General Information:

Id: 4,767
Diseases: Cardiovascular disease
Metabolic
Rattus norvegicus
article/cited
Reference: Breard M et al.(2007) The endogenous neurotransmitter, serotonin, modifies neuronal nitric oxide synthase activities Free Radic. Res. 41: 413-423 [PMID: 17454123]

Interaction Information:

Comment nNOS generates nitric oxide from arginine and in addition hydrogen peroxide (H2O2) and superoxide anion. In the presence of low levels of arginine the formation of superoxide anions in comparison to NO is elevated. (cited information)
Formal Description
Interaction-ID: 47189

gene/protein

NOS1

increases_quantity of

drug/chemical compound

NO

Drugbank entries Show/Hide entries for NOS1
Comment nNOS generates nitric oxide from arginine and in addition hydrogen peroxide (H2O2) and superoxide anion. In the presence of low levels of arginine the formation of superoxide anions in comparison to NO is elevated. (cited information)
Formal Description
Interaction-ID: 47190

gene/protein

NOS1

increases_quantity of

drug/chemical compound

O2-

especially in a medium with low arginine concentrations
Drugbank entries Show/Hide entries for NOS1
Comment nNOS generates nitric oxide from arginine and in addition hydrogen peroxide (H2O2) and superoxide anion. In the presence of low levels of arginine the formation of superoxide anions in comparison to NO is elevated. (cited information)
Formal Description
Interaction-ID: 47191

gene/protein

NOS1

increases_quantity of

drug/chemical compound

H2O2

Drugbank entries Show/Hide entries for NOS1
Comment NO was reported to act on serotonine (5HT) turnover by inhibiting the activity of tryptophan hydroxylase, the main enzyme involved in 5HT biosynthesis.
Formal Description
Interaction-ID: 47192

drug/chemical compound

NO

decreases_activity of

gene/protein

TPH

Comment Serotonine (5HT) induces the production of NO in endothelial cells. (cited information)
Formal Description
Interaction-ID: 47193

drug/chemical compound

Serotonin

increases_quantity of

drug/chemical compound

NO

in endothelial cells
Comment NO production by nNOS was not affected by low concentrations of serotonine (5HT). Whereas ROS production by nNOS was strongly increased.
Formal Description
Interaction-ID: 47194

drug/chemical compound

Serotonin

increases_quantity of

drug/chemical compound

Reactive oxygen species

if only low concentrations of serotonin were present
Comment 5HT induces an increase in nNOS activity under conditions where nNOS was shown to produce mainly H2O2 (in the absence of arginine and presence of BH4).
Formal Description
Interaction-ID: 47196

drug/chemical compound

Serotonin

increases_activity of

gene/protein

NOS1

in the absence of arginine
Drugbank entries Show/Hide entries for NOS1