General Information:

Id: 441
Diseases: Epilepsy
Rattus norvegicus
Sprague-Dawley
BTO:0003036 hippocampal cell line
article
Reference: Pal S et al.(2001) Epileptogenesis induces long-term alterations in intracellular calcium release and sequestration mechanisms in the hippocampal neuronal culture model of epilepsy. Cell Calcium 30: 285-296 [PMID: 11587552]

Interaction Information:

Comment The glutamate-treatment (50 mM) for 2 min increases Ca2+ load in normal and epileptic neurons.
Formal Description
Interaction-ID: 1941

drug/chemical compound

Glutamate

increases_activity of

complex/PPI

Glutamate-gated calcium ion channel complex

Comment A period of 30 min after the stimulus, control cells recovered to basal levels of [Ca2+]i that were not statistically significantly different from the initial levels prior to glutamate treatment. However, the [Ca2+]i levels in the epileptic cells were still slightly elevated above initial base line levels 40 min after the glutamate stimulatio.
Formal Description
Interaction-ID: 13796

drug/chemical compound

Glutamate

increases_quantity of

drug/chemical compound

Ca2+

in epileptic neurons
Comment The sequestration of [Ca2+]i was significantly decreased in epileptic neurons.
Formal Description
Interaction-ID: 13797

disease

Epilepsy

decreases_activity of

process

sequestering of calcium ion

in epileptic neurons
Comment Ca2+ induced Ca2+ release (CICR) was significantly augmented in the epileptic neurons.
Formal Description
Interaction-ID: 13798

disease

Epilepsy

increases_activity of

process

calcium-induced calcium release

in epileptic neurons
Comment It was determined that the IP3 receptor mediated CICR was the major release mechanism altered in epileptogenesis.
Formal Description
Interaction-ID: 13799

process

epileptogenesis

affects_activity of

process

inositol 1,4,5-trisphosphate-sensitive calcium-release

in epileptic neurons