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Field	Query

	Field	Term

General Information:

Id:	4,113
Diseases:	Major depressive disorder - [OMIM]
Organism:	Mus musculus
Tissue/Cell line:	BTO:0000478 forebrain
Publication type:	article
Reference:	Guo M et al.(2012) Forebrain glutamatergic neurons mediate leptin action on depression-like behaviors and synaptic depression Transl Psychiatry 2: E83 [PMID: 22408745]

Interaction Information:

Comment	Lepr cKO mice exhibit normal growth and body weight. Behavioral characterization of Lepr cKO mice reveals depression-like behavioral deficits, including anhedonia, behavioral despair, enhanced learned helplessness and social withdrawal, with no evident signs of anxiety.
Formal Description Interaction-ID: 42406	gene/protein LEPR affects_activity of phenotype abnormal depression-related behavior

Comment	In addition, loss of Lepr in forebrain glutamatergic neurons facilitates NMDA-induced hippocampal long-term synaptic depression (LTD).
Formal Description Interaction-ID: 42408	gene/protein LEPR affects_activity of complex/PPI NMDA receptor complex

Comment	In addition, loss of Lepr in forebrain glutamatergic neurons facilitates NMDA-induced hippocampal long-term synaptic depression (LTD).
Formal Description Interaction-ID: 42409	gene/protein LEPR affects_activity of process synaptic transmission, glutamatergic

Comment	In addition, loss of Lepr in forebrain glutamatergic neurons facilitates NMDA-induced hippocampal long-term synaptic depression (LTD).
Formal Description Interaction-ID: 42410	drug/chemical compound Glutamate interacts (colocalizes) with complex/PPI NMDA receptor complex

Comment	In addition, loss of Lepr in forebrain glutamatergic neurons facilitates NMDA-induced hippocampal long-term synaptic depression (LTD).
Formal Description Interaction-ID: 42411	complex/PPI NMDA receptor complex affects_activity of process synaptic transmission, glutamatergic

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