General Information:

Id: 4,719 (click here to show other Interactions for entry)
Diseases: Neurological
Mammalia
review
Reference: Mao LM et al.(2011) Post-translational modification biology of glutamate receptors and drug addiction Front Neuroanat 5: 19 [PMID: 21441996]

Interaction Information:

Comment Dopamine is a strong regulator of the site-specific phosphorylation of striatal GluA1 subunits. By stimulating D1 dopamine receptors and associated cAMP/ PKA pathways, the D1 agonist and psychostimulants (cocaine and amphetamine) increased GluA1 phosphorylation preferentially at Ser845 in striatal neurons.
Formal Description
Interaction-ID: 46806

drug/chemical compound

Dopamine

increases_phosphorylation of

gene/protein

GRIA1

in striatal neurons; preferentially at Ser845
Drugbank entries Show/Hide entries for Dopamine or GRIA1