CIDeRplusGeneral Information:
| Id: | 4,285 (click here to show other Interactions for entry) |
| Diseases: |
Diabetes mellitus, type II
- [OMIM]
Insulin resistance Schizophrenia - [OMIM] |
| Mus musculus | |
| female | |
| article | |
| Reference: | Schmidt RH et al.(2013) Olanzapine activates hepatic mammalian target of rapamycin: new mechanistic insight into metabolic dysregulation with atypical antipsychotic drugs J. Pharmacol. Exp. Ther. 347: 126-135 [PMID: 23926289] |
Interaction Information:
| Comment | Amino acids were significantly affected by olanzapine (OLZ): L-glutamine, a putative mediator of mTOR activation, was increased in animals administered OLZ. OLZ also caused a decrease in L-leucine and a parallel increase in L-glutamate, which can act as nitrogen donor and nitrogen acceptor, respectively, in the transamination reaction that regulates the glutamate-glutamine cycle. |
|
Formal Description Interaction-ID: 46104 |
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| Drugbank entries | Show/Hide entries for Olanzapine |