General Information:

Id: 3,562 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Homo sapiens
article
Reference: Bao Y et al.(2009) Metabonomic variations in the drug-treated type 2 diabetes mellitus patients and healthy volunteers J. Proteome Res. 8: 1623-1630 [PMID: 19714868]

Interaction Information:

Comment Multivariate statistics indicated the rosiglitazone-mediated normalization of 8-10 key metabolites at 24 and 48 weeks, which were differentially expressed in diabetic subjects, involving glutamate, maltose, butanoate, glucuronolactone, C16:0, C18:1. In repaglinide and metformin groups, only glutamate and lysine (in repaglinide group at 48 week only) were brought to the normal level.
Formal Description
Interaction-ID: 33208

drug/chemical compound

Metformin

decreases_quantity of

drug/chemical compound

Glutamate

in blood serum; in diabetic patients
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