General Information:

Id: 427 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mus musculus
BTO:0000165 C2C12 cell
article
Reference: Lee HK et al.(2009) The insulin/Akt signaling pathway is targeted by intracellular beta-amyloid Mol. Biol. Cell 20: 1533-1544 [PMID: 19144826]

Interaction Information:

Comment In cell culture, intraneuronal beta-amyloid expression inhibited both insulin-induced Akt phosphorylation and activity.
Formal Description
Interaction-ID: 1867

gene/protein

Amyloid beta peptide

decreases_phosphorylation of

gene/protein

AKT1

if AKT is insulin-induced;
Drugbank entries Show/Hide entries for AKT1
Comment In cell culture, intraneuronal beta-amyloid expression inhibited both insulin-induced Akt phosphorylation and activity.
Formal Description
Interaction-ID: 1868

gene/protein

Amyloid beta peptide

decreases_activity of

gene/protein

AKT1

if AKT is insulin-induced;
Drugbank entries Show/Hide entries for AKT1
Comment Intraneuronal beta-amyloid blocked the association between PDK and Akt in cell-based and in vitro experiments.
Formal Description
Interaction-ID: 1883

gene/protein

AKT1

interacts (colocalizes) with

gene/protein

PDPK1

via intraneuronal beta-amyloid
Drugbank entries Show/Hide entries for AKT1 or PDPK1
Comment The stimulated activity of Akt1 on the GSK substrate is markedly inhibited in the presence of intracellular beta-amyloid42.
Formal Description
Interaction-ID: 2001

gene/protein

Amyloid beta peptide (42)

decreases_activity of

gene/protein

AKT1

concerning activity of Akt1 on the GSK substrate
Drugbank entries Show/Hide entries for AKT1
Comment Intraneuronal beta-amyloid blocked the association between PDK and Akt in cell-based and in vitro experiments. The interaction of PDK with Akt1 is interrupted by intracellular beta-amyloid42.
Formal Description
Interaction-ID: 2004

gene/protein

AKT1

is_part_of

complex/PPI

AKT1-PDPK1 interaction

Drugbank entries Show/Hide entries for AKT1
Comment In cell culture, intraneuronal beta-amyloid expression inhibited both insulin-induced Akt phosphorylation and activity.
Formal Description
Interaction-ID: 129312

complex/PPI

Insulin

increases_phosphorylation of

gene/protein

AKT1

in cell culture
Drugbank entries Show/Hide entries for AKT1
Comment In cell culture, intraneuronal beta-amyloid expression inhibited both insulin-induced Akt phosphorylation and activity.
Formal Description
Interaction-ID: 134780

protein modification

AKT1-phos

increases_activity of

gene/protein

AKT1

in cell culture; inhibited by intraneuronal beta-amyloid expression
Drugbank entries Show/Hide entries for AKT1