Schubert M et al.(2004) Role for neuronal insulin resistance in neurodegenerative diseases Proc. Natl. Acad. Sci. U.S.A. 101: 3100-3105
[PMID: 14981233]
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Comment
NIRKO mice represent a unique model in which to study the consequences of isolated CNS-specific disruption of IR signaling on the biochemistry and function of the brain. The reduced phosphorylation of Akt and GSK3B in brains of NIRKO mice, in the presence of otherwise intact neurotrophic signaling, demonstrates directly the relative contribution and importance of IR signaling for the activation of this pathway in the CNS.
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