General Information:

Id: 448 (click here to show other Interactions for entry)
Diseases: Parkinson disease
Drosophila melanogaster
BTO:0000142 brain
article
Reference: Imai Y et al.(2008) Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila EMBO J. 27: 2432-2443 [PMID: 18701920]

Interaction Information:

Comment Flies expressing LRRK-mutants showed significantly higher sensitivity to exogenous ROS inducers paraquat and H(2)O(2).
Formal Description
Interaction-ID: 1987

gene/protein mutant

LRRK2-mut

increases_activity of

process

response to oxidative stress

Comment Blockage of 4E-BP phosphorylation and the consequent tighter binding and stronger inhibition of eIF4E lead to higher stress response. Overexpression of eIF4E significantly sensitizied animals to oxidative stress response, similar to the effect induced by mutant dLRRK overexpression.
Formal Description
Interaction-ID: 2002

gene/protein

EIF4EBP1

affects_activity of

process

response to oxidative stress