CIDeRplusGeneral Information:
| Id: | 4,118 (click here to show other Interactions for entry) |
| Diseases: |
Multiple sclerosis
- [OMIM]
|
| Mammalia | |
| review | |
| Reference: | Arnason BG et al.(2013) Mechanisms of action of adrenocorticotropic hormone and other melanocortins relevant to the clinical management of patients with multiple sclerosis Mult. Scler. 19: 130-136 [PMID: 23034287] |
Interaction Information:
| Comment | LC (locus ceruleus) ablation causes NA depletion throughout the cortex and frees microglia to make proinflammatory cytokines. Thus, decreased LC metabolism in MS links to cognitive impairment. |
|
Formal Description Interaction-ID: 42581 |
tissue/cell line affects_quantity of drug/chemical compound |