General Information:

Id: 385 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Homo sapiens
BTO:0003350 BV-2 cell
article
Reference: Liu Y et al.(2009) Expression of amyotrophic lateral sclerosis-linked SOD1 mutant increases the neurotoxic potential of microglia via TLR2 J. Biol. Chem. 284: 3691-3699 [PMID: 19091752]

Interaction Information:

Comment When oxidative stress upon TLR2 or TLR4 stimulation was compared between different cell types, mSOD1(G93A) overexpression was observed to result in significantly higher levels of H2O2 and lower concentrations of thiol groups in the cell lysate.
Formal Description
Interaction-ID: 1592

gene/protein mutant

SOD1-p.G93A

increases_activity of

process

response to oxidative stress

in TLR2 or TLR4 stimulated murine microglial cell line BV-2; if SOD1(G93A) is overexpressed
Comment P47-PHOX mediates SOD1 G93A mutation-enhanced oxidative stress and subsequent TNF-alpha secretion following TLR2 stimulation.
Formal Description
Interaction-ID: 1595

gene/protein

NCF1

affects_activity of

process

response to oxidative stress

in TLR2 stimulated murine microglial cell line BV-2; if SOD1(G93A) is overexpressed