CIDeRplusGeneral Information:
| Id: | 3,656 (click here to show other Interactions for entry) |
| Diseases: |
Diabetes mellitus, type II
- [OMIM]
Insulin resistance |
| Mammalia | |
| review | |
| Reference: | Newsholme P et al.(2007) Amino acid metabolism, insulin secretion and diabetes Biochem. Soc. Trans. 35: 1180-1186 [PMID: 17956307] |
Interaction Information:
| Comment | Amino acids may modulate lipid metabolism. ACC, responsible for malonyl-CoA synthesis, is activated by glutamate-sensitive protein phosphatase type 2A, an effect demonstrated in islet beta-cells. ACC is also regulated by phosphorylation via AMP-regulated kinase, an enzyme sensitive to amino acid concentration. |
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Formal Description Interaction-ID: 34809 |
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