CIDeRplusGeneral Information:
| Id: | 3,991 |
| Diseases: |
Diabetes mellitus, type II
- [OMIM]
Insulin resistance |
| Mus musculus | |
| male | |
| db/db diabetic mouse | |
| article | |
| Reference: | Connor SC et al.(2010) Integration of metabolomics and transcriptomics data to aid biomarker discovery in type 2 diabetes Mol Biosyst 6: 909-921 [PMID: 20567778] |
Interaction Information:
| Comment | Sixty-six metabolites were identified in urine that discriminate between the diabetic db/db and control db/+ mice. |
|
Formal Description Interaction-ID: 40598 |
disease decreases_quantity of drug/chemical compound |
| Comment | Sixty-six metabolites were identified in urine that discriminate between the diabetic db/db and control db/+ mice. |
|
Formal Description Interaction-ID: 40599 |
disease increases_quantity of drug/chemical compound |
| Comment | Sixty-six metabolites were identified in urine that discriminate between the diabetic db/db and control db/+ mice. |
|
Formal Description Interaction-ID: 40614 |
disease increases_quantity of drug/chemical compound |
| Comment | Sixty-six metabolites were identified in urine that discriminate between the diabetic db/db and control db/+ mice. |
|
Formal Description Interaction-ID: 40615 |
disease increases_quantity of drug/chemical compound |
| Comment | Sixty-six metabolites were identified in urine that discriminate between the diabetic db/db and control db/+ mice. |
|
Formal Description Interaction-ID: 40616 |
disease increases_quantity of drug/chemical compound |
| Drugbank entries | Show/Hide entries for |
| Comment | Sixty-six metabolites were identified in urine that discriminate between the diabetic db/db and control db/+ mice. |
|
Formal Description Interaction-ID: 40617 |
disease increases_quantity of drug/chemical compound |
| Comment | Sixty-six metabolites were identified in urine that discriminate between the diabetic db/db and control db/+ mice. |
|
Formal Description Interaction-ID: 40626 |
disease decreases_quantity of drug/chemical compound Butyrylglycine |
| Comment | Sixty-six metabolites were identified in urine that discriminate between the diabetic db/db and control db/+ mice. |
|
Formal Description Interaction-ID: 40627 |
disease increases_quantity of drug/chemical compound |
| Comment | Sixty-six metabolites were identified in urine that discriminate between the diabetic db/db and control db/+ mice. |
|
Formal Description Interaction-ID: 40628 |
disease increases_quantity of drug/chemical compound |
| Comment | Sixty-six metabolites were identified in urine that discriminate between the diabetic db/db and control db/+ mice. |
|
Formal Description Interaction-ID: 40629 |
disease decreases_quantity of drug/chemical compound 2-Hydroxyvaleric acid |
| Comment | Sixty-six metabolites were identified in urine that discriminate between the diabetic db/db and control db/+ mice. |
|
Formal Description Interaction-ID: 40630 |
disease decreases_quantity of drug/chemical compound Hexanoylglycine |
| Comment | Sixty-six metabolites were identified in urine that discriminate between the diabetic db/db and control db/+ mice. |
|
Formal Description Interaction-ID: 40636 |
disease increases_quantity of drug/chemical compound |
| Drugbank entries | Show/Hide entries for |
| Comment | Sixty-six metabolites were identified in urine that discriminate between the diabetic db/db and control db/+ mice. |
|
Formal Description Interaction-ID: 40638 |
disease increases_quantity of drug/chemical compound |
| Drugbank entries | Show/Hide entries for |
| Comment | Sixty-six metabolites were identified in urine that discriminate between the diabetic db/db and control db/+ mice. |
|
Formal Description Interaction-ID: 40639 |
disease increases_quantity of drug/chemical compound |
| Comment | Sixty-six metabolites were identified in urine that discriminate between the diabetic db/db and control db/+ mice. |
|
Formal Description Interaction-ID: 40640 |
disease decreases_quantity of drug/chemical compound Valerylglycine |
| Comment | Sixty-six metabolites were identified in urine that discriminate between the diabetic db/db and control db/+ mice. |
|
Formal Description Interaction-ID: 40644 |
disease increases_quantity of drug/chemical compound |
| Comment | Sixty-six metabolites were identified in urine that discriminate between the diabetic db/db and control db/+ mice. |
|
Formal Description Interaction-ID: 40645 |
disease increases_quantity of drug/chemical compound |
| Comment | Sixty-six metabolites were identified in urine that discriminate between the diabetic db/db and control db/+ mice. |
|
Formal Description Interaction-ID: 40648 |
disease increases_quantity of drug/chemical compound |
| Comment | Sixty-six metabolites were identified in urine that discriminate between the diabetic db/db and control db/+ mice. |
|
Formal Description Interaction-ID: 40649 |
disease increases_quantity of drug/chemical compound |
| Comment | Sixty-six metabolites were identified in urine that discriminate between the diabetic db/db and control db/+ mice. |
|
Formal Description Interaction-ID: 40650 |
disease increases_quantity of drug/chemical compound |
| Comment | Sixty-six metabolites were identified in urine that discriminate between the diabetic db/db and control db/+ mice. |
|
Formal Description Interaction-ID: 40656 |
disease increases_quantity of drug/chemical compound |
| Comment | Sixty-six metabolites were identified in urine that discriminate between the diabetic db/db and control db/+ mice. |
|
Formal Description Interaction-ID: 40657 |
disease increases_quantity of drug/chemical compound |
| Comment | Sixty-six metabolites were identified in urine that discriminate between the diabetic db/db and control db/+ mice. |
|
Formal Description Interaction-ID: 40658 |
disease decreases_quantity of drug/chemical compound |
| Comment | Sixty-six metabolites were identified in urine that discriminate between the diabetic db/db and control db/+ mice. |
|
Formal Description Interaction-ID: 40659 |
disease increases_quantity of drug/chemical compound |
| Comment | Sixty-six metabolites were identified in urine that discriminate between the diabetic db/db and control db/+ mice. |
|
Formal Description Interaction-ID: 40666 |
disease increases_quantity of drug/chemical compound |
| Comment | Sixty-six metabolites were identified in urine that discriminate between the diabetic db/db and control db/+ mice. |
|
Formal Description Interaction-ID: 40667 |
disease increases_quantity of drug/chemical compound |
| Comment | Sixty-six metabolites were identified in urine that discriminate between the diabetic db/db and control db/+ mice. |
|
Formal Description Interaction-ID: 40668 |
disease increases_quantity of drug/chemical compound Nicotinamide N-oxide |
| Comment | Sixty-six metabolites were identified in urine that discriminate between the diabetic db/db and control db/+ mice. |
|
Formal Description Interaction-ID: 40669 |
disease increases_quantity of drug/chemical compound |
| Comment | Sixty-six metabolites were identified in urine that discriminate between the diabetic db/db and control db/+ mice. |
|
Formal Description Interaction-ID: 40670 |
disease increases_quantity of drug/chemical compound |
| Comment | Sixty-six metabolites were identified in urine that discriminate between the diabetic db/db and control db/+ mice. |
|
Formal Description Interaction-ID: 40676 |
disease increases_quantity of drug/chemical compound |
| Comment | Sixty-six metabolites were identified in urine that discriminate between the diabetic db/db and control db/+ mice. |
|
Formal Description Interaction-ID: 40679 |
disease increases_quantity of drug/chemical compound |
| Comment | Sixty-six metabolites were identified in urine that discriminate between the diabetic db/db and control db/+ mice. |
|
Formal Description Interaction-ID: 40680 |
disease increases_quantity of drug/chemical compound |
| Comment | Sixty-six metabolites were identified in urine that discriminate between the diabetic db/db and control db/+ mice. |
|
Formal Description Interaction-ID: 40683 |
disease increases_quantity of drug/chemical compound |
| Comment | Sixty-six metabolites were identified in urine that discriminate between the diabetic db/db and control db/+ mice. |
|
Formal Description Interaction-ID: 40684 |
disease increases_quantity of drug/chemical compound |
| Drugbank entries | Show/Hide entries for |
| Comment | Sixty-six metabolites were identified in urine that discriminate between the diabetic db/db and control db/+ mice. |
|
Formal Description Interaction-ID: 40685 |
disease decreases_quantity of drug/chemical compound Isocaproylglycine |
| Comment | Sixty-six metabolites were identified in urine that discriminate between the diabetic db/db and control db/+ mice. |
|
Formal Description Interaction-ID: 40686 |
disease decreases_quantity of drug/chemical compound |
| Comment | Sixty-six metabolites were identified in urine that discriminate between the diabetic db/db and control db/+ mice. |
|
Formal Description Interaction-ID: 40691 |
disease increases_quantity of drug/chemical compound |
| Comment | Sixty-six metabolites were identified in urine that discriminate between the diabetic db/db and control db/+ mice. |
|
Formal Description Interaction-ID: 40692 |
disease increases_quantity of drug/chemical compound |
| Comment | Sixty-six metabolites were identified in urine that discriminate between the diabetic db/db and control db/+ mice. |
|
Formal Description Interaction-ID: 40693 |
disease decreases_quantity of drug/chemical compound |
| Comment | Sixty-six metabolites were identified in urine that discriminate between the diabetic db/db and control db/+ mice. |
|
Formal Description Interaction-ID: 40694 |
disease increases_quantity of drug/chemical compound |
| Comment | Sixty-six metabolites were identified in urine that discriminate between the diabetic db/db and control db/+ mice. |
|
Formal Description Interaction-ID: 40695 |
disease increases_quantity of drug/chemical compound |
| Drugbank entries | Show/Hide entries for |
| Comment | Sixty-six metabolites were identified in urine that discriminate between the diabetic db/db and control db/+ mice. |
|
Formal Description Interaction-ID: 40696 |
disease increases_quantity of drug/chemical compound |
| Comment | Sixty-six metabolites were identified in urine that discriminate between the diabetic db/db and control db/+ mice. |
|
Formal Description Interaction-ID: 40703 |
disease decreases_quantity of drug/chemical compound Indoxyl sulfate |
| Comment | Sixty-six metabolites were identified in urine that discriminate between the diabetic db/db and control db/+ mice. |
|
Formal Description Interaction-ID: 40704 |
disease increases_quantity of drug/chemical compound |
| Comment | Sixty-six metabolites were identified in urine that discriminate between the diabetic db/db and control db/+ mice. |
|
Formal Description Interaction-ID: 40707 |
disease increases_quantity of drug/chemical compound |
| Comment | Sixty-six metabolites were identified in urine that discriminate between the diabetic db/db and control db/+ mice. |
|
Formal Description Interaction-ID: 40708 |
disease increases_quantity of drug/chemical compound |
| Drugbank entries | Show/Hide entries for |
| Comment | Sixty-six metabolites were identified in urine that discriminate between the diabetic db/db and control db/+ mice. |
|
Formal Description Interaction-ID: 40709 |
disease increases_quantity of drug/chemical compound |
| Drugbank entries | Show/Hide entries for |
| Comment | Sixty-six metabolites were identified in urine that discriminate between the diabetic db/db and control db/+ mice. |
|
Formal Description Interaction-ID: 40710 |
disease increases_quantity of drug/chemical compound |
| Comment | Sixty-six metabolites were identified in urine that discriminate between the diabetic db/db and control db/+ mice. |
|
Formal Description Interaction-ID: 40715 |
disease increases_quantity of drug/chemical compound 2-Hydroxyisobutyric acid |
| Comment | Sixty-six metabolites were identified in urine that discriminate between the diabetic db/db and control db/+ mice. |
|
Formal Description Interaction-ID: 40716 |
disease increases_quantity of drug/chemical compound 2-Hydroxy-3-methylbutyric acid |
| Comment | Sixty-six metabolites were identified in urine that discriminate between the diabetic db/db and control db/+ mice. |
|
Formal Description Interaction-ID: 40717 |
disease decreases_quantity of drug/chemical compound |
| Comment | Sixty-six metabolites were identified in urine that discriminate between the diabetic db/db and control db/+ mice. |
|
Formal Description Interaction-ID: 40718 |
disease decreases_quantity of drug/chemical compound |
| Comment | Sixty-six metabolites were identified in urine that discriminate between the diabetic db/db and control db/+ mice. |
|
Formal Description Interaction-ID: 40719 |
disease decreases_quantity of drug/chemical compound |
| Comment | Sixty-six metabolites were identified in urine that discriminate between the diabetic db/db and control db/+ mice. |
|
Formal Description Interaction-ID: 40720 |
disease decreases_quantity of drug/chemical compound Isobutyrylglycine |
| Comment | Sixty-six metabolites were identified in urine that discriminate between the diabetic db/db and control db/+ mice. |
|
Formal Description Interaction-ID: 40721 |
disease decreases_quantity of drug/chemical compound |
| Comment | Sixty-six metabolites were identified in urine that discriminate between the diabetic db/db and control db/+ mice. |
|
Formal Description Interaction-ID: 40722 |
disease decreases_quantity of drug/chemical compound Isovalerylglycine |
| Comment | Sixty-six metabolites were identified in urine that discriminate between the diabetic db/db and control db/+ mice. |
|
Formal Description Interaction-ID: 40723 |
disease decreases_quantity of drug/chemical compound |
| Comment | Sixty-six metabolites were identified in urine that discriminate between the diabetic db/db and control db/+ mice. |
|
Formal Description Interaction-ID: 40724 |
disease increases_quantity of drug/chemical compound |
| Comment | Sixty-six metabolites were identified in urine that discriminate between the diabetic db/db and control db/+ mice, including several that were previously confirmed as arising from gut microflora. |
|
Formal Description Interaction-ID: 40735 |
disease increases_quantity of drug/chemical compound |
| Comment | Sixty-six metabolites were identified in urine that discriminate between the diabetic db/db and control db/+ mice, including several that were previously confirmed as arising from gut microflora. |
|
Formal Description Interaction-ID: 40737 |
disease decreases_quantity of drug/chemical compound |
| Drugbank entries | Show/Hide entries for |
| Comment | Sixty-six metabolites were identified in urine that discriminate between the diabetic db/db and control db/+ mice, including several that were previously confirmed as arising from gut microflora. |
|
Formal Description Interaction-ID: 40738 |
disease decreases_quantity of drug/chemical compound |
| Comment | Sixty-six metabolites were identified in urine that discriminate between the diabetic db/db and control db/+ mice, including several that were previously confirmed as arising from gut microflora. |
|
Formal Description Interaction-ID: 40739 |
disease increases_quantity of drug/chemical compound |
| Comment | Sixty-six metabolites were identified in urine that discriminate between the diabetic db/db and control db/+ mice, including several that were previously confirmed as arising from gut microflora. |
|
Formal Description Interaction-ID: 40740 |
disease increases_quantity of drug/chemical compound |
| Comment | Sixty-six metabolites were identified in urine that discriminate between the diabetic db/db and control db/+ mice, including several that were previously confirmed as arising from gut microflora. |
|
Formal Description Interaction-ID: 40741 |
disease increases_quantity of drug/chemical compound 3-Hydroxy-3-(3-hydroxyphenyl)propanoic acid-O-sulphate |
| Comment | Sixty-six metabolites were identified in urine that discriminate between the diabetic db/db and control db/+ mice, including several that were previously confirmed as arising from gut microflora. |
|
Formal Description Interaction-ID: 40742 |
disease decreases_quantity of drug/chemical compound |
| Comment | Sixty-six metabolites were identified in urine that discriminate between the diabetic db/db and control db/+ mice, including several that were previously confirmed as arising from gut microflora. |
|
Formal Description Interaction-ID: 40743 |
disease decreases_quantity of drug/chemical compound |
| Comment | LEP, LPL, CD36 and CPT1A were all up-regulated in adipose tissue of db/db mice compared to db/+ mice, whilst GPAM, UCP3, AMPK and GLUT-4 were all down-regulated. |
|
Formal Description Interaction-ID: 40753 |
disease increases_expression of gene/protein |
| Comment | LEP, LPL, CD36 and CPT1A were all up-regulated in adipose tissue of db/db mice compared to db/+ mice, whilst GPAM, UCP3, AMPK and GLUT-4 were all down-regulated. |
|
Formal Description Interaction-ID: 40755 |
disease increases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for LPL |
| Comment | LEP, LPL, CD36 and CPT1A were all up-regulated in adipose tissue of db/db mice compared to db/+ mice, whilst GPAM, UCP3, AMPK and GLUT-4 were all down-regulated. |
|
Formal Description Interaction-ID: 40756 |
disease increases_expression of gene/protein |
| Comment | LEP, LPL, CD36 and CPT1A were all up-regulated in adipose tissue of db/db mice compared to db/+ mice, whilst GPAM, UCP3, AMPK and GLUT-4 were all down-regulated. |
|
Formal Description Interaction-ID: 40757 |
disease increases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for CPT1A |
| Comment | LEP, LPL, CD36 and CPT1A were all up-regulated in adipose tissue of db/db mice compared to db/+ mice, whilst GPAM, UCP3, AMPK and GLUT-4 were all down-regulated. |
|
Formal Description Interaction-ID: 40758 |
disease decreases_expression of gene/protein |
| Comment | LEP, LPL, CD36 and CPT1A were all up-regulated in adipose tissue of db/db mice compared to db/+ mice, whilst GPAM, UCP3, AMPK and GLUT-4 were all down-regulated. |
|
Formal Description Interaction-ID: 40759 |
disease decreases_expression of gene/protein |
| Comment | LEP, LPL, CD36 and CPT1A were all up-regulated in adipose tissue of db/db mice compared to db/+ mice, whilst GPAM, UCP3, AMPK and GLUT-4 were all down-regulated. |
|
Formal Description Interaction-ID: 40763 |
disease decreases_quantity of complex/PPI AMPK |
| Comment | LEP, LPL, CD36 and CPT1A were all up-regulated in adipose tissue of db/db mice compared to db/+ mice, whilst GPAM, UCP3, AMPK and GLUT-4 were all down-regulated. |
|
Formal Description Interaction-ID: 40764 |
disease decreases_expression of gene/protein |
| Comment | In liver several enzymes of the citrate cycle were up-regulated in db/db mice: EC 1.1.1.37, EC 4.2.1.2, EC 1.3.99.1, EC 1.3.5.1, EC 6.2.1.4, EC 6.2.1.5, EC 2.3.1.61, EC 1.8.1.4, EC 4.2.1.3, EC 4.1.3.6, EC 2.3.3.8, EC 2.3.3.1, and EC 6.4.1.1. EC 1.2.4.2 and IDH3A were down-regulated. |
|
Formal Description Interaction-ID: 40765 |
disease increases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for MDH2 |
| Comment | In liver several enzymes of the citrate cycle were up-regulated in db/db mice: EC 1.1.1.37, EC 4.2.1.2, EC 1.3.99.1, EC 1.3.5.1, EC 6.2.1.4, EC 6.2.1.5, EC 2.3.1.61, EC 1.8.1.4, EC 4.2.1.3, EC 4.1.3.6, EC 2.3.3.8, EC 2.3.3.1, and EC 6.4.1.1. EC 1.2.4.2 and IDH3A were down-regulated. |
|
Formal Description Interaction-ID: 40768 |
disease increases_expression of gene/protein |
| Comment | In liver several enzymes of the citrate cycle were up-regulated in db/db mice: EC 1.1.1.37, EC 4.2.1.2, EC 1.3.99.1, EC 1.3.5.1, EC 6.2.1.4, EC 6.2.1.5, EC 2.3.1.61, EC 1.8.1.4, EC 4.2.1.3, EC 4.1.3.6, EC 2.3.3.8, EC 2.3.3.1, and EC 6.4.1.1. EC 1.2.4.2 and IDH3A were down-regulated. |
|
Formal Description Interaction-ID: 40772 |
disease increases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for SDHA |
| Comment | In liver several enzymes of the citrate cycle were up-regulated in db/db mice: EC 1.1.1.37, EC 4.2.1.2, EC 1.3.99.1, EC 1.3.5.1, EC 6.2.1.4, EC 6.2.1.5, EC 2.3.1.61, EC 1.8.1.4, EC 4.2.1.3, EC 4.1.3.6, EC 2.3.3.8, EC 2.3.3.1, and EC 6.4.1.1. EC 1.2.4.2 and IDH3A were down-regulated. |
|
Formal Description Interaction-ID: 40776 |
disease increases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for SDHB |
| Comment | In liver several enzymes of the citrate cycle were up-regulated in db/db mice: EC 1.1.1.37, EC 4.2.1.2, EC 1.3.99.1, EC 1.3.5.1, EC 6.2.1.4, EC 6.2.1.5, EC 2.3.1.61, EC 1.8.1.4, EC 4.2.1.3, EC 4.1.3.6, EC 2.3.3.8, EC 2.3.3.1, and EC 6.4.1.1. EC 1.2.4.2 and IDH3A were down-regulated. |
|
Formal Description Interaction-ID: 40788 |
disease increases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for SUCLG1 |
| Comment | In liver several enzymes of the citrate cycle were up-regulated in db/db mice: EC 1.1.1.37, EC 4.2.1.2, EC 1.3.99.1, EC 1.3.5.1, EC 6.2.1.4, EC 6.2.1.5, EC 2.3.1.61, EC 1.8.1.4, EC 4.2.1.3, EC 4.1.3.6, EC 2.3.3.8, EC 2.3.3.1, and EC 6.4.1.1. EC 1.2.4.2 and IDH3A were down-regulated. |
|
Formal Description Interaction-ID: 40789 |
disease increases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for SUCLG2 |
| Comment | In liver several enzymes of the citrate cycle were up-regulated in db/db mice: EC 1.1.1.37, EC 4.2.1.2, EC 1.3.99.1, EC 1.3.5.1, EC 6.2.1.4, EC 6.2.1.5, EC 2.3.1.61, EC 1.8.1.4, EC 4.2.1.3, EC 4.1.3.6, EC 2.3.3.8, EC 2.3.3.1, and EC 6.4.1.1. EC 1.2.4.2 and IDH3A were down-regulated. |
|
Formal Description Interaction-ID: 40794 |
disease increases_expression of gene/protein |
| Comment | In liver several enzymes of the citrate cycle were up-regulated in db/db mice: EC 1.1.1.37, EC 4.2.1.2, EC 1.3.99.1, EC 1.3.5.1, EC 6.2.1.4, EC 6.2.1.5, EC 2.3.1.61, EC 1.8.1.4, EC 4.2.1.3, EC 4.1.3.6, EC 2.3.3.8, EC 2.3.3.1, and EC 6.4.1.1. EC 1.2.4.2 and IDH3A were down-regulated. |
|
Formal Description Interaction-ID: 40799 |
disease increases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for DLD |
| Comment | In liver several enzymes of the citrate cycle were up-regulated in db/db mice: EC 1.1.1.37, EC 4.2.1.2, EC 1.3.99.1, EC 1.3.5.1, EC 6.2.1.4, EC 6.2.1.5, EC 2.3.1.61, EC 1.8.1.4, EC 4.2.1.3, EC 4.1.3.6, EC 2.3.3.8, EC 2.3.3.1, and EC 6.4.1.1. EC 1.2.4.2 and IDH3A were down-regulated. |
|
Formal Description Interaction-ID: 40802 |
disease increases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for ACO2 |
| Comment | In liver several enzymes of the citrate cycle were up-regulated in db/db mice: EC 1.1.1.37, EC 4.2.1.2, EC 1.3.99.1, EC 1.3.5.1, EC 6.2.1.4, EC 6.2.1.5, EC 2.3.1.61, EC 1.8.1.4, EC 4.2.1.3, EC 4.1.3.6, EC 2.3.3.8, EC 2.3.3.1, and EC 6.4.1.1. EC 1.2.4.2 and IDH3A were down-regulated. |
|
Formal Description Interaction-ID: 40806 |
disease increases_expression of gene/protein |
| Comment | In liver several enzymes of the citrate cycle were up-regulated in db/db mice: EC 1.1.1.37, EC 4.2.1.2, EC 1.3.99.1, EC 1.3.5.1, EC 6.2.1.4, EC 6.2.1.5, EC 2.3.1.61, EC 1.8.1.4, EC 4.2.1.3, EC 4.1.3.6, EC 2.3.3.8, EC 2.3.3.1, and EC 6.4.1.1. EC 1.2.4.2 and IDH3A were down-regulated. |
|
Formal Description Interaction-ID: 40812 |
disease increases_expression of gene/protein |
| Comment | In liver several enzymes of the citrate cycle were up-regulated in db/db mice: EC 1.1.1.37, EC 4.2.1.2, EC 1.3.99.1, EC 1.3.5.1, EC 6.2.1.4, EC 6.2.1.5, EC 2.3.1.61, EC 1.8.1.4, EC 4.2.1.3, EC 4.1.3.6, EC 2.3.3.8, EC 2.3.3.1, and EC 6.4.1.1. EC 1.2.4.2 and IDH3A were down-regulated. |
|
Formal Description Interaction-ID: 40823 |
disease increases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for CS |
| Comment | In liver several enzymes of the citrate cycle were up-regulated in db/db mice: EC 1.1.1.37, EC 4.2.1.2, EC 1.3.99.1, EC 1.3.5.1, EC 6.2.1.4, EC 6.2.1.5, EC 2.3.1.61, EC 1.8.1.4, EC 4.2.1.3, EC 4.1.3.6, EC 2.3.3.8, EC 2.3.3.1, and EC 6.4.1.1. EC 1.2.4.2 and IDH3A were down-regulated. |
|
Formal Description Interaction-ID: 40834 |
disease increases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for PC |
| Comment | In liver several enzymes of the citrate cycle were up-regulated in db/db mice: EC 1.1.1.37, EC 4.2.1.2, EC 1.3.99.1, EC 1.3.5.1, EC 6.2.1.4, EC 6.2.1.5, EC 2.3.1.61, EC 1.8.1.4, EC 4.2.1.3, EC 4.1.3.6, EC 2.3.3.8, EC 2.3.3.1, and EC 6.4.1.1. EC 1.2.4.2 and IDH3A were down-regulated. |
|
Formal Description Interaction-ID: 40842 |
disease decreases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for OGDH |
| Comment | In liver several enzymes of the citrate cycle were up-regulated in db/db mice: EC 1.1.1.37, EC 4.2.1.2, EC 1.3.99.1, EC 1.3.5.1, EC 6.2.1.4, EC 6.2.1.5, EC 2.3.1.61, EC 1.8.1.4, EC 4.2.1.3, EC 4.1.3.6, EC 2.3.3.8, EC 2.3.3.1, and EC 6.4.1.1. EC 1.2.4.2 and IDH3A were down-regulated. |
|
Formal Description Interaction-ID: 40846 |
disease decreases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for IDH3A |
| Comment | In liver of db/db mice the expression of IDH2 is up-regulated. |
|
Formal Description Interaction-ID: 40860 |
disease increases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for IDH2 |
| Comment | In adipose tissue and muscles of db/db mice the expression of EC 6.4.1.1 is down-regulated. |
|
Formal Description Interaction-ID: 40866 |
disease decreases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for PC |
| Comment | In adipose tissue of db/db mice the expression of EC 4.1.1.32 is down-regulated. |
|
Formal Description Interaction-ID: 40867 |
disease decreases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for PCK1 |
| Comment | In muscles of db/db mice the expression of EC 1.1.1.37 is down-regulated. |
|
Formal Description Interaction-ID: 40871 |
disease decreases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for MDH2 |
| Comment | In adipose tissue of db/db mice the expression of EC 4.2.1.2 is down-regulated. |
|
Formal Description Interaction-ID: 40872 |
disease decreases_expression of gene/protein |
| Comment | In muscles of db/db mice the expression of EC 1.3.99.1 and EC 1.3.5.1 is down-regulated. |
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Formal Description Interaction-ID: 40873 |
disease decreases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for SDHA |
| Comment | In muscles of db/db mice the expression of EC 1.3.99.1 and of EC 1.3.5.1 is down-regulated. |
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Formal Description Interaction-ID: 40874 |
disease decreases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for SDHB |
| Comment | In muscles of db/db mice the expression of EC 6.2.1.5 is down-regulated. |
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Formal Description Interaction-ID: 40875 |
disease decreases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for SUCLA2 |
| Comment | In adipose tissue of db/db mice the expression of EC 2.3.1.61 is down-regulated. |
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Formal Description Interaction-ID: 40876 |
disease decreases_expression of gene/protein |
| Comment | In adipose tissue of db/db mice the expression of EC 1.2.4.2 is down-regulated. |
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Formal Description Interaction-ID: 40877 |
disease decreases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for OGDH |
| Comment | In muscles of db/db mice the expression of EC 1.1.1.41 is down-regulated. |
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Formal Description Interaction-ID: 40878 |
disease decreases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for IDH3A |
| Comment | In muscles of db/db mice the expression of IDH2 is up-regulated. |
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Formal Description Interaction-ID: 40879 |
disease increases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for IDH2 |
| Comment | In adipose tissue of db/db mice the expression of EC 4.1.3.6 is down-regulated. |
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Formal Description Interaction-ID: 40880 |
disease decreases_expression of gene/protein |
| Comment | In adipose tissue of db/db mice the expression of EC 2.3.3.1 and of EC 2.3.3.8 is down-regulated while these enzymes are up-regulated in muscles. |
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Formal Description Interaction-ID: 40881 |
disease decreases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for CS |
| Comment | In adipose tissue of db/db mice the expression of EC 2.3.3.1 and of EC 2.3.3.8 is down-regulated while these enzymes are up-regulated in muscles. |
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Formal Description Interaction-ID: 40882 |
disease increases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for CS |
| Comment | In adipose tissue of db/db mice the expression of EC 2.3.3.1 and of EC 2.3.3.8 is down-regulated while these enzymes are up-regulated in muscles. |
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Formal Description Interaction-ID: 40883 |
disease decreases_expression of gene/protein |
| Comment | In adipose tissue of db/db mice the expression of EC 2.3.3.1 and of EC 2.3.3.8 is down-regulated while these enzymes are up-regulated in muscles. |
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Formal Description Interaction-ID: 40884 |
disease increases_expression of gene/protein |
| Comment | G6PC, which is a key controlling point in gluconeogenesis, was up-regulated in liver tissue, but not in adipose tissue or muscle of diabetic db/db mice. |
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Formal Description Interaction-ID: 40885 |
disease increases_expression of gene/protein |
| Comment | Many of the metabolite and transcriptomics components of the citrate cycle were altered in the db/db mice compared to controls.Urinary concentrations of malate, citrate, cis-aconitate, 2-oxoglutarate, succinate and fumarate were all substantially increased in diabetic mice. Overlay of the liver, adipose and muscle transcriptomics results suggested that liver transcripts were up-regulated, correlating with metabolite data, while adipose genes were down-regulated. Muscle genes were also predominantly down regulated. These results are consistent with an up-regulation in citrate cycle in the liver in response to increased gluconeogenesis. |
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Formal Description Interaction-ID: 40887 |
disease increases_activity of process |
| Comment | The majority of transcripts for liver genes involved in gluconeogenesis were also up-regulated while those for adipose and muscle were down-regulated, providing additional confirmation that liver gluconeogenesis is up-regulated in the db/db mice compared to controls. |
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Formal Description Interaction-ID: 40889 |
disease increases_activity of process |
| Comment | Branched chain ketoacid dehydrogenase (BCKDHA) was down-regulated in adipose suggesting that the metabolism of branched chain amino acids (BCAAs) was altered in db/db mice. In the liver, a general increase in amino acid and amino group metabolism was observed including the BCAAs, consistent with increased protein degradation, which may be driven by the increased demand for glucogenic amino acids. |
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Formal Description Interaction-ID: 40894 |
disease decreases_activity of complex/PPI Branched-chain keto acid dehydrogenase complex |
| Comment | Branched chain ketoacid dehydrogenase (BCKDHA) was down-regulated in adipose suggesting that the metabolism of branched chain amino acids (BCAAs) was altered in db/db mice. In the liver, a general increase in amino acid and amino group metabolism was observed including the BCAAs, consistent with increased protein degradation, which may be driven by the increased demand for glucogenic amino acids. |
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Formal Description Interaction-ID: 40896 |
disease affects_activity of |
| Comment | Branched chain ketoacid dehydrogenase (BCKDHA) was down-regulated in adipose suggesting that the metabolism of branched chain amino acids (BCAAs) was altered in db/db mice. In the liver, a general increase in amino acid and amino group metabolism was observed including the BCAAs, consistent with increased protein degradation, which may be driven by the increased demand for glucogenic amino acids. |
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Formal Description Interaction-ID: 40897 |
disease increases_activity of |
| Comment | Branched chain ketoacid dehydrogenase (BCKDHA) was down-regulated in adipose suggesting that the metabolism of branched chain amino acids (BCAAs) was altered in db/db mice. In the liver, a general increase in amino acid and amino group metabolism was observed including the BCAAs, consistent with increased protein degradation, which may be driven by the increased demand for glucogenic amino acids. |
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Formal Description Interaction-ID: 40898 |
disease increases_activity of process |
| Comment | In liver of db/db mice the expression of EC 6.2.1.1 is down-regulated. |
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Formal Description Interaction-ID: 40902 |
disease decreases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for ACSS1 |
| Comment | In liver of db/db mice the expression of EC 1.2.1.12 is down-regulated. |
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Formal Description Interaction-ID: 40904 |
disease decreases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for GAPDH |
| Comment | In liver of db/db mice the expression of EC 4.1.2.13 is down-regulated. |
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Formal Description Interaction-ID: 40907 |
disease decreases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for ALDOB |
| Comment | The thermodynamically irreversible reactions that are unique to liver (and kidney) gluconeogenesis (pyruvate carboxylase PC, phosphoenolpyruvate carboxykinase PCK1, fructose 1,6-bisphosphatase FBP1, and glucose 6-phosphatase G6PC) are all up-regulated in the liver of diabetic db/db mice. |
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Formal Description Interaction-ID: 40912 |
disease increases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for PCK1 |
| Comment | The thermodynamically irreversible reactions that are unique to liver (and kidney) gluconeogenesis (pyruvate carboxylase PC, phosphoenolpyruvate carboxykinase PCK1, fructose 1,6-bisphosphatase FBP1, and glucose 6-phosphatase G6PC) are all up-regulated in the liver of diabetic db/db mice. |
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Formal Description Interaction-ID: 40913 |
disease increases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for FBP1 |
| Comment | In muscles of diabetic db/db mice the expression of EC 2.7.1.1 was down-regulated. |
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Formal Description Interaction-ID: 40918 |
disease decreases_expression of gene/protein |
| Comment | In muscles and adipose tissue of db/db mice the expression of EC 5.3.1.9 was down-regulated. |
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Formal Description Interaction-ID: 40919 |
disease decreases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for GPI |
| Comment | In muscles and adipose tissue of db/db mice the expression of EC 5.4.2.2 was down-regulated. |
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Formal Description Interaction-ID: 40920 |
disease decreases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for PGM1 |
| Comment | In adipose tissue of db/db mice the expression of EC 1.2.1.12 was down-regulated. |
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Formal Description Interaction-ID: 40923 |
disease decreases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for GAPDH |
| Comment | In adipose tissue of db/db mice the expression of EC 5.3.1.1 was up-regulated, while the enzyme was down-regulated in muscles. |
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Formal Description Interaction-ID: 40924 |
disease increases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for TPI1 |
| Comment | In adipose tissue of db/db mice the expression of EC 5.3.1.1 was up-regulated, while the enzyme was down-regulated in muscles. |
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Formal Description Interaction-ID: 40925 |
disease decreases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for TPI1 |
| Comment | In adipose tissue of db/db mice the expression of EC 4.2.1.11 was down-regulated. |
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Formal Description Interaction-ID: 40927 |
disease decreases_expression of gene/protein |
| Comment | In adipose tissue of db/db mice the expression of EC 1.1.1.27 was down-regulated. |
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Formal Description Interaction-ID: 40930 |
disease decreases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for LDHB |
| Comment | In adipose tissue of db/db mice the expression of EC 1.1.1.2 was up-regulated. |
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Formal Description Interaction-ID: 40931 |
disease increases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for AKR1A1 |
| Comment | In muscles and adipose tissue of db/db mice the expression of EC 2.3.1.12 was down-regulated. |
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Formal Description Interaction-ID: 40932 |
disease decreases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for DLAT |
| Comment | In muscles of db/db mice the expression of EC 4.1.2.13 was down-regulated. |
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Formal Description Interaction-ID: 40933 |
disease decreases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for ALDOA |
| Comment | In muscles of db/db mice the expression of EC 5.4.2.4/EC 3.1.3.13/EC 5.4.2.1 was down-regulated. |
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Formal Description Interaction-ID: 40934 |
disease decreases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for PGAM2 |
| Comment | In muscles of db/db mice the expression of EC 2.7.2.3 was down-regulated. |
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Formal Description Interaction-ID: 40935 |
disease decreases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for PGK1 |
| Comment | In muscles of db/db mice the expression of EC 2.7.1.40 was down-regulated. |
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Formal Description Interaction-ID: 40937 |
disease decreases_expression of mRNA/protein variant |
| Drugbank entries | Show/Hide entries for PKM2 |
| Comment | In muscles of db/db mice the expression of EC 2.1.4.1 was down-regulated. |
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Formal Description Interaction-ID: 40938 |
disease decreases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for GATM |
| Comment | An up-regulation in the valine, leucine and isoleucine degradation pathway was observed in liver but a down-regulation in adipose or muscle compared to non-diabetic mice. The urinary metabolite profile was increased valine with decreased degradation products 4-methyl-2-oxopentanoate, 2-oxoisopentanoate, 3-methyl-2-oxopentanoate, 3-methylbutanoate, and isobutyryl coA (excreted as isobutyrylglycine), reflecting more the events in adipose tissue than liver. |
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Formal Description Interaction-ID: 40939 |
disease increases_activity of |
| Comment | An up-regulation in the valine, leucine and isoleucine degradation pathway was observed in liver but a down-regulation in adipose or muscle compared to non-diabetic mice. The urinary metabolite profile was increased valine with decreased degradation products 4-methyl-2-oxopentanoate, 2-oxoisopentanoate, 3-methyl-2-oxopentanoate, 3-methylbutanoate, and isobutyryl coA (excreted as isobutyrylglycine), reflecting more the events in adipose tissue than liver. |
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Formal Description Interaction-ID: 40940 |
disease decreases_activity of |
| Comment | In adipose tissue of db/db mice the expression of EC 1.2.4.4 was down-regulated. |
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Formal Description Interaction-ID: 40941 |
disease decreases_expression of gene/protein |
| Comment | In adipose tissue of db/db mice the expression of EC 1.2.4.4 was down-regulated. |
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Formal Description Interaction-ID: 40942 |
disease decreases_expression of gene/protein |
| Comment | In adipose tissue of db/db mice the expression of EC 1.3.99.10 (EC 1.3.8.4) was down-regulated. |
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Formal Description Interaction-ID: 40944 |
disease decreases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for IVD |
| Comment | In addition to perturbed lipid, glucose and amino acid/ protein metabolism, links between several metabolomic markers (citrulline, glucose, sucrose, valine, N-methyl nicotinamide and its metabolites) and NOS3, and superoxide were highlighted in metabolite-centric networks. The expression of BCKDHA, MMP9, CYP2E1, and ACO1 was down-regulated in adipose tissue of db/db mice, whereas the expression of RAC1 and GLUD1 was up-regulated. |
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Formal Description Interaction-ID: 40945 |
disease decreases_expression of gene/protein |
| Comment | In addition to perturbed lipid, glucose and amino acid/ protein metabolism, links between several metabolomic markers (citrulline, glucose, sucrose, valine, N-methyl nicotinamide and its metabolites) and NOS3, and superoxide were highlighted in metabolite-centric networks. The expression of BCKDHA, MMP9, CYP2E1, and ACO1 was down-regulated in adipose tissue of db/db mice, whereas the expression of RAC1 and GLUD1 was up-regulated. |
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Formal Description Interaction-ID: 40946 |
disease decreases_expression of gene/protein |
| Comment | In addition to perturbed lipid, glucose and amino acid/ protein metabolism, links between several metabolomic markers (citrulline, glucose, sucrose, valine, N-methyl nicotinamide and its metabolites) and NOS3, and superoxide were highlighted in metabolite-centric networks. The expression of BCKDHA, MMP9, CYP2E1, and ACO1 was down-regulated in adipose tissue of db/db mice, whereas the expression of RAC1 and GLUD1 was up-regulated. |
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Formal Description Interaction-ID: 40947 |
disease decreases_expression of gene/protein |
| Comment | In addition to perturbed lipid, glucose and amino acid/ protein metabolism, links between several metabolomic markers (citrulline, glucose, sucrose, valine, N-methyl nicotinamide and its metabolites) and NOS3, and superoxide were highlighted in metabolite-centric networks. The expression of BCKDHA, MMP9, CYP2E1, and ACO1 was down-regulated in adipose tissue of db/db mice, whereas the expression of RAC1 and GLUD1 was up-regulated. |
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Formal Description Interaction-ID: 40948 |
disease increases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for RAC1 |
| Comment | In addition to perturbed lipid, glucose and amino acid/ protein metabolism, links between several metabolomic markers (citrulline, glucose, sucrose, valine, N-methyl nicotinamide and its metabolites) and NOS3, and superoxide were highlighted in metabolite-centric networks. The expression of BCKDHA, MMP9, CYP2E1, and ACO1 was down-regulated in adipose tissue of db/db mice, whereas the expression of RAC1 and GLUD1 was up-regulated. |
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Formal Description Interaction-ID: 40949 |
disease increases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for GLUD1 |