General Information:

Id: 418 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
brain
article
Reference: Lee HK et al.(2009) The insulin/Akt signaling pathway is targeted by intracellular beta-amyloid. Mol. Biol. Cell 20: 1533-1544 [PMID: 19144826]

Interaction Information:

Comment Ser473 phosphorylation is required for full Akt activity and precedes the phosphorylation of Thr308 by PDK-1.
Formal Description
Interaction-ID: 1976

gene/protein

PDPK1

increases_phosphorylation of

gene/protein

AKT1

at Thr308; phosphorylation at Ser473 is required for full Akt activity;
Drugbank entries Show/Hide entries for PDPK1 or AKT1