General Information:

Id: 4,466
Diseases: Metabolic
Neurological
Mus musculus
article
Reference: Roy M et al.(2006) Genetic inactivation of melanin-concentrating hormone receptor subtype 1 (MCHR1) in mice exerts anxiolytic-like behavioral effects Neuropsychopharmacology 31: 112-120 [PMID: 15988472]

Interaction Information:

Comment Baseline dialysate 5-HT levels were significantly lower in MCHR1 knockout mice as compared with wild-type controls in the prefrontal cortex (PFC), one of the main target structures of the serotonergic system.
Formal Description
Interaction-ID: 45002

gene/protein

MCHR1

increases_quantity of

drug/chemical compound

Serotonin

in the prefrontal cortex (PFC)
Comment Baseline dialysate 5-HT levels were significantly lower in MCHR1 knockout mice as compared with wild-type controls in the prefrontal cortex (PFC), one of the main target structures of the serotonergic system.
Formal Description
Interaction-ID: 106723

cellular component

serotonergic system

affects_activity of

tissue/cell line

prefrontal cortex

Comment Baseline dialysate 5-HT levels were significantly lower in MCHR1 knockout mice as compared with wild-type controls in the prefrontal cortex (PFC), one of the main target structures of the serotonergic system.
Formal Description
Interaction-ID: 106724

organism model

MCHR1 KO mouse

decreases_quantity of

drug/chemical compound

Serotonin

in the prefrontal cortex (PFC); compared with wild-type controls
Comment Baseline dialysate 5-HT levels were significantly lower in MCHR1 knockout mice as compared with wild-type controls in the prefrontal cortex (PFC), one of the main target structures of the serotonergic system.
Formal Description
Interaction-ID: 139771

organism model

MCHR1 KO mouse

decreases_quantity of

gene/protein

MCHR1