General Information:

Id: 406
Diseases: Neurological
Status epilepticus
Mus musculus
M1 receptor KO mouse
article
Reference: Bymaster FP et al.(2003) Role of specific muscarinic receptor subtypes in cholinergic parasympathomimetic responses, in vivo phosphoinositide hydrolysis, and pilocarpine-induced seizure activity. Eur. J. Neurosci. 17: 1403-1410 [PMID: 12713643]

Interaction Information:

Comment The pilocarpine interacts with muscarinic M1 receptor.
Formal Description
Interaction-ID: 1740

drug/chemical compound

Pilocarpine

interacts (colocalizes) with

gene/protein

CHRM1

in pilocarpine model
Drugbank entries Show/Hide entries for Pilocarpine or CHRM1
Comment Muscarinic M1 receptors appear to be the only muscarinic receptor subtype mediating seizures.
Formal Description
Interaction-ID: 1745

gene/protein

CHRM1

affects_activity of

phenotype

convulsive seizures

in pilocarpine model
Drugbank entries Show/Hide entries for CHRM1
Comment Muscarinic M1 receptors activate phosphoinositide hydrolysis (phosphoinositidase C activity) in cortex and hippocampus.
Formal Description
Interaction-ID: 1746

gene/protein

CHRM1

increases_activity of

gene/protein

PLCG1

in pilocarpine model
Drugbank entries Show/Hide entries for CHRM1