CIDeRplusGeneral Information:
| Id: | 3,992 |
| Diseases: |
Diabetes mellitus, type II
- [OMIM]
Insulin resistance |
| Mammalia | |
| article/cited | |
| Reference: | Connor SC et al.(2010) Integration of metabolomics and transcriptomics data to aid biomarker discovery in type 2 diabetes Mol Biosyst 5: 909-921 [PMID: 20567778] |
Interaction Information:
| Comment | N-Acetylaspartate is a derivative of aspartic acid. (cited information) |
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Formal Description Interaction-ID: 40612 |
process alanine and aspartate metabolic process affects_quantity of drug/chemical compound |
| Comment | Mucic acid is a metabolite of the ascorbate and aldarate metabolism. (cited information) |
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Formal Description Interaction-ID: 40613 |
process ascorbate and aldarate metabolic process affects_quantity of drug/chemical compound |
| Comment | Phosphocreatine, creatinine, glycine, and guanidinoacetate are metabolites of the creatine biosynthesis and amino acid metabolism, and the glycine, serine and threonine metabolism. (cited information) |
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Formal Description Interaction-ID: 40618 |
process creatine biosynthetic process and amino acid metabolic process affects_quantity of drug/chemical compound |
| Comment | Phosphocreatine, creatinine, glycine, and guanidinoacetate are metabolites of the creatine biosynthesis and amino acid metabolism, and the glycine, serine and threonine metabolism. (cited information) |
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Formal Description Interaction-ID: 40619 |
process creatine biosynthetic process and amino acid metabolic process affects_quantity of drug/chemical compound |
| Comment | Phosphocreatine, creatinine, glycine, and guanidinoacetate are metabolites of the creatine biosynthesis and amino acid metabolism, and the glycine, serine and threonine metabolism. (cited information) |
|
Formal Description Interaction-ID: 40620 |
process creatine biosynthetic process and amino acid metabolic process affects_quantity of drug/chemical compound |
| Drugbank entries | Show/Hide entries for |
| Comment | Phosphocreatine, creatinine, glycine, and guanidinoacetate are metabolites of the creatine biosynthesis and amino acid metabolism, and the glycine, serine and threonine metabolism. (cited information) |
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Formal Description Interaction-ID: 40621 |
process creatine biosynthetic process and amino acid metabolic process affects_quantity of drug/chemical compound |
| Comment | Phosphocreatine, creatinine, glycine, and guanidinoacetate are metabolites of the creatine biosynthesis and amino acid metabolism, and the glycine, serine and threonine metabolism. (cited information) |
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Formal Description Interaction-ID: 40622 |
process glycine, serine and threonine metabolic process affects_quantity of drug/chemical compound |
| Comment | Phosphocreatine, creatinine, glycine, and guanidinoacetate are metabolites of the creatine biosynthesis and amino acid metabolism, and the glycine, serine and threonine metabolism. (cited information) |
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Formal Description Interaction-ID: 40623 |
process glycine, serine and threonine metabolic process affects_quantity of drug/chemical compound |
| Comment | Phosphocreatine, creatinine, glycine, and guanidinoacetate are metabolites of the creatine biosynthesis and amino acid metabolism, and the glycine, serine and threonine metabolism. (cited information) |
|
Formal Description Interaction-ID: 40624 |
process glycine, serine and threonine metabolic process affects_quantity of drug/chemical compound |
| Drugbank entries | Show/Hide entries for |
| Comment | Phosphocreatine, creatinine, glycine, and guanidinoacetate are metabolites of the creatine biosynthesis and amino acid metabolism, and the glycine, serine and threonine metabolism. (cited information) |
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Formal Description Interaction-ID: 40625 |
process glycine, serine and threonine metabolic process affects_quantity of drug/chemical compound |
| Comment | Butyrylglycine, malonate, carnitine, 2-hydroxy-N-valerate and caproylglycine are metabolites of the fatty acid metabolism. (cited information) |
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Formal Description Interaction-ID: 40631 |
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| Comment | Butyrylglycine, malonate, carnitine, 2-hydroxy-N-valerate and caproylglycine are metabolites of the fatty acid metabolism. (cited information) |
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Formal Description Interaction-ID: 40632 |
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| Comment | Butyrylglycine, malonate, carnitine, 2-hydroxy-N-valerate and caproylglycine are metabolites of the fatty acid metabolism. (cited information) |
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Formal Description Interaction-ID: 40633 |
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| Comment | Butyrylglycine, malonate, carnitine, 2-hydroxy-N-valerate and caproylglycine are metabolites of the fatty acid metabolism. (cited information) |
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Formal Description Interaction-ID: 40634 |
process affects_quantity of drug/chemical compound 2-Hydroxyvaleric acid |
| Comment | Butyrylglycine, malonate, carnitine, 2-hydroxy-N-valerate and caproylglycine are metabolites of the fatty acid metabolism. (cited information) |
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Formal Description Interaction-ID: 40635 |
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| Comment | N-Acetylglutamate is a metabolite of the glutamate pathway (link with urea cycle). (cited information) |
|
Formal Description Interaction-ID: 40637 |
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| Drugbank entries | Show/Hide entries for |
| Comment | Choline, threonine, and valerylglycine are metabolites of the glycine, serine and threonine metabolism. (cited information) |
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Formal Description Interaction-ID: 40641 |
process glycine, serine and threonine metabolic process affects_quantity of drug/chemical compound |
| Drugbank entries | Show/Hide entries for |
| Comment | Choline, threonine, and valerylglycine are metabolites of the glycine, serine and threonine metabolism. (cited information) |
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Formal Description Interaction-ID: 40642 |
process glycine, serine and threonine metabolic process affects_quantity of drug/chemical compound |
| Comment | Choline, threonine, and valerylglycine are metabolites of the glycine, serine and threonine metabolism. (cited information) |
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Formal Description Interaction-ID: 40643 |
process glycine, serine and threonine metabolic process affects_quantity of drug/chemical compound Valerylglycine |
| Comment | Glucose and lactate are metabolites of the glycolysis. (cited information) |
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Formal Description Interaction-ID: 40646 |
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| Comment | Glucose and lactate are metabolites of the glycolysis. (cited information) |
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Formal Description Interaction-ID: 40647 |
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| Comment | Alanine is a metabolite of the glycolysis and the alanine and aspartate metabolism. (cited information) |
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Formal Description Interaction-ID: 40651 |
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| Comment | Alanine is a metabolite of the glycolysis and the alanine and aspartate metabolism. (cited information) |
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Formal Description Interaction-ID: 40652 |
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| Comment | Acetate is a metabolite of the glycolysis and the fatty acid beta-oxidation. (cited information) |
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Formal Description Interaction-ID: 40653 |
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| Comment | Acetate is a metabolite of the glycolysis and the fatty acid beta-oxidation. (cited information) |
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Formal Description Interaction-ID: 40654 |
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| Comment | Formate is a metabolite of the glyoxylate and dicarboxylate metabolism. (cited information) |
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Formal Description Interaction-ID: 40655 |
process glyoxylate and dicarboxylate metabolic process affects_quantity of drug/chemical compound |
| Comment | 2-Oxoadipate is a metabolite of the lysine degradation. (cited information) |
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Formal Description Interaction-ID: 40660 |
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| Comment | Lysine is a metabolite of the lysine degradation and the aminoacyl tRNA biosynthesis. (cited information) |
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Formal Description Interaction-ID: 40661 |
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| Comment | Lysine is a metabolite of the lysine degradation and the aminoacyl tRNA biosynthesis. (cited information) |
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Formal Description Interaction-ID: 40662 |
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| Comment | Glutaric acid is a metabolite of the lysine degradation and the fatty acid metabolism. (cited information) |
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Formal Description Interaction-ID: 40663 |
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| Comment | Glutaric acid is a metabolite of the lysine degradation and the fatty acid metabolism. (cited information) |
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Formal Description Interaction-ID: 40664 |
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| Comment | Methionine is a metabolite of the methionine metabolism. (cited information) |
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Formal Description Interaction-ID: 40665 |
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| Comment | N1-Methylnicotinamide, N1-methylnicotinic acid, nicotinamide-n-oxide, N-methyl-2-pyridone-5-carboxamide, and N-methyl-4-pyridone-3-carboxamide are metabolites of the nicotinate and nicotinamide metabolism. (cited information) |
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Formal Description Interaction-ID: 40671 |
process nicotinate and nicotinamide metabolic process affects_quantity of drug/chemical compound |
| Comment | N1-Methylnicotinamide, N1-methylnicotinic acid, nicotinamide-n-oxide, N-methyl-2-pyridone-5-carboxamide, and N-methyl-4-pyridone-3-carboxamide are metabolites of the nicotinate and nicotinamide metabolism. (cited information) |
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Formal Description Interaction-ID: 40672 |
process nicotinate and nicotinamide metabolic process affects_quantity of drug/chemical compound |
| Comment | N1-Methylnicotinamide, N1-methylnicotinic acid, nicotinamide-n-oxide, N-methyl-2-pyridone-5-carboxamide, and N-methyl-4-pyridone-3-carboxamide are metabolites of the nicotinate and nicotinamide metabolism. (cited information) |
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Formal Description Interaction-ID: 40673 |
process nicotinate and nicotinamide metabolic process affects_quantity of drug/chemical compound Nicotinamide N-oxide |
| Comment | N1-Methylnicotinamide, N1-methylnicotinic acid, nicotinamide-n-oxide, N-methyl-2-pyridone-5-carboxamide, and N-methyl-4-pyridone-3-carboxamide are metabolites of the nicotinate and nicotinamide metabolism. (cited information) |
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Formal Description Interaction-ID: 40674 |
process nicotinate and nicotinamide metabolic process affects_quantity of drug/chemical compound |
| Comment | N1-Methylnicotinamide, N1-methylnicotinic acid, nicotinamide-n-oxide, N-methyl-2-pyridone-5-carboxamide, and N-methyl-4-pyridone-3-carboxamide are metabolites of the nicotinate and nicotinamide metabolism. (cited information) |
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Formal Description Interaction-ID: 40675 |
process nicotinate and nicotinamide metabolic process affects_quantity of drug/chemical compound |
| Comment | Pantothenate is a metabolite of the pantothenate and coA biosynthesis and the beta-alanine metabolism. (cited information) |
|
Formal Description Interaction-ID: 40677 |
process pantothenate and CoA biosynthetic process affects_quantity of drug/chemical compound |
| Comment | Pantothenate is a metabolite of the pantothenate and coA biosynthesis and the beta-alanine metabolism. (cited information) |
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Formal Description Interaction-ID: 40678 |
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| Comment | 3-Ureidopropanoate and allantoin are metabolites of the purine metabolism. (cited information) |
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Formal Description Interaction-ID: 40681 |
affects_quantity of drug/chemical compound |
| Comment | 3-Ureidopropanoate and allantoin are metabolites of the purine metabolism. (cited information) |
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Formal Description Interaction-ID: 40682 |
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| Comment | Orotate is a metabolite of the pyrimidine metabolism. (cited information) |
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Formal Description Interaction-ID: 40687 |
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| Comment | Sucrose is a metabolite of the starch and glucose metabolism. (cited information) |
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Formal Description Interaction-ID: 40688 |
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| Drugbank entries | Show/Hide entries for |
| Comment | Isocaproylglycine is a metabolite of the steroid hormone production. (cited information) |
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Formal Description Interaction-ID: 40689 |
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| Comment | Taurine is a metabolite of the taurine and hypotaurine metabolism. (cited information) |
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Formal Description Interaction-ID: 40690 |
process taurine and hypotaurine metabolic process affects_quantity of drug/chemical compound |
| Comment | (s)-Malate, 2-oxoglutarate, cis-aconitate, citrate, fumarate, and succinate are metabolites of the TCA cycle. (cited information) |
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Formal Description Interaction-ID: 40697 |
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| Comment | (s)-Malate, 2-oxoglutarate, cis-aconitate, citrate, fumarate, and succinate are metabolites of the TCA cycle. (cited information) |
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Formal Description Interaction-ID: 40698 |
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| Comment | (s)-Malate, 2-oxoglutarate, cis-aconitate, citrate, fumarate, and succinate are metabolites of the TCA cycle. (cited information) |
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Formal Description Interaction-ID: 40699 |
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| Comment | (s)-Malate, 2-oxoglutarate, cis-aconitate, citrate, fumarate, and succinate are metabolites of the TCA cycle. (cited information) |
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Formal Description Interaction-ID: 40700 |
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| Comment | (s)-Malate, 2-oxoglutarate, cis-aconitate, citrate, fumarate, and succinate are metabolites of the TCA cycle. (cited information) |
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Formal Description Interaction-ID: 40701 |
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| Drugbank entries | Show/Hide entries for |
| Comment | (s)-Malate, 2-oxoglutarate, cis-aconitate, citrate, fumarate, and succinate are metabolites of the TCA cycle. (cited information) |
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Formal Description Interaction-ID: 40702 |
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| Comment | Indoxyl sulfate is a metabolite of the tryptophan metabolism. (cited information) |
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Formal Description Interaction-ID: 40705 |
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| Comment | Tyrosine is a metabolite of the tyrosine metabolism. (cited information) |
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Formal Description Interaction-ID: 40706 |
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| Comment | Citrulline, L-argininosuccinic acid, N-acetyl citrulline, and ornithine are metabolites of the urea cycle. (cited information) |
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Formal Description Interaction-ID: 40711 |
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| Comment | Citrulline, L-argininosuccinic acid, N-acetyl citrulline, and ornithine are metabolites of the urea cycle. (cited information) |
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Formal Description Interaction-ID: 40712 |
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| Drugbank entries | Show/Hide entries for |
| Comment | Citrulline, L-argininosuccinic acid, N-acetyl citrulline, and ornithine are metabolites of the urea cycle. (cited information) |
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Formal Description Interaction-ID: 40713 |
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| Drugbank entries | Show/Hide entries for |
| Comment | Citrulline, L-argininosuccinic acid, N-acetyl citrulline, and ornithine are metabolites of the urea cycle. (cited information) |
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Formal Description Interaction-ID: 40714 |
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| Comment | 2-Hydroxy isobutyrate, 2-hydroxyisovalerate, 2-oxo-3-methyl-N-valerate, 2-oxoisocaproate, 2-oxoisovalerate, isobutyrylglycine, isovalerate, isovalerylglycine, methylmalonate, and valine are metabolites of the valine, leucine and isoleucine degradation. (cited information) |
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Formal Description Interaction-ID: 40725 |
affects_quantity of drug/chemical compound 2-Hydroxyisobutyric acid |
| Comment | 2-Hydroxy isobutyrate, 2-hydroxyisovalerate, 2-oxo-3-methyl-N-valerate, 2-oxoisocaproate, 2-oxoisovalerate, isobutyrylglycine, isovalerate, isovalerylglycine, methylmalonate, and valine are metabolites of the valine, leucine and isoleucine degradation. (cited information) |
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Formal Description Interaction-ID: 40726 |
affects_quantity of drug/chemical compound 2-Hydroxy-3-methylbutyric acid |
| Comment | 2-Hydroxy isobutyrate, 2-hydroxyisovalerate, 2-oxo-3-methyl-N-valerate, 2-oxoisocaproate, 2-oxoisovalerate, isobutyrylglycine, isovalerate, isovalerylglycine, methylmalonate, and valine are metabolites of the valine, leucine and isoleucine degradation. (cited information) |
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Formal Description Interaction-ID: 40727 |
affects_quantity of drug/chemical compound |
| Comment | 2-Hydroxy isobutyrate, 2-hydroxyisovalerate, 2-oxo-3-methyl-N-valerate, 2-oxoisocaproate, 2-oxoisovalerate, isobutyrylglycine, isovalerate, isovalerylglycine, methylmalonate, and valine are metabolites of the valine, leucine and isoleucine degradation. (cited information) |
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Formal Description Interaction-ID: 40728 |
affects_quantity of drug/chemical compound |
| Comment | 2-Hydroxy isobutyrate, 2-hydroxyisovalerate, 2-oxo-3-methyl-N-valerate, 2-oxoisocaproate, 2-oxoisovalerate, isobutyrylglycine, isovalerate, isovalerylglycine, methylmalonate, and valine are metabolites of the valine, leucine and isoleucine degradation. (cited information) |
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Formal Description Interaction-ID: 40729 |
affects_quantity of drug/chemical compound |
| Comment | 2-Hydroxy isobutyrate, 2-hydroxyisovalerate, 2-oxo-3-methyl-N-valerate, 2-oxoisocaproate, 2-oxoisovalerate, isobutyrylglycine, isovalerate, isovalerylglycine, methylmalonate, and valine are metabolites of the valine, leucine and isoleucine degradation. (cited information) |
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Formal Description Interaction-ID: 40730 |
affects_quantity of drug/chemical compound Isobutyrylglycine |
| Comment | 2-Hydroxy isobutyrate, 2-hydroxyisovalerate, 2-oxo-3-methyl-N-valerate, 2-oxoisocaproate, 2-oxoisovalerate, isobutyrylglycine, isovalerate, isovalerylglycine, methylmalonate, and valine are metabolites of the valine, leucine and isoleucine degradation. (cited information) |
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Formal Description Interaction-ID: 40731 |
affects_quantity of drug/chemical compound |
| Comment | 2-Hydroxy isobutyrate, 2-hydroxyisovalerate, 2-oxo-3-methyl-N-valerate, 2-oxoisocaproate, 2-oxoisovalerate, isobutyrylglycine, isovalerate, isovalerylglycine, methylmalonate, and valine are metabolites of the valine, leucine and isoleucine degradation. (cited information) |
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Formal Description Interaction-ID: 40732 |
affects_quantity of drug/chemical compound Isovalerylglycine |
| Comment | 2-Hydroxy isobutyrate, 2-hydroxyisovalerate, 2-oxo-3-methyl-N-valerate, 2-oxoisocaproate, 2-oxoisovalerate, isobutyrylglycine, isovalerate, isovalerylglycine, methylmalonate, and valine are metabolites of the valine, leucine and isoleucine degradation. (cited information) |
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Formal Description Interaction-ID: 40733 |
affects_quantity of drug/chemical compound |
| Comment | 2-Hydroxy isobutyrate, 2-hydroxyisovalerate, 2-oxo-3-methyl-N-valerate, 2-oxoisocaproate, 2-oxoisovalerate, isobutyrylglycine, isovalerate, isovalerylglycine, methylmalonate, and valine are metabolites of the valine, leucine and isoleucine degradation. (cited information) |
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Formal Description Interaction-ID: 40734 |
affects_quantity of drug/chemical compound |
| Comment | Dimethylamine, methylamine, and trimethyl amine are metabolites of gut microflora origin. They are metabolites of the bacterial methane metabolism. (cited information) |
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Formal Description Interaction-ID: 40744 |
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| Comment | Dimethylamine, methylamine, and trimethyl amine are metabolites of gut microflora origin. They are metabolites of the bacterial methane metabolism. (cited information) |
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Formal Description Interaction-ID: 40745 |
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| Drugbank entries | Show/Hide entries for |
| Comment | Dimethylamine, methylamine, and trimethyl amine are metabolites of gut microflora origin. They are metabolites of the bacterial methane metabolism. (cited information) |
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Formal Description Interaction-ID: 40746 |
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| Comment | p-Cresol is a metabolite of gut microflora origin. It is a metabolite of the bacterial toluene and xylene degradation. (cited information) |
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Formal Description Interaction-ID: 40747 |
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| Comment | m-Hydroxyphenyl propionic acid, m-hydroxyphenyl propionic acid sulfate, phenyl sulfate, and hippurate are metabolites of gut microflora origin. They are metabolites of the bacterial phenyl alanine metabolism. (cited information) |
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Formal Description Interaction-ID: 40748 |
environment gut flora affects_quantity of drug/chemical compound |
| Comment | m-Hydroxyphenyl propionic acid, m-hydroxyphenyl propionic acid sulfate, phenyl sulfate, and hippurate are metabolites of gut microflora origin. They are metabolites of the bacterial phenyl alanine metabolism. (cited information) |
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Formal Description Interaction-ID: 40749 |
environment gut flora affects_quantity of drug/chemical compound 3-Hydroxy-3-(3-hydroxyphenyl)propanoic acid-O-sulphate |
| Comment | m-Hydroxyphenyl propionic acid, m-hydroxyphenyl propionic acid sulfate, phenyl sulfate, and hippurate are metabolites of gut microflora origin. They are metabolites of the bacterial phenyl alanine metabolism. (cited information) |
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Formal Description Interaction-ID: 40750 |
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| Comment | m-Hydroxyphenyl propionic acid, m-hydroxyphenyl propionic acid sulfate, phenyl sulfate, and hippurate are metabolites of gut microflora origin. They are metabolites of the bacterial phenyl alanine metabolism. (cited information) |
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Formal Description Interaction-ID: 40751 |
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| Comment | (S)-Malate is a substrate of mitochondrial malate dehydrogenase (EC 1.1.1.37), an enzyme of the citrate cycle. (cited information) |
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Formal Description Interaction-ID: 40766 |
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| Drugbank entries | Show/Hide entries for MDH2 |
| Comment | (S)-Malate is a substrate of mitochondrial malate dehydrogenase (EC 1.1.1.37), an enzyme of the citrate cycle. (cited information) |
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Formal Description Interaction-ID: 40767 |
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| Drugbank entries | Show/Hide entries for MDH2 |
| Comment | Mitochondrial fumarate hydratase (EC 4.2.1.2), an enzyme of the citrate cycle, catalyzes the conversion of (S)-malate to fumarate and water. (cited information) |
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Formal Description Interaction-ID: 40769 |
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| Drugbank entries | Show/Hide entries for |
| Comment | Mitochondrial fumarate hydratase (EC 4.2.1.2), an enzyme of the citrate cycle, catalyzes the conversion of (S)-malate to fumarate and water. (cited information) |
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Formal Description Interaction-ID: 40770 |
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| Comment | Mitochondrial fumarate hydratase (EC 4.2.1.2), an enzyme of the citrate cycle, catalyzes the conversion of (S)-malate to fumarate and water. (cited information) |
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Formal Description Interaction-ID: 40771 |
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| Comment | Mitochondrial succinate dehydrogenase ubiquinone flavoprotein subunit (EC 1.3.99.1), an enzyme of the citrate cycle, catalyzes the conversion of fumarate to succinate. (cited information) |
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Formal Description Interaction-ID: 40773 |
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| Drugbank entries | Show/Hide entries for SDHA or Fumarate |
| Comment | Mitochondrial succinate dehydrogenase ubiquinone flavoprotein subunit (EC 1.3.99.1), an enzyme of the citrate cycle, catalyzes the conversion of fumarate to succinate. (cited information) |
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Formal Description Interaction-ID: 40774 |
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| Drugbank entries | Show/Hide entries for SDHA |
| Comment | Mitochondrial succinate dehydrogenase ubiquinone flavoprotein subunit (EC 1.3.99.1), an enzyme of the citrate cycle, catalyzes the conversion of fumarate to succinate. (cited information) |
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Formal Description Interaction-ID: 40775 |
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| Drugbank entries | Show/Hide entries for SDHA |
| Comment | Mitochondrial succinate dehydrogenase ubiquinone iron-sulfur subunit (EC 1.3.5.1), an enzyme of the citrate cycle, catalyzes the conversion of fumarate to succinate. (cited information) |
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Formal Description Interaction-ID: 40777 |
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| Drugbank entries | Show/Hide entries for SDHB |
| Comment | Mitochondrial succinate dehydrogenase ubiquinone iron-sulfur subunit (EC 1.3.5.1), an enzyme of the citrate cycle, catalyzes the conversion of fumarate to succinate. (cited information) |
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Formal Description Interaction-ID: 40778 |
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| Drugbank entries | Show/Hide entries for SDHB or Fumarate |
| Comment | Mitochondrial succinate dehydrogenase ubiquinone iron-sulfur subunit (EC 1.3.5.1), an enzyme of the citrate cycle, catalyzes the conversion of fumarate to succinate. (cited information) |
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Formal Description Interaction-ID: 40779 |
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| Drugbank entries | Show/Hide entries for SDHB |
| Comment | Mitochondrial ADP/GDP-forming succinyl-CoA ligase subunit alpha (EC 6.2.1.4, EC 6.2.1.5), an enzyme of the citrate cycle, catalyzes the ligation of succinate and CoA to form succinyl-CoA. (cited information) |
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Formal Description Interaction-ID: 40790 |
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| Drugbank entries | Show/Hide entries for SUCLG1 |
| Comment | Mitochondrial ADP-forming succinyl-CoA ligase subunit alpha (EC 6.2.1.4, EC 6.2.1.5), an enzyme of the citrate cycle, catalyzes the ligation of succinate and CoA to form succinyl-CoA. (cited information) |
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Formal Description Interaction-ID: 40791 |
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| Drugbank entries | Show/Hide entries for SUCLG2 |
| Comment | Mitochondrial ADP/GDP-forming succinyl-CoA ligase subunit alpha (EC 6.2.1.4, EC 6.2.1.5), an enzyme of the citrate cycle, catalyzes the ligation of succinate and CoA to form succinyl-CoA. (cited information) |
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Formal Description Interaction-ID: 40792 |
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| Drugbank entries | Show/Hide entries for SUCLG1 |
| Comment | Mitochondrial ADP/GDP-forming succinyl-CoA ligase subunit alpha (EC 6.2.1.4, EC 6.2.1.5), an enzyme of the citrate cycle, catalyzes the ligation of succinate and CoA to form succinyl-CoA. (cited information) |
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Formal Description Interaction-ID: 40793 |
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| Drugbank entries | Show/Hide entries for SUCLG2 |
| Comment | Mitochondrial dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex (EC 2.3.1.61), an enzyme of the citrate cycle, is a subunit of the 2-oxoglutarate dehydrogenase complex. The 2-oxoglutarate dehydrogenase complex catalyzyes the conversion of 2-oxoglutarate to succinyl-CoA and CO2. (cited information) |
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Formal Description Interaction-ID: 40795 |
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| Comment | Mitochondrial dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex (EC 2.3.1.61), an enzyme of the citrate cycle, is a subunit of the 2-oxoglutarate dehydrogenase complex. The 2-oxoglutarate dehydrogenase complex catalyzyes the conversion of 2-oxoglutarate to succinyl-CoA and CO2. (cited information) |
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Formal Description Interaction-ID: 40796 |
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| Comment | Mitochondrial dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex (EC 2.3.1.61), an enzyme of the citrate cycle, is a subunit of the 2-oxoglutarate dehydrogenase complex. The 2-oxoglutarate dehydrogenase complex catalyzyes the conversion of 2-oxoglutarate to succinyl-CoA and CO2. (cited information) |
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Formal Description Interaction-ID: 40797 |
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| Comment | Mitochondrial dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex (EC 2.3.1.61), an enzyme of the citrate cycle, is a subunit of the 2-oxoglutarate dehydrogenase complex. The 2-oxoglutarate dehydrogenase complex catalyzyes the conversion of 2-oxoglutarate to succinyl-CoA and CO2. (cited information) |
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Formal Description Interaction-ID: 40798 |
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| Comment | Mitochondrial dihydrolipoyl dehydrogenase (EC 1.8.1.4), an enzyme of the citrate cycle, catalyzes the conversion of dihydrolipoamide to lipoamide. (cited information) |
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Formal Description Interaction-ID: 40800 |
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| Drugbank entries | Show/Hide entries for DLD |
| Comment | Mitochondrial dihydrolipoyl dehydrogenase (EC 1.8.1.4), an enzyme of the citrate cycle, catalyzes the conversion of dihydrolipoamide to lipoamide. (cited information) |
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Formal Description Interaction-ID: 40801 |
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| Drugbank entries | Show/Hide entries for DLD |
| Comment | Mitochondrial aconitate hydratase (EC 4.2.1.3), an enzyme of the citrate cycle, catalyzes the isomerization of citrate to isocitrate via cis-aconitate. (cited information) |
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Formal Description Interaction-ID: 40803 |
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| Drugbank entries | Show/Hide entries for ACO2 |
| Comment | Mitochondrial aconitate hydratase (EC 4.2.1.3), an enzyme of the citrate cycle, catalyzes the isomerization of citrate to isocitrate via cis-aconitate. (cited information) |
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Formal Description Interaction-ID: 40804 |
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| Drugbank entries | Show/Hide entries for ACO2 |
| Comment | Mitochondrial aconitate hydratase (EC 4.2.1.3), an enzyme of the citrate cycle, catalyzes the isomerization of citrate to isocitrate via cis-aconitate. (cited information) |
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Formal Description Interaction-ID: 40805 |
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| Drugbank entries | Show/Hide entries for ACO2 |
| Comment | Mitochondrial citrate (pro-3S)-lyase (EC 4.1.3.6), an enzyme of the citrate cycle, catalyzes the conversion of citrate to acetate and oxaloacetate. (cited information) |
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Formal Description Interaction-ID: 40807 |
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| Comment | Mitochondrial citrate (pro-3S)-lyase (EC 4.1.3.6), an enzyme of the citrate cycle, catalyzes the conversion of citrate to acetate and oxaloacetate. (cited information) |
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Formal Description Interaction-ID: 40808 |
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| Comment | Mitochondrial citrate (pro-3S)-lyase (EC 4.1.3.6), an enzyme of the citrate cycle, catalyzes the conversion of citrate to acetate and oxaloacetate. (cited information) |
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Formal Description Interaction-ID: 40809 |
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| Comment | Mitochondrial citrate (pro-3S)-lyase (EC 4.1.3.6), an enzyme of the citrate cycle, catalyzes the conversion of citrate to acetate and oxaloacetate. (cited information) |
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Formal Description Interaction-ID: 40810 |
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| Comment | ATP-citrate synthase (EC 2.3.3.8), an enzyme of the citrate cycle, catalyzes the conversion of acetyl-CoA and oxalacetate to citrate. (cited information) |
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Formal Description Interaction-ID: 40813 |
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| Comment | ATP-citrate synthase (EC 2.3.3.8), an enzyme of the citrate cycle, catalyzes the conversion of acetyl-CoA and oxalacetate to citrate. (cited information) |
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Formal Description Interaction-ID: 40816 |
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| Comment | ATP-citrate synthase (EC 2.3.3.8), an enzyme of the citrate cycle, catalyzes the conversion of acetyl-CoA and oxalacetate to citrate. (cited information) |
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Formal Description Interaction-ID: 40817 |
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| Comment | ATP-citrate synthase (EC 2.3.3.8), an enzyme of the citrate cycle, catalyzes the conversion of acetyl-CoA and oxalacetate to citrate. (cited information) |
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Formal Description Interaction-ID: 40822 |
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| Comment | Mitochondrial citrate synthase (EC 2.3.3.1), an enzyme of the citrate cycle, catalyzes the conversion of acetyl-CoA and oxalacetate to citrate. (cited information) |
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Formal Description Interaction-ID: 40827 |
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| Drugbank entries | Show/Hide entries for CS |
| Comment | Mitochondrial citrate synthase (EC 2.3.3.1), an enzyme of the citrate cycle, catalyzes the conversion of acetyl-CoA and oxalacetate to citrate. (cited information) |
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Formal Description Interaction-ID: 40829 |
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| Drugbank entries | Show/Hide entries for CS |
| Comment | Mitochondrial citrate synthase (EC 2.3.3.1), an enzyme of the citrate cycle, catalyzes the conversion of acetyl-CoA and oxalacetate to citrate. (cited information) |
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Formal Description Interaction-ID: 40830 |
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| Drugbank entries | Show/Hide entries for CS |
| Comment | Mitochondrial citrate synthase (EC 2.3.3.1), an enzyme of the citrate cycle, catalyzes the conversion of acetyl-CoA and oxalacetate to citrate. (cited information) |
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Formal Description Interaction-ID: 40831 |
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| Drugbank entries | Show/Hide entries for CS |
| Comment | Mitochondrial pyruvate carboxylase (EC 6.4.1.1), an enzyme of the citrate cycle, catalyzes the conversion of pyruvate to oxaloacetate. (cited information) |
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Formal Description Interaction-ID: 40837 |
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| Drugbank entries | Show/Hide entries for PC |
| Comment | Mitochondrial pyruvate carboxylase (EC 6.4.1.1), an enzyme of the citrate cycle, catalyzes the conversion of pyruvate to oxaloacetate. (cited information) |
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Formal Description Interaction-ID: 40838 |
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| Drugbank entries | Show/Hide entries for PC |
| Comment | Mitochondrial pyruvate carboxylase (EC 6.4.1.1), an enzyme of the citrate cycle, catalyzes the conversion of pyruvate to oxaloacetate. (cited information) |
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Formal Description Interaction-ID: 40841 |
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| Drugbank entries | Show/Hide entries for PC |
| Comment | Mitochondrial 2-oxoglutarate dehydrogenase (EC 1.2.4.2) is a subunit of the 2-oxoglutarate dehydrogenase complex. The 2-oxoglutarate dehydrogenase complex catalyzyes the conversion of 2-oxoglutarate to succinyl-CoA and CO2. (cited information) |
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Formal Description Interaction-ID: 40845 |
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| Drugbank entries | Show/Hide entries for OGDH |
| Comment | IDH3A is a subunit of mitochondrial isocitrate dehydrogenase [NAD], an enzyme of the citrate cycle. Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. (cited information) |
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Formal Description Interaction-ID: 40847 |
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| Drugbank entries | Show/Hide entries for IDH3A |
| Comment | IDH3A is a subunit of mitochondrial isocitrate dehydrogenase [NAD], an enzyme of the citrate cycle. Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. (cited information) |
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Formal Description Interaction-ID: 40856 |
complex/PPI affects_activity of process |
| Comment | IDH3A is a subunit of mitochondrial isocitrate dehydrogenase [NAD], an enzyme of the citrate cycle. Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. (cited information) |
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Formal Description Interaction-ID: 40858 |
complex/PPI decreases_quantity of drug/chemical compound |
| Comment | IDH3A is a subunit of mitochondrial isocitrate dehydrogenase [NAD], an enzyme of the citrate cycle. Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. (cited information) |
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Formal Description Interaction-ID: 40859 |
complex/PPI increases_quantity of drug/chemical compound |
| Comment | Mitochondrial isocitrate dehydrogenase [NADP] (IDH2), an enzyme of the citrate cycle, catalyzes the conversion of isocitrate to 2-oxoglutarate. (cited information) |
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Formal Description Interaction-ID: 40861 |
complex/PPI affects_activity of process |
| Comment | Mitochondrial isocitrate dehydrogenase [NADP] (IDH2), an enzyme of the citrate cycle, catalyzes the conversion of isocitrate to 2-oxoglutarate. (cited information) |
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Formal Description Interaction-ID: 40862 |
complex/PPI decreases_quantity of drug/chemical compound |
| Comment | Mitochondrial isocitrate dehydrogenase [NADP] (IDH2), an enzyme of the citrate cycle, catalyzes the conversion of isocitrate to 2-oxoglutarate. (cited information) |
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Formal Description Interaction-ID: 40863 |
complex/PPI increases_quantity of drug/chemical compound |
| Comment | Cytosolic phosphoenolpyruvate carboxykinase [GTP] (EC 4.1.1.32) catalyzes the conversion of oxaloacetate to phosphoenolpyruvate, the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. (cited information) |
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Formal Description Interaction-ID: 40869 |
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| Drugbank entries | Show/Hide entries for PCK1 |
| Comment | Cytosolic phosphoenolpyruvate carboxykinase [GTP] (EC 4.1.1.32) catalyzes the conversion of oxaloacetate to phosphoenolpyruvate, the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. (cited information) |
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Formal Description Interaction-ID: 40870 |
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| Drugbank entries | Show/Hide entries for PCK1 or Phosphoenolpyruvate |
| Comment | Mitochondrial acetyl-CoA synthetase (EC 6.2.1.1) catalyzes the conversion of acetate to acetyl CoA. (cited information) |
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Formal Description Interaction-ID: 40901 |
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| Drugbank entries | Show/Hide entries for ACSS1 |
| Comment | Mitochondrial acetyl-CoA synthetase (EC 6.2.1.1) catalyzes the conversion of acetate to acetyl CoA. (cited information) |
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Formal Description Interaction-ID: 40903 |
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| Drugbank entries | Show/Hide entries for ACSS1 |
| Comment | Glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12), an enzyme involved in gluconeogenesis, catalyzes the oxidative phosphorylation of glyceraldehyde-3-phosphate. (cited information) |
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Formal Description Interaction-ID: 40905 |
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| Drugbank entries | Show/Hide entries for GAPDH |
| Comment | Glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12), an enzyme involved in gluconeogenesis, catalyzes the oxidative phosphorylation of glyceraldehyde-3-phosphate. (cited information) |
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Formal Description Interaction-ID: 40906 |
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| Drugbank entries | Show/Hide entries for GAPDH |
| Comment | The gluconeogenetic enzyme fructose-bisphosphate aldolase B (EC 4.1.2.13) catalyzes the conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. (cited information) |
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Formal Description Interaction-ID: 40908 |
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| Drugbank entries | Show/Hide entries for ALDOB |
| Comment | The gluconeogenetic enzyme fructose-bisphosphate aldolase B (EC 4.1.2.13) catalyzes the conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. (cited information) |
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Formal Description Interaction-ID: 40909 |
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| Drugbank entries | Show/Hide entries for ALDOB |
| Comment | The gluconeogenetic enzyme fructose-bisphosphate aldolase B (EC 4.1.2.13) catalyzes the conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. (cited information) |
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Formal Description Interaction-ID: 40910 |
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| Drugbank entries | Show/Hide entries for ALDOB |
| Comment | The gluconeogenetic enzyme fructose-bisphosphate aldolase B (EC 4.1.2.13) catalyzes the conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. (cited information) |
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Formal Description Interaction-ID: 40911 |
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| Drugbank entries | Show/Hide entries for ALDOB |
| Comment | The thermodynamically irreversible reactions that are unique to liver (and kidney) gluconeogenesis (pyruvate carboxylase PC, phosphoenolpyruvate carboxykinase PCK1, fructose 1,6-bisphosphatase FBP1, and glucose 6-phosphatase G6PC) are all up-regulated in the liver of diabetic db/db mice. (cited information) |
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Formal Description Interaction-ID: 40914 |
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| Drugbank entries | Show/Hide entries for PC |
| Comment | The thermodynamically irreversible reactions that are unique to liver (and kidney) gluconeogenesis (pyruvate carboxylase PC, phosphoenolpyruvate carboxykinase PCK1, fructose 1,6-bisphosphatase FBP1, and glucose 6-phosphatase G6PC) are all up-regulated in the liver of diabetic db/db mice. (cited information) |
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Formal Description Interaction-ID: 40915 |
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| Drugbank entries | Show/Hide entries for PCK1 |
| Comment | The thermodynamically irreversible reactions that are unique to liver (and kidney) gluconeogenesis (pyruvate carboxylase PC, phosphoenolpyruvate carboxykinase PCK1, fructose 1,6-bisphosphatase FBP1, and glucose 6-phosphatase G6PC) are all up-regulated in the liver of diabetic db/db mice. (cited information) |
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Formal Description Interaction-ID: 40916 |
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| Drugbank entries | Show/Hide entries for FBP1 |
| Comment | The thermodynamically irreversible reactions that are unique to liver (and kidney) gluconeogenesis (pyruvate carboxylase PC, phosphoenolpyruvate carboxykinase PCK1, fructose 1,6-bisphosphatase FBP1, and glucose 6-phosphatase G6PC) are all up-regulated in the liver of diabetic db/db mice. (cited information) |
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Formal Description Interaction-ID: 40917 |
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| Comment | The branched-chain alpha-keto dehydrogenase complex catalyzes the conversion of alpha-keto acids to acyl-CoA and CO2. It consists of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2, DBT) and lipoamide dehydrogenase (E3, DLD). The E1 component is a heterotetramer of two alpha chains (BCKDHA) and two beta chains (BCKDHB). BCAAs (valine, leucine and isoleucine) are degraded in muscle and adipose rather than liver. (cited information) |
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Formal Description Interaction-ID: 40943 |
complex/PPI Branched-chain keto acid dehydrogenase complex affects_activity of |