General Information:

Id: 3,656 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mammalia
review
Reference: Newsholme P et al.(2007) Amino acid metabolism, insulin secretion and diabetes Biochem. Soc. Trans. 35: 1180-1186 [PMID: 17956307]

Interaction Information:

Comment As glutamate is known to inhibit glucagon secretion from the pancreatic alpha-cell, glutamate release from the beta-cell may additionally represent a novel paracrine mechanism for pancreatic islet hormone release.
Formal Description
Interaction-ID: 34839

drug/chemical compound

Glutamate

decreases_activity of

process

glucagon secretion

in pancreatic alpha cells