General Information:

Id: 3,977
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Homo sapiens
article
Reference: Bajoria R et al.(2002) Placenta as a link between amino acids, insulin-IGF axis, and low birth weight: evidence from twin studies J. Clin. Endocrinol. Metab. 87: 308-315 [PMID: 11788666]

Interaction Information:

Comment The study determined the association between fetal nutrition and the insulin-IGF axis by measuring the plasma concentrations of amino acids, insulin, IGF-I and IGF-binding protein-1 (IGFBP-1) in maternal and cord blood from gestational age-matched dichorionic (DC) twins with (n = 10) and without discordant birth weights (n = 10). In the growth-restricted (IUGR) twins, fetal concentrations of total essential, nonessential, and branched chain amino acids were lower than those in the appropriate for gestational age co-twins and concordant twin pairs.
Formal Description
Interaction-ID: 40428

decreases_quantity of

drug/chemical compound

Valine

in umbilical venous blood
Comment The study determined the association between fetal nutrition and the insulin-IGF axis by measuring the plasma concentrations of amino acids, insulin, IGF-I and IGF-binding protein-1 (IGFBP-1) in maternal and cord blood from gestational age-matched dichorionic (DC) twins with (n = 10) and without discordant birth weights (n = 10). In the growth-restricted (IUGR) twins, fetal concentrations of total essential, nonessential, and branched chain amino acids were lower than those in the appropriate for gestational age co-twins and concordant twin pairs.
Formal Description
Interaction-ID: 40429

decreases_quantity of

drug/chemical compound

Isoleucine

in umbilical venous blood
Comment The study determined the association between fetal nutrition and the insulin-IGF axis by measuring the plasma concentrations of amino acids, insulin, IGF-I and IGF-binding protein-1 (IGFBP-1) in maternal and cord blood from gestational age-matched dichorionic (DC) twins with (n = 10) and without discordant birth weights (n = 10). In the growth-restricted (IUGR) twins, fetal concentrations of total essential, nonessential, and branched chain amino acids were lower than those in the appropriate for gestational age co-twins and concordant twin pairs.
Formal Description
Interaction-ID: 40430

decreases_quantity of

drug/chemical compound

Leucine

in umbilical venous blood
Comment The study determined the association between fetal nutrition and the insulin-IGF axis by measuring the plasma concentrations of amino acids, insulin, IGF-I and IGF-binding protein-1 (IGFBP-1) in maternal and cord blood from gestational age-matched dichorionic (DC) twins with (n = 10) and without discordant birth weights (n = 10). In the growth-restricted (IUGR) twins, fetal concentrations of total essential, nonessential, and branched chain amino acids were lower than those in the appropriate for gestational age co-twins and concordant twin pairs.
Formal Description
Interaction-ID: 40431

decreases_quantity of

drug/chemical compound

Phenylalanine

in umbilical venous blood
Comment The study determined the association between fetal nutrition and the insulin-IGF axis by measuring the plasma concentrations of amino acids, insulin, IGF-I and IGF-binding protein-1 (IGFBP-1) in maternal and cord blood from gestational age-matched dichorionic (DC) twins with (n = 10) and without discordant birth weights (n = 10). In the growth-restricted (IUGR) twins, fetal concentrations of total essential, nonessential, and branched chain amino acids were lower than those in the appropriate for gestational age co-twins and concordant twin pairs.
Formal Description
Interaction-ID: 40432

decreases_quantity of

drug/chemical compound

Lysine

in umbilical venous blood
Comment The study determined the association between fetal nutrition and the insulin-IGF axis by measuring the plasma concentrations of amino acids, insulin, IGF-I and IGF-binding protein-1 (IGFBP-1) in maternal and cord blood from gestational age-matched dichorionic (DC) twins with (n = 10) and without discordant birth weights (n = 10). In the growth-restricted (IUGR) twins, fetal concentrations of total essential, nonessential, and branched chain amino acids were lower than those in the appropriate for gestational age co-twins and concordant twin pairs.
Formal Description
Interaction-ID: 40433

decreases_quantity of

drug/chemical compound

Taurine

in umbilical venous blood
Comment The study determined the association between fetal nutrition and the insulin-IGF axis by measuring the plasma concentrations of amino acids, insulin, IGF-I and IGF-binding protein-1 (IGFBP-1) in maternal and cord blood from gestational age-matched dichorionic (DC) twins with (n = 10) and without discordant birth weights (n = 10). In the growth-restricted (IUGR) twins, fetal concentrations of total essential, nonessential, and branched chain amino acids were lower than those in the appropriate for gestational age co-twins and concordant twin pairs.
Formal Description
Interaction-ID: 40434

decreases_quantity of

drug/chemical compound

Serine

in umbilical venous blood
Comment The study determined the association between fetal nutrition and the insulin-IGF axis by measuring the plasma concentrations of amino acids, insulin, IGF-I and IGF-binding protein-1 (IGFBP-1) in maternal and cord blood from gestational age-matched dichorionic (DC) twins with (n = 10) and without discordant birth weights (n = 10). In the growth-restricted (IUGR) twins, fetal concentrations of total essential, nonessential, and branched chain amino acids were lower than those in the appropriate for gestational age co-twins and concordant twin pairs.
Formal Description
Interaction-ID: 40435

decreases_quantity of

drug/chemical compound

Glycine

in umbilical venous blood
Drugbank entries Show/Hide entries for
Comment The study determined the association between fetal nutrition and the insulin-IGF axis by measuring the plasma concentrations of amino acids, insulin, IGF-I and IGF-binding protein-1 (IGFBP-1) in maternal and cord blood from gestational age-matched dichorionic (DC) twins with (n = 10) and without discordant birth weights (n = 10). In the growth-restricted (IUGR) twins, fetal concentrations of total essential, nonessential, and branched chain amino acids were lower than those in the appropriate for gestational age co-twins and concordant twin pairs.
Formal Description
Interaction-ID: 40436

decreases_quantity of

drug/chemical compound

Tyrosine

in umbilical venous blood
Comment The study determined the association between fetal nutrition and the insulin-IGF axis by measuring the plasma concentrations of amino acids, insulin, IGF-I and IGF-binding protein-1 (IGFBP-1) in maternal and cord blood from gestational age-matched dichorionic (DC) twins with (n = 10) and without discordant birth weights (n = 10). In the growth-restricted (IUGR) twins, fetal concentrations of total essential, nonessential, and branched chain amino acids were lower than those in the appropriate for gestational age co-twins and concordant twin pairs.
Formal Description
Interaction-ID: 40437

decreases_quantity of

drug/chemical compound

Aspartate

in umbilical venous blood
Comment The study determined the association between fetal nutrition and the insulin-IGF axis by measuring the plasma concentrations of amino acids, insulin, IGF-I and IGF-binding protein-1 (IGFBP-1) in maternal and cord blood from gestational age-matched dichorionic (DC) twins with (n = 10) and without discordant birth weights (n = 10). In the growth-restricted (IUGR) twins, fetal concentrations of total essential, nonessential, and branched chain amino acids were lower than those in the appropriate for gestational age co-twins and concordant twin pairs.
Formal Description
Interaction-ID: 40438

decreases_quantity of

drug/chemical compound

Glutamate

in umbilical venous blood
Comment The IUGR twins had lower fetal concentrations of insulin and IGF-I and higher concentrations of IGFBP-1 than their appropriate for gestational age co-twins.
Formal Description
Interaction-ID: 40439

decreases_quantity of

complex/PPI

Insulin

in fetus
Comment The IUGR twins had lower fetal concentrations of insulin and IGF-I and higher concentrations of IGFBP-1 than their appropriate for gestational age co-twins.
Formal Description
Interaction-ID: 40440

decreases_quantity of

gene/protein

IGF1

in fetus
Drugbank entries Show/Hide entries for IGF1
Comment The IUGR twins had lower fetal concentrations of insulin and IGF-I and higher concentrations of IGFBP-1 than their appropriate for gestational age co-twins.
Formal Description
Interaction-ID: 40441

increases_quantity of

gene/protein

IGFBP1

in fetus
Comment In the discordant group, fetal IGFBP-1 had a negative association with fetal insulin, total essential amino acids, and branched chain amino acids. There was a positive correlation between total essential amino acids and branched chain amino acids and plasma insulin. However, there were no associations among fetal insulin, IGFBP-1 and nonessential amino acids. These data demonstrate the link between the reduction in certain essential and nonessential amino acids and alterations in fetal circulating levels of insulin and IGFBP-1, in growth-restricted twins. A disturbance in the pathways of placental transport of amino acids causes an alteration in the fetal insulin-IGF axis, which then causes IUGR in one of the DC twins.
Formal Description
Interaction-ID: 40442

process

placental amino acid transport

affects_activity of

process

insulin-IGF axis

in fetus