CIDeRplusGeneral Information:
| Id: | 3,651 |
| Diseases: |
Diabetes mellitus, type II
- [OMIM]
Insulin resistance |
| Homo sapiens | |
| article | |
| Reference: | Wang-Sattler R et al.(2012) Novel biomarkers for pre-diabetes identified by metabolomics Mol. Syst. Biol. 8: 615 [PMID: 23010998] |
Interaction Information:
| Comment | The study revealed significant metabolic variation in pre-diabetic individuals that are distinct from known diabetes risk indicators, such as glycosylated hemoglobin levels, fasting glucose and insulin. The study identified three metabolites (glycine, lysophosphatidylcholine (LPC) (18:2) and acetylcarnitine) that had significantly altered levels in IGT individuals as compared to those with normal glucose tolerance. Lower levels of glycine and LPC were found to be predictors not only for IGT but also for T2D. |
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Formal Description Interaction-ID: 34676 |
phenotype decreases_quantity of drug/chemical compound |
| Drugbank entries | Show/Hide entries for |
| Comment | The study revealed significant metabolic variation in pre-diabetic individuals that are distinct from known diabetes risk indicators, such as glycosylated hemoglobin levels, fasting glucose and insulin. The study identified three metabolites (glycine, lysophosphatidylcholine (LPC) (18:2) and acetylcarnitine) that had significantly altered levels in IGT individuals as compared to those with normal glucose tolerance. Lower levels of glycine and LPC were found to be predictors not only for IGT but also for T2D. |
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Formal Description Interaction-ID: 34677 |
phenotype decreases_quantity of drug/chemical compound LysoPC(18:2) |
| Comment | The study revealed significant metabolic variation in pre-diabetic individuals that are distinct from known diabetes risk indicators, such as glycosylated hemoglobin levels, fasting glucose and insulin. The study identified three metabolites (glycine, lysophosphatidylcholine (LPC) (18:2) and acetylcarnitine) that had significantly altered levels in IGT individuals as compared to those with normal glucose tolerance. Lower levels of glycine and LPC were found to be predictors not only for IGT but also for T2D. |
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Formal Description Interaction-ID: 34678 |
phenotype increases_quantity of drug/chemical compound |
| Comment | Gene expression analysis in whole-blood samples of participants from the KORA S4 revealed significant variations of transcript levels of four enzymes, namely, carnitine/acylcarnitine translocase (CAC), carnitine acetyltransferase (CrAT), 5-aminolevulinate synthase 1 (ALAS-H) and cytosolic phospholipase A2 (cPLA2), which are known to be strongly associated with the levels of the three metabolites. The clear relationship between changes in metabolites and transcription levels of associated enzymes strongly suggests that these metabolites are functionally associated with T2D genes in established pathways. |
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Formal Description Interaction-ID: 34679 |
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| Drugbank entries | Show/Hide entries for SLC25A20 |
| Comment | Gene expression analysis in whole-blood samples of participants from the KORA S4 revealed significant variations of transcript levels of four enzymes, namely, carnitine/acylcarnitine translocase (CAC), carnitine acetyltransferase (CrAT), 5-aminolevulinate synthase 1 (ALAS-H) and cytosolic phospholipase A2 (cPLA2), which are known to be strongly associated with the levels of the three metabolites. The clear relationship between changes in metabolites and transcription levels of associated enzymes strongly suggests that these metabolites are functionally associated with T2D genes in established pathways. |
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Formal Description Interaction-ID: 34680 |
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| Drugbank entries | Show/Hide entries for CRAT |
| Comment | Gene expression analysis in whole-blood samples of participants from the KORA S4 revealed significant variations of transcript levels of four enzymes, namely, carnitine/acylcarnitine translocase (CAC), carnitine acetyltransferase (CrAT), 5-aminolevulinate synthase 1 (ALAS-H) and cytosolic phospholipase A2 (cPLA2), which are known to be strongly associated with the levels of the three metabolites. The clear relationship between changes in metabolites and transcription levels of associated enzymes strongly suggests that these metabolites are functionally associated with T2D genes in established pathways. |
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Formal Description Interaction-ID: 34681 |
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| Drugbank entries | Show/Hide entries for ALAS1 |
| Comment | Gene expression analysis in whole-blood samples of participants from the KORA S4 revealed significant variations of transcript levels of four enzymes, namely, carnitine/acylcarnitine translocase (CAC), carnitine acetyltransferase (CrAT), 5-aminolevulinate synthase 1 (ALAS-H) and cytosolic phospholipase A2 (cPLA2), which are known to be strongly associated with the levels of the three metabolites. The clear relationship between changes in metabolites and transcription levels of associated enzymes strongly suggests that these metabolites are functionally associated with T2D genes in established pathways. |
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Formal Description Interaction-ID: 34682 |
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| Drugbank entries | Show/Hide entries for PLA2G4A |
| Comment | To investigate the underlying molecular mechanism for the three identified IGT metabolites, their associations with T2D-related genes were studied by analyzing protein-metabolite interaction networks. In all, 7 out of the 46 known T2D-related genes (PPARG, TCF7L2, HNF1A, GCK, IGF1, IRS1 and IDE) were linked to these metabolites through related enzymes or proteins. |
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Formal Description Interaction-ID: 34683 |
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| Drugbank entries | Show/Hide entries for PPARG |
| Comment | To investigate the underlying molecular mechanism for the three identified IGT metabolites, their associations with T2D-related genes were studied by analyzing protein-metabolite interaction networks. In all, 7 out of the 46 known T2D-related genes (PPARG, TCF7L2, HNF1A, GCK, IGF1, IRS1 and IDE) were linked to these metabolites through related enzymes or proteins. |
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Formal Description Interaction-ID: 34713 |
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| Drugbank entries | Show/Hide entries for PPARG or Glycine |
| Comment | To investigate the underlying molecular mechanism for the three identified IGT metabolites, their associations with T2D-related genes were studied by analyzing protein-metabolite interaction networks. In all, 7 out of the 46 known T2D-related genes (PPARG, TCF7L2, HNF1A, GCK, IGF1, IRS1 and IDE) were linked to these metabolites through related enzymes or proteins. |
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Formal Description Interaction-ID: 34714 |
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| Drugbank entries | Show/Hide entries for |
| Comment | To investigate the underlying molecular mechanism for the three identified IGT metabolites, their associations with T2D-related genes were studied by analyzing protein-metabolite interaction networks. In all, 7 out of the 46 known T2D-related genes (PPARG, TCF7L2, HNF1A, GCK, IGF1, IRS1 and IDE) were linked to these metabolites through related enzymes or proteins. |
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Formal Description Interaction-ID: 34715 |
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| Drugbank entries | Show/Hide entries for HNF1A or Glycine |
| Comment | To investigate the underlying molecular mechanism for the three identified IGT metabolites, their associations with T2D-related genes were studied by analyzing protein-metabolite interaction networks. In all, 7 out of the 46 known T2D-related genes (PPARG, TCF7L2, HNF1A, GCK, IGF1, IRS1 and IDE) were linked to these metabolites through related enzymes or proteins. |
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Formal Description Interaction-ID: 34716 |
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| Drugbank entries | Show/Hide entries for GCK or Glycine |
| Comment | To investigate the underlying molecular mechanism for the three identified IGT metabolites, their associations with T2D-related genes were studied by analyzing protein-metabolite interaction networks. In all, 7 out of the 46 known T2D-related genes (PPARG, TCF7L2, HNF1A, GCK, IGF1, IRS1 and IDE) were linked to these metabolites through related enzymes or proteins. |
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Formal Description Interaction-ID: 34718 |
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| Drugbank entries | Show/Hide entries for IGF1 or Glycine |
| Comment | To investigate the underlying molecular mechanism for the three identified IGT metabolites, their associations with T2D-related genes were studied by analyzing protein-metabolite interaction networks. In all, 7 out of the 46 known T2D-related genes (PPARG, TCF7L2, HNF1A, GCK, IGF1, IRS1 and IDE) were linked to these metabolites through related enzymes or proteins. |
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Formal Description Interaction-ID: 34719 |
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| Drugbank entries | Show/Hide entries for IGF1 |
| Comment | To investigate the underlying molecular mechanism for the three identified IGT metabolites, their associations with T2D-related genes were studied by analyzing protein-metabolite interaction networks. In all, 7 out of the 46 known T2D-related genes (PPARG, TCF7L2, HNF1A, GCK, IGF1, IRS1 and IDE) were linked to these metabolites through related enzymes or proteins. |
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Formal Description Interaction-ID: 34721 |
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| Drugbank entries | Show/Hide entries for IRS1 or Glycine |
| Comment | To investigate the underlying molecular mechanism for the three identified IGT metabolites, their associations with T2D-related genes were studied by analyzing protein-metabolite interaction networks. In all, 7 out of the 46 known T2D-related genes (PPARG, TCF7L2, HNF1A, GCK, IGF1, IRS1 and IDE) were linked to these metabolites through related enzymes or proteins. |
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Formal Description Interaction-ID: 34722 |
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| Drugbank entries | Show/Hide entries for IRS1 |
| Comment | To investigate the underlying molecular mechanism for the three identified IGT metabolites, their associations with T2D-related genes were studied by analyzing protein-metabolite interaction networks. In all, 7 out of the 46 known T2D-related genes (PPARG, TCF7L2, HNF1A, GCK, IGF1, IRS1 and IDE) were linked to these metabolites through related enzymes or proteins. |
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Formal Description Interaction-ID: 34723 |
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| Drugbank entries | Show/Hide entries for IDE |
| Comment | To investigate the underlying molecular mechanism for the three identified IGT metabolites, their associations with T2D-related genes were studied by analyzing protein-metabolite interaction networks. In all, 7 out of the 46 known T2D-related genes (PPARG, TCF7L2, HNF1A, GCK, IGF1, IRS1 and IDE) were linked to these metabolites through related enzymes or proteins. |
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Formal Description Interaction-ID: 34724 |
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| Drugbank entries | Show/Hide entries for IDE or Glycine |