General Information:

Id: 370
Diseases: Amyotrophic lateral sclerosis
Mus musculus
mouse injured by unilateral sciatic nerve avulsion
BTO:0000312 motoneuron
article
Reference: Martin LJ et al.(2005) Adult motor neuron apoptosis is mediated by nitric oxide and Fas death receptor linked by DNA damage and p53 activation J. Neurosci. 25: 6449-6459 [PMID: 16000635]

Interaction Information:

Comment Unilateral avulsion of the sciatic nerve in the mouse induces apoptosis of spinal motor neurons (MNs).
Formal Description
Interaction-ID: 1486

environment

injury by unilateral sciatic nerve avulsion

increases_activity of

phenotype

motor neuron degeneration

Comment Unilateral avulsion of the sciatic nerve in the mouse induces apoptosis of spinal motor neurons (MNs).
Formal Description
Interaction-ID: 1488

environment

injury by unilateral sciatic nerve avulsion

increases_activity of

process

neuron apoptotic process

Comment The lack of a functional Fas receptor conferred motor neuron protection after sciatic nerve avulsion (SNA). Immunoblots showed increased levels of Fas death receptor protein in the ipsilateral ventral horn at 5 d after sciatic nerve avulsion (SNA) accompanied by increased levels of the active cleavage product of caspase-8.
Formal Description
Interaction-ID: 1489

environment

injury by unilateral sciatic nerve avulsion

increases_expression of

gene/protein

FAS

Drugbank entries Show/Hide entries for FAS
Comment The lack of a functional Fas receptor conferred motor neuron protection after sciatic nerve avulsion (SNA). Immunoblots showed increased levels of Fas death receptor protein in the ipsilateral ventral horn at 5 d after sciatic nerve avulsion (SNA) accompanied by increased levels of the active cleavage product of caspase-8.
Formal Description
Interaction-ID: 1492

environment

injury by unilateral sciatic nerve avulsion

increases_expression of

gene/protein

CASP8

Comment The lack of a functional Fas receptor conferred motor neuron protection after sciatic nerve avulsion (SNA).
Formal Description
Interaction-ID: 1493

gene/protein

FAS

increases_activity of

process

neuron apoptotic process

Drugbank entries Show/Hide entries for FAS
Comment Deletion of Fas ligand protected partially against the motor neuron apoptosis after sciatic nerve avulsion (SNA)
Formal Description
Interaction-ID: 1494

gene/protein

FASLG

affects_activity of

process

neuron apoptotic process

Comment Mice deficient in nNOS and iNOS were protected from the apoptosis of motor neurons induced by sciatic nerve avulsion (SNA).
Formal Description
Interaction-ID: 1495

gene/protein

NOS1

increases_activity of

process

neuron apoptotic process

Drugbank entries Show/Hide entries for NOS1
Comment Mice deficient in nNOS and iNOS were protected from the apoptosis of motor neurons induced by sciatic nerve avulsion (SNA).
Formal Description
Interaction-ID: 1496

gene/protein

NOS2

increases_activity of

process

neuron apoptotic process

Drugbank entries Show/Hide entries for NOS2
Comment NO levels progressively increased in ipsilateral motor neurons after sciatic nerve avulsion (SNA).
Formal Description
Interaction-ID: 1501

environment

injury by unilateral sciatic nerve avulsion

increases_quantity of

drug/chemical compound

NO

Comment The peroxynitrite- signal was not detectable in nonlesioned motor neurons. Peroxynitrite- production was elevated in motor neurons injured by sciatic nerve avulsion (SNA).
Formal Description
Interaction-ID: 1503

environment

injury by unilateral sciatic nerve avulsion

increases_quantity of

drug/chemical compound

Peroxynitrite