General Information:
Id: | 3,977 |
Diseases: |
Diabetes mellitus, type II
- [OMIM]
Insulin resistance |
Homo sapiens | |
article | |
Reference: | Bajoria R et al.(2002) Placenta as a link between amino acids, insulin-IGF axis, and low birth weight: evidence from twin studies J. Clin. Endocrinol. Metab. 87: 308-315 [PMID: 11788666] |
Interaction Information:
Comment | The study determined the association between fetal nutrition and the insulin-IGF axis by measuring the plasma concentrations of amino acids, insulin, IGF-I and IGF-binding protein-1 (IGFBP-1) in maternal and cord blood from gestational age-matched dichorionic (DC) twins with (n = 10) and without discordant birth weights (n = 10). In the growth-restricted (IUGR) twins, fetal concentrations of total essential, nonessential, and branched chain amino acids were lower than those in the appropriate for gestational age co-twins and concordant twin pairs. |
Formal Description Interaction-ID: 40428 |
phenotype decreases_quantity of drug/chemical compound |
Comment | The study determined the association between fetal nutrition and the insulin-IGF axis by measuring the plasma concentrations of amino acids, insulin, IGF-I and IGF-binding protein-1 (IGFBP-1) in maternal and cord blood from gestational age-matched dichorionic (DC) twins with (n = 10) and without discordant birth weights (n = 10). In the growth-restricted (IUGR) twins, fetal concentrations of total essential, nonessential, and branched chain amino acids were lower than those in the appropriate for gestational age co-twins and concordant twin pairs. |
Formal Description Interaction-ID: 40429 |
phenotype decreases_quantity of drug/chemical compound |
Comment | The study determined the association between fetal nutrition and the insulin-IGF axis by measuring the plasma concentrations of amino acids, insulin, IGF-I and IGF-binding protein-1 (IGFBP-1) in maternal and cord blood from gestational age-matched dichorionic (DC) twins with (n = 10) and without discordant birth weights (n = 10). In the growth-restricted (IUGR) twins, fetal concentrations of total essential, nonessential, and branched chain amino acids were lower than those in the appropriate for gestational age co-twins and concordant twin pairs. |
Formal Description Interaction-ID: 40430 |
phenotype decreases_quantity of drug/chemical compound |
Comment | The study determined the association between fetal nutrition and the insulin-IGF axis by measuring the plasma concentrations of amino acids, insulin, IGF-I and IGF-binding protein-1 (IGFBP-1) in maternal and cord blood from gestational age-matched dichorionic (DC) twins with (n = 10) and without discordant birth weights (n = 10). In the growth-restricted (IUGR) twins, fetal concentrations of total essential, nonessential, and branched chain amino acids were lower than those in the appropriate for gestational age co-twins and concordant twin pairs. |
Formal Description Interaction-ID: 40431 |
phenotype decreases_quantity of drug/chemical compound |
Comment | The study determined the association between fetal nutrition and the insulin-IGF axis by measuring the plasma concentrations of amino acids, insulin, IGF-I and IGF-binding protein-1 (IGFBP-1) in maternal and cord blood from gestational age-matched dichorionic (DC) twins with (n = 10) and without discordant birth weights (n = 10). In the growth-restricted (IUGR) twins, fetal concentrations of total essential, nonessential, and branched chain amino acids were lower than those in the appropriate for gestational age co-twins and concordant twin pairs. |
Formal Description Interaction-ID: 40432 |
phenotype decreases_quantity of drug/chemical compound |
Comment | The study determined the association between fetal nutrition and the insulin-IGF axis by measuring the plasma concentrations of amino acids, insulin, IGF-I and IGF-binding protein-1 (IGFBP-1) in maternal and cord blood from gestational age-matched dichorionic (DC) twins with (n = 10) and without discordant birth weights (n = 10). In the growth-restricted (IUGR) twins, fetal concentrations of total essential, nonessential, and branched chain amino acids were lower than those in the appropriate for gestational age co-twins and concordant twin pairs. |
Formal Description Interaction-ID: 40433 |
phenotype decreases_quantity of drug/chemical compound |
Comment | The study determined the association between fetal nutrition and the insulin-IGF axis by measuring the plasma concentrations of amino acids, insulin, IGF-I and IGF-binding protein-1 (IGFBP-1) in maternal and cord blood from gestational age-matched dichorionic (DC) twins with (n = 10) and without discordant birth weights (n = 10). In the growth-restricted (IUGR) twins, fetal concentrations of total essential, nonessential, and branched chain amino acids were lower than those in the appropriate for gestational age co-twins and concordant twin pairs. |
Formal Description Interaction-ID: 40434 |
phenotype decreases_quantity of drug/chemical compound |
Comment | The study determined the association between fetal nutrition and the insulin-IGF axis by measuring the plasma concentrations of amino acids, insulin, IGF-I and IGF-binding protein-1 (IGFBP-1) in maternal and cord blood from gestational age-matched dichorionic (DC) twins with (n = 10) and without discordant birth weights (n = 10). In the growth-restricted (IUGR) twins, fetal concentrations of total essential, nonessential, and branched chain amino acids were lower than those in the appropriate for gestational age co-twins and concordant twin pairs. |
Formal Description Interaction-ID: 40435 |
phenotype decreases_quantity of drug/chemical compound |
Drugbank entries | Show/Hide entries for |
Comment | The study determined the association between fetal nutrition and the insulin-IGF axis by measuring the plasma concentrations of amino acids, insulin, IGF-I and IGF-binding protein-1 (IGFBP-1) in maternal and cord blood from gestational age-matched dichorionic (DC) twins with (n = 10) and without discordant birth weights (n = 10). In the growth-restricted (IUGR) twins, fetal concentrations of total essential, nonessential, and branched chain amino acids were lower than those in the appropriate for gestational age co-twins and concordant twin pairs. |
Formal Description Interaction-ID: 40436 |
phenotype decreases_quantity of drug/chemical compound |
Comment | The study determined the association between fetal nutrition and the insulin-IGF axis by measuring the plasma concentrations of amino acids, insulin, IGF-I and IGF-binding protein-1 (IGFBP-1) in maternal and cord blood from gestational age-matched dichorionic (DC) twins with (n = 10) and without discordant birth weights (n = 10). In the growth-restricted (IUGR) twins, fetal concentrations of total essential, nonessential, and branched chain amino acids were lower than those in the appropriate for gestational age co-twins and concordant twin pairs. |
Formal Description Interaction-ID: 40437 |
phenotype decreases_quantity of drug/chemical compound |
Comment | The study determined the association between fetal nutrition and the insulin-IGF axis by measuring the plasma concentrations of amino acids, insulin, IGF-I and IGF-binding protein-1 (IGFBP-1) in maternal and cord blood from gestational age-matched dichorionic (DC) twins with (n = 10) and without discordant birth weights (n = 10). In the growth-restricted (IUGR) twins, fetal concentrations of total essential, nonessential, and branched chain amino acids were lower than those in the appropriate for gestational age co-twins and concordant twin pairs. |
Formal Description Interaction-ID: 40438 |
phenotype decreases_quantity of drug/chemical compound |
Comment | The IUGR twins had lower fetal concentrations of insulin and IGF-I and higher concentrations of IGFBP-1 than their appropriate for gestational age co-twins. |
Formal Description Interaction-ID: 40439 |
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Comment | The IUGR twins had lower fetal concentrations of insulin and IGF-I and higher concentrations of IGFBP-1 than their appropriate for gestational age co-twins. |
Formal Description Interaction-ID: 40440 |
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Drugbank entries | Show/Hide entries for IGF1 |
Comment | The IUGR twins had lower fetal concentrations of insulin and IGF-I and higher concentrations of IGFBP-1 than their appropriate for gestational age co-twins. |
Formal Description Interaction-ID: 40441 |
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Comment | In the discordant group, fetal IGFBP-1 had a negative association with fetal insulin, total essential amino acids, and branched chain amino acids. There was a positive correlation between total essential amino acids and branched chain amino acids and plasma insulin. However, there were no associations among fetal insulin, IGFBP-1 and nonessential amino acids. These data demonstrate the link between the reduction in certain essential and nonessential amino acids and alterations in fetal circulating levels of insulin and IGFBP-1, in growth-restricted twins. A disturbance in the pathways of placental transport of amino acids causes an alteration in the fetal insulin-IGF axis, which then causes IUGR in one of the DC twins. |
Formal Description Interaction-ID: 40442 |
process placental amino acid transport affects_activity of process insulin-IGF axis |