CIDeRplusGeneral Information:
| Id: | 4,596 (click here to show other Interactions for entry) |
| Diseases: |
Diabetes mellitus, type II
- [OMIM]
Insulin resistance |
| Homo sapiens | |
| article | |
| Reference: | Grasfeder LL et al.(2009) Fasting-induced hepatic production of DHEA is regulated by PGC-1alpha, ERRalpha, and HNF4alpha Mol. Endocrinol. 8: 1171-1182 [PMID: 19389810] |
Interaction Information:
| Comment | The study tested whether low concentrations of dehydroepiandrosterone (DHEA) might have an impact on any relevant metabolic markers in hepatic cells. HepG2 cells were treated with 1 nM DHEA, and tandem mass spectrometry was used to measure various metabolic parameters of the cells, including acylcarnitines and amino acids. No changes in acylcarnitines were evident. However, although glycine, serine, proline, and aspartate levels did not change in treated cells, we reproducibly observed that the levels of alanine, arginine, valine, leucine, isoleucine, tyrosine, phenylalanine, methionine, and histidine levels were reduced about 50% by 1 nM DHEA. |
|
Formal Description Interaction-ID: 45740 |
drug/chemical compound NOT affects_quantity of drug/chemical compound |
| Drugbank entries | Show/Hide entries for Dehydroepiandrosterone or Glycine |