114	Pyridoxal Phosphate cofactor DDC
Drugbank DB00190	Carbidopa inhibitor DDC
Drugbank DB00190	Carbidopa inhibitor DDC

Comment	Serotonin (5-hydroxytryptamin, 5HT) is synthesized from its precursor tryptophan via tryptophan-5-monooxygenase (TPH) and aromatic-L-amino-acid decarboxylase (DDC).
Formal Description Interaction-ID: 47204	gene/protein DDC increases_quantity of drug/chemical compound Serotonin
Drugbank entries	Show/Hide entries for DDC
Drugbank DB00114	Pyridoxal Phosphate cofactor DDC
Drugbank DB00114	Pyridoxal Phosphate cofactor DDC
Drugbank DB00114	Pyridoxal Phosphate cofactor DDC
Drugbank DB00190	Carbidopa inhibitor DDC
Drugbank DB00190	Carbidopa inhibitor DDC

Comment	Serotonin (5-hydroxytryptamin, 5HT) is synthesized from its precursor tryptophan via tryptophan-5-monooxygenase (TPH) and aromatic-L-amino-acid decarboxylase (DDC).
Formal Description Interaction-ID: 47778	gene/protein DDC decreases_quantity of drug/chemical compound Tryptophan
Drugbank entries	Show/Hide entries for DDC
Drugbank DB00114	Pyridoxal Phosphate cofactor DDC
Drugbank DB00114	Pyridoxal Phosphate cofactor DDC
Drugbank DB00114	Pyridoxal Phosphate cofactor DDC
Drugbank DB00190	Carbidopa inhibitor DDC
Drugbank DB00190	Carbidopa inhibitor DDC

Comment	Serotonin (5-hydroxytryptamin, 5HT) is synthesized from its precursor tryptophan via tryptophan-5-monooxygenase (TPH) and aromatic-L-amino-acid decarboxylase (DDC).
Formal Description Interaction-ID: 47779	gene/protein TPH increases_quantity of drug/chemical compound Serotonin

Comment	Serotonin (5-hydroxytryptamin, 5HT) is synthesized from its precursor tryptophan via tryptophan-5-monooxygenase (TPH) and aromatic-L-amino-acid decarboxylase (DDC).
Formal Description Interaction-ID: 47780	drug/chemical compound Tryptophan increases_quantity of drug/chemical compound Serotonin