Arnason BG et al.(2013) Mechanisms of action of adrenocorticotropic hormone and other melanocortins relevant to the clinical management of patients with multiple sclerosis Mult. Scler. 19: 130-136
[PMID: 23034287]
Interaction Information:
Comment
Stimulation of brain-expressed MC4Rs increases central release of neurotransmitters (e.g. noradrenalin (NA), acetylcholine (ACh), dopamine (DA)) that can quell microglia and, via descending neural pathways, triggers release in the periphery of anti-inflammatory NA and ACh from sympathetic and parasympathetic nerve endings.
CIDeRplus