CIDeRplusGeneral Information:
| Id: | 46 |
| Diseases: |
Diabetes mellitus, type I
- [OMIM]
|
| Rattus norvegicus | |
| BTO:0000991 pancreatic islet | |
| article | |
| Reference: | Manna P et al.(2009) Protective role of arjunolic acid in response to streptozotocin-induced type-I diabetes via the mitochondrial dependent and independent pathways. Toxicology 257: 53-63 [PMID: 19133311] |
Interaction Information:
| Comment | STZ (Streptozotocin) exposure caused increase in serum glucose level and established the condition of oxidative stress. |
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Formal Description Interaction-ID: 122 |
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| Drugbank entries | Show/Hide entries for Streptozocin |
| Comment | STZ (Streptozotocin) exposure caused increase in serum glucose level and established the condition of oxidative stress. |
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Formal Description Interaction-ID: 126 |
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| Drugbank entries | Show/Hide entries for Streptozocin |
| Comment | STZ (Streptozotocin) intoxication increased the levels of serum TNF-alpha and NO under hyperglycemic condition. |
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Formal Description Interaction-ID: 127 |
drug/chemical compound increases_quantity of gene/protein |
| Drugbank entries | Show/Hide entries for Streptozocin or TNF |
| Comment | STZ (Streptozotocin) intoxication increased the levels of serum TNF-alpha and NO. |
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Formal Description Interaction-ID: 128 |
drug/chemical compound increases_quantity of drug/chemical compound |
| Drugbank entries | Show/Hide entries for Streptozocin |
| Comment | The addition of arjunolic acid (AA) to STZ treated rats could inhibit or reduce the serum glucose accumulation and decreased the serum NO and TNF-alpha levels. |
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Formal Description Interaction-ID: 129 |
drug/chemical compound Arjunolic acid decreases_quantity of drug/chemical compound |
| Comment | The addition of arjunolic acid (AA) to STZ treated rats could inhibit or reduce the serum glucose accumulation and decreased the serum NO and TNF-alpha levels. |
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Formal Description Interaction-ID: 131 |
drug/chemical compound Arjunolic acid decreases_quantity of gene/protein |
| Drugbank entries | Show/Hide entries for TNF |
| Comment | The addition of arjunolic acid (AA) to STZ treated rats could inhibit or reduce the serum glucose accumulation and decreased the serum NO and TNF-alpha levels. |
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Formal Description Interaction-ID: 132 |
drug/chemical compound Arjunolic acid decreases_quantity of drug/chemical compound |
| Comment | STZ intoxication increased the levels of MDA, lipid hydroperoxide and protein carbonylation in the pancreatic tissue of rats. |
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Formal Description Interaction-ID: 133 |
drug/chemical compound increases_quantity of drug/chemical compound |
| Drugbank entries | Show/Hide entries for Streptozocin |
| Comment | Arjunolic acid (AA) treatment both prior and post to the STZ exposure have found to be effective in inhibiting or reducing the STZ-induced pancreatic oxidative stress under hyperglycemic condition. |
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Formal Description Interaction-ID: 134 |
drug/chemical compound Arjunolic acid decreases_activity of process |
| Comment | STZ intoxication significantly attenuated the activities of the antioxidant enzymes (SOD, CAT, GST, GR, GPx, G6PD) compared to normal. |
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Formal Description Interaction-ID: 137 |
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| Drugbank entries | Show/Hide entries for Streptozocin or SOD1 |
| Comment | Arjunolic acid (AA) treatment inhibited or reduced the STZ-induced decreased activities of the antioxidant enzymes (SOD, CAT, GST, GR, GPx, G6PD). |
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Formal Description Interaction-ID: 139 |
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| Drugbank entries | Show/Hide entries for SOD1 |
| Comment | STZ intoxication significantly attenuated the activities of the antioxidant enzymes (SOD, CAT, GST, GR, GPx, G6PD) compared to normal. |
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Formal Description Interaction-ID: 141 |
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| Drugbank entries | Show/Hide entries for Streptozocin or CAT |
| Comment | Arjunolic acid (AA) treatment inhibited or reduced the STZ-induced decreased activities of the antioxidant enzymes (SOD, CAT, GST, GR, GPx, G6PD). |
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Formal Description Interaction-ID: 142 |
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| Drugbank entries | Show/Hide entries for CAT |
| Comment | STZ intoxication significantly attenuated the activities of the antioxidant enzymes (SOD, CAT, GST, GR, GPx, G6PD) compared to normal. |
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Formal Description Interaction-ID: 143 |
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| Drugbank entries | Show/Hide entries for Streptozocin or GSR |
| Comment | Arjunolic acid (AA) treatment inhibited or reduced the STZ-induced decreased activities of the antioxidant enzymes (SOD, CAT, GST, GR, GPx, G6PD). |
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Formal Description Interaction-ID: 144 |
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| Drugbank entries | Show/Hide entries for GSR |
| Comment | STZ intoxication significantly attenuated the activities of the antioxidant enzymes (SOD, CAT, GST, GR, GPx, G6PD) compared to normal. |
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Formal Description Interaction-ID: 145 |
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| Drugbank entries | Show/Hide entries for Streptozocin or GPX1 |
| Comment | Arjunolic acid (AA) treatment inhibited or reduced the STZ-induced decreased activities of the antioxidant enzymes (SOD, CAT, GST, GR, GPx, G6PD). |
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Formal Description Interaction-ID: 146 |
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| Drugbank entries | Show/Hide entries for GPX1 |
| Comment | STZ intoxication significantly attenuated the activities of the antioxidant enzymes (SOD, CAT, GST, GR, GPx, G6PD) compared to normal. |
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Formal Description Interaction-ID: 147 |
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| Drugbank entries | Show/Hide entries for Streptozocin or G6PD |
| Comment | Arjunolic acid (AA) treatment inhibited or reduced the STZ-induced decreased activities of the antioxidant enzymes (SOD, CAT, GST, GR, GPx, G6PD). |
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Formal Description Interaction-ID: 148 |
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| Drugbank entries | Show/Hide entries for G6PD |
| Comment | STZ intoxication significantly attenuated the activities of the antioxidant enzymes (SOD, CAT, GST, GR, GPx, G6PD) compared to normal. |
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Formal Description Interaction-ID: 150 |
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| Drugbank entries | Show/Hide entries for Streptozocin or GSTK1 |
| Comment | Arjunolic acid (AA) treatment inhibited or reduced the STZ-induced decreased activities of the antioxidant enzymes (SOD, CAT, GST, GR, GPx, G6PD). |
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Formal Description Interaction-ID: 152 |
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| Drugbank entries | Show/Hide entries for GSTK1 |
| Comment | STZ intoxication induced the expression of NF-kappa-B (p65). |
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Formal Description Interaction-ID: 153 |
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| Drugbank entries | Show/Hide entries for Streptozocin or RELA |
| Comment | Arjunolic acid (AA) treatment down-regulated NF-kappa-B (p65) induced by STZ. |
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Formal Description Interaction-ID: 154 |
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| Drugbank entries | Show/Hide entries for RELA |
| Comment | STZ administration significantly attenuated the mitochondrial transmembrane potential, elevated the concentration of cytosolic cytochrome c and simultaneously increased the caspase 3 activity. |
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Formal Description Interaction-ID: 157 |
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| Drugbank entries | Show/Hide entries for Streptozocin or CASP3 |
| Comment | STZ administration significantly attenuated the mitochondrial transmembrane potential, elevated the concentration of cytosolic cytochrome c and simultaneously increased the caspase 3 activity. |
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Formal Description Interaction-ID: 158 |
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| Drugbank entries | Show/Hide entries for Streptozocin or CYCS |
| Comment | Arjunolic acid (AA) treatment both prior and post to the STZ administration however could significantly inhibit STZ-induced cytosolic cytochrome c release and caspase 3 activity. |
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Formal Description Interaction-ID: 159 |
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| Drugbank entries | Show/Hide entries for CASP3 |
| Comment | Arjunolic acid (AA) treatment both prior and post to the STZ administration however could significantly inhibit STZ-induced cytosolic cytochrome c release and caspase 3 activity. |
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Formal Description Interaction-ID: 161 |
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| Drugbank entries | Show/Hide entries for CYCS |