General Information:

Id: 418 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
brain
article
Reference: Lee HK et al.(2009) The insulin/Akt signaling pathway is targeted by intracellular beta-amyloid. Mol. Biol. Cell 20: 1533-1544 [PMID: 19144826]

Interaction Information:

Comment AKT1 interacts with PDPK1.
Formal Description
Interaction-ID: 1890

gene/protein

AKT1

interacts (colocalizes) with

gene/protein

PDPK1

Drugbank entries Show/Hide entries for AKT1 or PDPK1
Comment AKT1 is localized in brain.
Formal Description
Interaction-ID: 1943

gene/protein

AKT1

is localized in

tissue/cell line

brain

Drugbank entries Show/Hide entries for AKT1
Comment One possibility for the down-regulation of Akt activation in AD brain is direct inhibition mediated by an increase in cellular beta-amyloid.
Formal Description
Interaction-ID: 1954

gene/protein

Amyloid beta peptide

decreases_activity of

gene/protein

AKT1

Drugbank entries Show/Hide entries for AKT1
Comment The association of beta-amyloid with each of Akt1 and PDK was increased in AD brain. Beta-amyloid has specific affinity for PDK/Akt.
Formal Description
Interaction-ID: 1955

gene/protein

Amyloid beta peptide

interacts (colocalizes) with

gene/protein

AKT1

Drugbank entries Show/Hide entries for AKT1
Comment Ser473 phosphorylation is required for full Akt activity and precedes the phosphorylation of Thr308 by PDK-1.
Formal Description
Interaction-ID: 1976

gene/protein

PDPK1

increases_phosphorylation of

gene/protein

AKT1

at Thr308; phosphorylation at Ser473 is required for full Akt activity;
Drugbank entries Show/Hide entries for PDPK1 or AKT1