CIDeRplusGeneral Information:
| Id: | 3,889 |
| Diseases: |
Diabetes mellitus, type II
- [OMIM]
Insulin resistance |
| Homo sapiens | |
| article | |
| Reference: | Gall WE et al.(2010) alpha-hydroxybutyrate is an early biomarker of insulin resistance and glucose intolerance in a nondiabetic population PLoS ONE 5 [PMID: 20526369] |
Interaction Information:
| Comment | Random forest statistical analysis selected alpha-hydroxybutyrate (alpha-HB) as the top-ranked biochemical for separating insulin resistant from insulin sensitive subjectswith a 76% accuracy. By partition analysis, an alpha-HB value of 5 microg/ml was found to best separate insulin resistant from insulin sensitive subjects. alpha-HB also separated subjects with normal glucose tolerance from those with impaired fasting glycemia or impaired glucose tolerance independently of, and in an additive fashion to, insulin resistance. These associations were also independent of sex, age and BMI. alpha-hydroxybutyrate is an early marker for both insulin resistance and impaired glucose regulation. |
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Formal Description Interaction-ID: 39263 |
disease Insulin resistance increases_quantity of drug/chemical compound |
| Comment | Random forest statistical analysis selected alpha-hydroxybutyrate (alpha-HB) as the top-ranked biochemical for separating insulin resistant from insulin sensitive subjectswith a 76% accuracy. By partition analysis, an alpha-HB value of 5 microg/ml was found to best separate insulin resistant from insulin sensitive subjects. alpha-HB also separated subjects with normal glucose tolerance from those with impaired fasting glycemia or impaired glucose tolerance independently of, and in an additive fashion to, insulin resistance. These associations were also independent of sex, age and BMI. alpha-hydroxybutyrate is an early marker for both insulin resistance and impaired glucose regulation. |
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Formal Description Interaction-ID: 39264 |
phenotype increases_quantity of drug/chemical compound |
| Comment | Other metabolites from this global analysis that significantly correlated to insulin sensitivity included certain organic acid, amino acid, lysophospholipid, acylcarnitine and fatty acid species. |
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Formal Description Interaction-ID: 39265 |
disease Insulin resistance decreases_quantity of drug/chemical compound |
| Comment | Other metabolites from this global analysis that significantly correlated to insulin sensitivity included certain organic acid, amino acid, lysophospholipid, acylcarnitine and fatty acid species. |
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Formal Description Interaction-ID: 39266 |
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| Drugbank entries | Show/Hide entries for |
| Comment | Other metabolites from this global analysis that significantly correlated to insulin sensitivity included certain organic acid, amino acid, lysophospholipid, acylcarnitine and fatty acid species. |
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Formal Description Interaction-ID: 39267 |
disease Insulin resistance increases_quantity of drug/chemical compound |
| Comment | Other metabolites from this global analysis that significantly correlated to insulin sensitivity included certain organic acid, amino acid, lysophospholipid, acylcarnitine and fatty acid species. |
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Formal Description Interaction-ID: 39268 |
disease Insulin resistance decreases_quantity of drug/chemical compound |
| Comment | Other metabolites from this global analysis that significantly correlated to insulin sensitivity included certain organic acid, amino acid, lysophospholipid, acylcarnitine and fatty acid species. |
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Formal Description Interaction-ID: 39269 |
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| Drugbank entries | Show/Hide entries for |
| Comment | Other metabolites from this global analysis that significantly correlated to insulin sensitivity included certain organic acid, amino acid, lysophospholipid, acylcarnitine and fatty acid species. |
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Formal Description Interaction-ID: 39270 |
disease Insulin resistance decreases_quantity of drug/chemical compound Decanoylcarnitine |
| Comment | Other metabolites from this global analysis that significantly correlated to insulin sensitivity included certain organic acid, amino acid, lysophospholipid, acylcarnitine and fatty acid species. |
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Formal Description Interaction-ID: 39271 |
disease Insulin resistance decreases_quantity of drug/chemical compound |
| Comment | Other metabolites from this global analysis that significantly correlated to insulin sensitivity included certain organic acid, amino acid, lysophospholipid, acylcarnitine and fatty acid species. |
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Formal Description Interaction-ID: 39272 |
disease Insulin resistance decreases_quantity of drug/chemical compound 1-Stearoylglycerophosphocholine |
| Comment | Other metabolites from this global analysis that significantly correlated to insulin sensitivity included certain organic acid, amino acid, lysophospholipid, acylcarnitine and fatty acid species. |
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Formal Description Interaction-ID: 39273 |
disease Insulin resistance increases_quantity of drug/chemical compound |
| Comment | Other metabolites from this global analysis that significantly correlated to insulin sensitivity included certain organic acid, amino acid, lysophospholipid, acylcarnitine and fatty acid species. |
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Formal Description Interaction-ID: 39274 |
disease Insulin resistance increases_quantity of drug/chemical compound |
| Drugbank entries | Show/Hide entries for |
| Comment | Other metabolites from this global analysis that significantly correlated to insulin sensitivity included certain organic acid, amino acid, lysophospholipid, acylcarnitine and fatty acid species. |
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Formal Description Interaction-ID: 39275 |
disease Insulin resistance decreases_quantity of drug/chemical compound |
| Comment | Other metabolites from this global analysis that significantly correlated to insulin sensitivity included certain organic acid, amino acid, lysophospholipid, acylcarnitine and fatty acid species. |
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Formal Description Interaction-ID: 39276 |
disease Insulin resistance increases_quantity of drug/chemical compound |
| Drugbank entries | Show/Hide entries for |
| Comment | Other metabolites from this global analysis that significantly correlated to insulin sensitivity included certain organic acid, amino acid, lysophospholipid, acylcarnitine and fatty acid species. |
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Formal Description Interaction-ID: 39277 |
disease Insulin resistance increases_quantity of drug/chemical compound Heptadecanoic acid |
| Comment | Alpha-hydroxybutyrate (alpha-HB) is an organic acid derived from alpha-ketobutyrate (alpha-KB). Alpha-HB may become elevated by at least two mechanisms: (1) elevation of hepatic glutathione stress resulting in an increased demand for glutathione production, and (2) elevation of the NADH/NAD+ ratio due to increased lipid oxidation. The first mechanism likely contributes to increased alpha-HB formation by supplying more alpha-KB substrate from increased cysteine anabolism. Consistent with this interpretation, the study showed statistically significant elevation of both alpha-KB and cysteine with increasing insulin resistance from the global screening data. |
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Formal Description Interaction-ID: 39278 |
disease Insulin resistance increases_quantity of drug/chemical compound |
| Comment | Alpha-hydroxybutyrate (alpha-HB) is an organic acid derived from alpha-ketobutyrate (alpha-KB). Alpha-HB may become elevated by at least two mechanisms: (1) elevation of hepatic glutathione stress resulting in an increased demand for glutathione production, and (2) elevation of the NADH/NAD+ ratio due to increased lipid oxidation. The first mechanism likely contributes to increased alpha-HB formation by supplying more alpha-KB substrate from increased cysteine anabolism. Consistent with this interpretation, the study showed statistically significant elevation of both alpha-KB and cysteine with increasing insulin resistance from the global screening data. |
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Formal Description Interaction-ID: 39281 |
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