General Information:

Id: 427 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mus musculus
BTO:0000165 C2C12 cell
article
Reference: Lee HK et al.(2009) The insulin/Akt signaling pathway is targeted by intracellular beta-amyloid Mol. Biol. Cell 20: 1533-1544 [PMID: 19144826]

Interaction Information:

Comment In cell culture, intraneuronal beta-amyloid expression inhibited both insulin-induced Akt phosphorylation and activity.
Formal Description
Interaction-ID: 1867

gene/protein

Amyloid beta peptide

decreases_phosphorylation of

gene/protein

AKT1

if AKT is insulin-induced;
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