CIDeRplusGeneral Information:
| Id: | 4,033 (click here to show other Interactions for entry) |
| Diseases: |
Diabetes mellitus, type II
- [OMIM]
Insulin resistance Parkinson disease |
| Homo sapiens | |
| article | |
| Reference: | Gieger C et al.(2008) Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum PLoS Genet. 4 [PMID: 19043545] |
Interaction Information:
| Comment | SNP rs4775041 is located in a linkage disequilibrium block containing the gene coding for LIPC, a key enzyme of the long-chain fatty acid metabolism. This polymorphism associates with the concentrations of numerous glycerophosphatidylcholines, glycerophosphatidylethanolamines and sphingomyelins. Homozygotes carrying the minor allele have on average 70% higher concentrations of the phosphatidylethanolamine diacyl C38:6 (PE aa C38:6) than homozygotes for the major allele. The molecular function of LIPC is to break-down triglycerides to diacyl- and monoacylglycerols and fatty acids, which makes this association functionally plausible. In previous GWA studies this locus was reported to be associated with HDL cholesterol and triglyceride levels. |
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Formal Description Interaction-ID: 41645 |
SNP decreases_quantity of drug/chemical compound |