General Information:

Id: 4,463 (click here to show other Interactions for entry)
Diseases: Metabolic
Mammalia
article
Reference: Rooke N et al.(2000) The mitochondrial monoamine oxidase-aldehyde dehydrogenase pathway: a potential site of action of daidzin J. Med. Chem. 43: 4169-4179 [PMID: 11063613]

Interaction Information:

Comment MAO and ALDH-2 act in tandem in the catalytic conversion of 5-HT (serotonin) to 5-HIAA (5-hydroxyindole-3-acetic acid) in isolated mitochondria. The MAO/ALDH-2 pathway is the major pathway that catalyzes monoamine metabolism in mitochondria. Daidzin is a potent inhibitor of ALDH-2, but not of MAO activity.
Formal Description
Interaction-ID: 44992

gene/protein

ALDH2

decreases_quantity of

drug/chemical compound

Serotonin

in hamster liver mitochondria; to 5-HIAA (5-hydroxyindole-3-acetic acid)
Drugbank entries Show/Hide entries for ALDH2