General Information:

Id: 3,699 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mammalia
review
Reference: Cai H et al.(2012) Metabolic dysfunction in Alzheimers disease and related neurodegenerative disorders Curr Alzheimer Res 9: 5-17 [PMID: 22329649]

Interaction Information:

Comment The presence of type 2 DM and the ApoE4 allele together has also been shown to increase the risk of developing AD, to more than five-fold, compared to individuals without those two conditions.
Formal Description
Interaction-ID: 35842

gene/protein mutant

APOE (isoform E4)

increases_activity of

disease

Alzheimer disease

In the presence of type 2 DM the risk of developing AD is increased to more than five-fold, compared to individuals without those two conditions.