CIDeRplusGeneral Information:
| Id: | 379 (click here to show other Interactions for entry) |
| Diseases: |
Amyotrophic lateral sclerosis
|
| Mus musculus | |
| SOD1(G93A) transgenic mouse | |
| BTO:0001279 spinal cord | |
| article | |
| Reference: | Petri S et al.(2007) The lipophilic metal chelators DP-109 and DP-460 are neuroprotective in a transgenic mouse model of amyotrophic lateral sclerosis J. Neurochem. 102: 991-1000 [PMID: 17630988] |
Interaction Information:
| Comment | Treatment of SOD1(G93A) transgenic mice with the lipophilic metal chelators DP-109 and DP-460 (calcium, zinc, and copper chelating compounds) resulted in decreased oxidative stress. DP-109 and DP-460 are diester derivatives of BAPTA [1,2-bis(2-aminophenyloxy)ethane-N,N,N',N'-tetra acetic acid]. |
|
Formal Description Interaction-ID: 1554 |
drug/chemical compound Lipophilic metal chelator DP-460 decreases_activity of process |