General Information:

Id: 418 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
brain
article
Reference: Lee HK et al.(2009) The insulin/Akt signaling pathway is targeted by intracellular beta-amyloid. Mol. Biol. Cell 20: 1533-1544 [PMID: 19144826]

Interaction Information:

Comment One possibility for the down-regulation of Akt activation in AD brain is direct inhibition mediated by an increase in cellular beta-amyloid.
Formal Description
Interaction-ID: 1954

gene/protein

Amyloid beta peptide

decreases_activity of

gene/protein

AKT1

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