CIDeRplusGeneral Information:
| Id: | 418 |
| Diseases: |
Alzheimer disease
- [OMIM]
|
| Homo sapiens | |
| brain | |
| article | |
| Reference: | Lee HK et al.(2009) The insulin/Akt signaling pathway is targeted by intracellular beta-amyloid. Mol. Biol. Cell 20: 1533-1544 [PMID: 19144826] |
Interaction Information:
| Comment | Type II diabetes and peripheral insulin resistance are risk factors for Alzheimer disease. |
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Formal Description Interaction-ID: 1830 |
|
| Comment | Type II diabetes and peripheral insulin resistance are risk factors for Alzheimer disease. |
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Formal Description Interaction-ID: 1834 |
phenotype increases_activity of disease |
| Comment | Intraneuronal beta-amyloid accumulates early in Alzheimer disease and inclusion body myositis. |
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Formal Description Interaction-ID: 1876 |
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| Comment | In Alzheimer brain the association between PDK and Akt, phospho-Akt levels and its activity were all decreased relative to control. |
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Formal Description Interaction-ID: 1878 |
|
| Comment | AKT1 interacts with PDPK1. |
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Formal Description Interaction-ID: 1890 |
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| Drugbank entries | Show/Hide entries for AKT1 or PDPK1 |
| Comment | The Akt-1-binding partner HSP27 showed no changes in interaction level with disease state. |
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Formal Description Interaction-ID: 1892 |
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| Comment | AKT1 is localized in brain. |
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Formal Description Interaction-ID: 1943 |
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| Drugbank entries | Show/Hide entries for AKT1 |
| Comment | In AD frontal lobe, p-Akt (Thr308) levels were decreased relative to control. |
|
Formal Description Interaction-ID: 1950 |
disease decreases_quantity of protein modification AKT1-phosThr308 |
| Comment | One possibility for the down-regulation of Akt activation in AD brain is direct inhibition mediated by an increase in cellular beta-amyloid. |
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Formal Description Interaction-ID: 1954 |
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| Drugbank entries | Show/Hide entries for AKT1 |
| Comment | The association of beta-amyloid with each of Akt1 and PDK was increased in AD brain. Beta-amyloid has specific affinity for PDK/Akt. |
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Formal Description Interaction-ID: 1955 |
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| Drugbank entries | Show/Hide entries for AKT1 |
| Comment | Another kinase with activity to regulate GSK, PKA, was not affected in the AD samples, confirming specificity. |
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Formal Description Interaction-ID: 1973 |
|
| Comment | Ser473 phosphorylation is required for full Akt activity and precedes the phosphorylation of Thr308 by PDK-1. |
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Formal Description Interaction-ID: 1976 |
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| Drugbank entries | Show/Hide entries for PDPK1 or AKT1 |
| Comment | Phosphorylation of tau and neurofilament proteins are elevated in AD. |
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Formal Description Interaction-ID: 1983 |
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| Comment | Phosphorylation of tau and neurofilament proteins are elevated in AD. |
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Formal Description Interaction-ID: 1984 |
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| Comment | The association of beta-amyloid with each of Akt1 and PDK was increased in AD brain. |
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Formal Description Interaction-ID: 14040 |
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| Drugbank entries | Show/Hide entries for PDPK1 |
| Comment | Intraneuronal beta-amyloid accumulates early in Alzheimer disease and inclusion body myositis. |
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Formal Description Interaction-ID: 14041 |
|
| Comment | In Alzheimer brain the association between PDK and Akt, phospho-Akt levels and its activity were all decreased relative to control. |
|
Formal Description Interaction-ID: 50452 |
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