General Information:

Id: 3,561
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Homo sapiens
article
Reference: Huffman KM et al.(2012) Caloric restriction alters the metabolic response to a mixed-meal: results from a randomized, controlled trial PLoS ONE 7 [PMID: 22523532]

Interaction Information:

Comment Using PCA to analyze changes in the fasting-to-postprandial difference (FPPD), we identified single components for FPPD for each of the major analyte modules, free fatty acids FFA, acylcarnitines AC, and amino acids AA, with eigenvalues of 6.37, 8.67, and 7.88 respectively, explaining 80%, 20% and 53% of the variance in the component. At the initial assessment, individual FFA and AC metabolites generally decreased from fasting to the postprandial state, particularly those that loaded heavily as part of the FFA and AC components. In contrast, individual AA concentrations increased in the transition to the postprandial state.
Formal Description
Interaction-ID: 33143

environment

feeding after fasting

decreases_quantity of

drug/chemical compound

Myristic acid

in blood plasma
Drugbank entries Show/Hide entries for
Comment Using PCA to analyze changes in the fasting-to-postprandial difference (FPPD), we identified single components for FPPD for each of the major analyte modules, free fatty acids FFA, acylcarnitines AC, and amino acids AA, with eigenvalues of 6.37, 8.67, and 7.88 respectively, explaining 80%, 20% and 53% of the variance in the component. At the initial assessment, individual FFA and AC metabolites generally decreased from fasting to the postprandial state, particularly those that loaded heavily as part of the FFA and AC components. In contrast, individual AA concentrations increased in the transition to the postprandial state.
Formal Description
Interaction-ID: 33144

environment

feeding after fasting

decreases_quantity of

drug/chemical compound

Palmitoleic acid

in blood plasma
Drugbank entries Show/Hide entries for
Comment Using PCA to analyze changes in the fasting-to-postprandial difference (FPPD), we identified single components for FPPD for each of the major analyte modules, free fatty acids FFA, acylcarnitines AC, and amino acids AA, with eigenvalues of 6.37, 8.67, and 7.88 respectively, explaining 80%, 20% and 53% of the variance in the component. At the initial assessment, individual FFA and AC metabolites generally decreased from fasting to the postprandial state, particularly those that loaded heavily as part of the FFA and AC components. In contrast, individual AA concentrations increased in the transition to the postprandial state.
Formal Description
Interaction-ID: 33145

environment

feeding after fasting

decreases_quantity of

drug/chemical compound

Palmitic acid

in blood plasma
Drugbank entries Show/Hide entries for
Comment Using PCA to analyze changes in the fasting-to-postprandial difference (FPPD), we identified single components for FPPD for each of the major analyte modules, free fatty acids FFA, acylcarnitines AC, and amino acids AA, with eigenvalues of 6.37, 8.67, and 7.88 respectively, explaining 80%, 20% and 53% of the variance in the component. At the initial assessment, individual FFA and AC metabolites generally decreased from fasting to the postprandial state, particularly those that loaded heavily as part of the FFA and AC components. In contrast, individual AA concentrations increased in the transition to the postprandial state.
Formal Description
Interaction-ID: 33146

environment

feeding after fasting

decreases_quantity of

drug/chemical compound

alpha-Linolenic acid

in blood plasma
Drugbank entries Show/Hide entries for
Comment Using PCA to analyze changes in the fasting-to-postprandial difference (FPPD), we identified single components for FPPD for each of the major analyte modules, free fatty acids FFA, acylcarnitines AC, and amino acids AA, with eigenvalues of 6.37, 8.67, and 7.88 respectively, explaining 80%, 20% and 53% of the variance in the component. At the initial assessment, individual FFA and AC metabolites generally decreased from fasting to the postprandial state, particularly those that loaded heavily as part of the FFA and AC components. In contrast, individual AA concentrations increased in the transition to the postprandial state.
Formal Description
Interaction-ID: 33147

environment

feeding after fasting

decreases_quantity of

drug/chemical compound

Linoleic acid

in blood plasma
Comment Using PCA to analyze changes in the fasting-to-postprandial difference (FPPD), we identified single components for FPPD for each of the major analyte modules, free fatty acids FFA, acylcarnitines AC, and amino acids AA, with eigenvalues of 6.37, 8.67, and 7.88 respectively, explaining 80%, 20% and 53% of the variance in the component. At the initial assessment, individual FFA and AC metabolites generally decreased from fasting to the postprandial state, particularly those that loaded heavily as part of the FFA and AC components. In contrast, individual AA concentrations increased in the transition to the postprandial state.
Formal Description
Interaction-ID: 33148

environment

feeding after fasting

decreases_quantity of

drug/chemical compound

Oleic acid

in blood plasma
Drugbank entries Show/Hide entries for
Comment Using PCA to analyze changes in the fasting-to-postprandial difference (FPPD), we identified single components for FPPD for each of the major analyte modules, free fatty acids FFA, acylcarnitines AC, and amino acids AA, with eigenvalues of 6.37, 8.67, and 7.88 respectively, explaining 80%, 20% and 53% of the variance in the component. At the initial assessment, individual FFA and AC metabolites generally decreased from fasting to the postprandial state, particularly those that loaded heavily as part of the FFA and AC components. In contrast, individual AA concentrations increased in the transition to the postprandial state.
Formal Description
Interaction-ID: 33149

environment

feeding after fasting

decreases_quantity of

drug/chemical compound

Stearic acid

in blood plasma
Drugbank entries Show/Hide entries for
Comment Using PCA to analyze changes in the fasting-to-postprandial difference (FPPD), we identified single components for FPPD for each of the major analyte modules, free fatty acids FFA, acylcarnitines AC, and amino acids AA, with eigenvalues of 6.37, 8.67, and 7.88 respectively, explaining 80%, 20% and 53% of the variance in the component. At the initial assessment, individual FFA and AC metabolites generally decreased from fasting to the postprandial state, particularly those that loaded heavily as part of the FFA and AC components. In contrast, individual AA concentrations increased in the transition to the postprandial state.
Formal Description
Interaction-ID: 33151

environment

feeding after fasting

decreases_quantity of

drug/chemical compound

Arachidonic acid

in blood plasma
Drugbank entries Show/Hide entries for
Comment Using PCA to analyze changes in the fasting-to-postprandial difference (FPPD), we identified single components for FPPD for each of the major analyte modules, free fatty acids FFA, acylcarnitines AC, and amino acids AA, with eigenvalues of 6.37, 8.67, and 7.88 respectively, explaining 80%, 20% and 53% of the variance in the component. At the initial assessment, individual FFA and AC metabolites generally decreased from fasting to the postprandial state, particularly those that loaded heavily as part of the FFA and AC components. In contrast, individual AA concentrations increased in the transition to the postprandial state.
Formal Description
Interaction-ID: 33152

environment

feeding after fasting

decreases_quantity of

drug/chemical compound

Octanoylcarnitine

in blood plasma
Comment Using PCA to analyze changes in the fasting-to-postprandial difference (FPPD), we identified single components for FPPD for each of the major analyte modules, free fatty acids FFA, acylcarnitines AC, and amino acids AA, with eigenvalues of 6.37, 8.67, and 7.88 respectively, explaining 80%, 20% and 53% of the variance in the component. At the initial assessment, individual FFA and AC metabolites generally decreased from fasting to the postprandial state, particularly those that loaded heavily as part of the FFA and AC components. In contrast, individual AA concentrations increased in the transition to the postprandial state.
Formal Description
Interaction-ID: 33153

environment

feeding after fasting

decreases_quantity of

drug/chemical compound

Adipoylcarnitine

in blood plasma
Comment Using PCA to analyze changes in the fasting-to-postprandial difference (FPPD), we identified single components for FPPD for each of the major analyte modules, free fatty acids FFA, acylcarnitines AC, and amino acids AA, with eigenvalues of 6.37, 8.67, and 7.88 respectively, explaining 80%, 20% and 53% of the variance in the component. At the initial assessment, individual FFA and AC metabolites generally decreased from fasting to the postprandial state, particularly those that loaded heavily as part of the FFA and AC components. In contrast, individual AA concentrations increased in the transition to the postprandial state.
Formal Description
Interaction-ID: 33154

environment

feeding after fasting

decreases_quantity of

drug/chemical compound

Acylcarnitine C10:1

in blood plasma
Comment Using PCA to analyze changes in the fasting-to-postprandial difference (FPPD), we identified single components for FPPD for each of the major analyte modules, free fatty acids FFA, acylcarnitines AC, and amino acids AA, with eigenvalues of 6.37, 8.67, and 7.88 respectively, explaining 80%, 20% and 53% of the variance in the component. At the initial assessment, individual FFA and AC metabolites generally decreased from fasting to the postprandial state, particularly those that loaded heavily as part of the FFA and AC components. In contrast, individual AA concentrations increased in the transition to the postprandial state.
Formal Description
Interaction-ID: 33155

environment

feeding after fasting

decreases_quantity of

drug/chemical compound

Decanoylcarnitine

in blood plasma
Comment Using PCA to analyze changes in the fasting-to-postprandial difference (FPPD), we identified single components for FPPD for each of the major analyte modules, free fatty acids FFA, acylcarnitines AC, and amino acids AA, with eigenvalues of 6.37, 8.67, and 7.88 respectively, explaining 80%, 20% and 53% of the variance in the component. At the initial assessment, individual FFA and AC metabolites generally decreased from fasting to the postprandial state, particularly those that loaded heavily as part of the FFA and AC components. In contrast, individual AA concentrations increased in the transition to the postprandial state.
Formal Description
Interaction-ID: 33157

environment

feeding after fasting

decreases_quantity of

drug/chemical compound

Suberoylcarnitine/3-Hydroxydecanoylcarnitine

in blood plasma
Comment Using PCA to analyze changes in the fasting-to-postprandial difference (FPPD), we identified single components for FPPD for each of the major analyte modules, free fatty acids FFA, acylcarnitines AC, and amino acids AA, with eigenvalues of 6.37, 8.67, and 7.88 respectively, explaining 80%, 20% and 53% of the variance in the component. At the initial assessment, individual FFA and AC metabolites generally decreased from fasting to the postprandial state, particularly those that loaded heavily as part of the FFA and AC components. In contrast, individual AA concentrations increased in the transition to the postprandial state.
Formal Description
Interaction-ID: 33158

environment

feeding after fasting

decreases_quantity of

drug/chemical compound

Acylcarnitine C12:1

in blood plasma
Comment Using PCA to analyze changes in the fasting-to-postprandial difference (FPPD), we identified single components for FPPD for each of the major analyte modules, free fatty acids FFA, acylcarnitines AC, and amino acids AA, with eigenvalues of 6.37, 8.67, and 7.88 respectively, explaining 80%, 20% and 53% of the variance in the component. At the initial assessment, individual FFA and AC metabolites generally decreased from fasting to the postprandial state, particularly those that loaded heavily as part of the FFA and AC components. In contrast, individual AA concentrations increased in the transition to the postprandial state.
Formal Description
Interaction-ID: 33159

environment

feeding after fasting

decreases_quantity of

drug/chemical compound

Lauroylcarnitine

in blood plasma
Comment Using PCA to analyze changes in the fasting-to-postprandial difference (FPPD), we identified single components for FPPD for each of the major analyte modules, free fatty acids FFA, acylcarnitines AC, and amino acids AA, with eigenvalues of 6.37, 8.67, and 7.88 respectively, explaining 80%, 20% and 53% of the variance in the component. At the initial assessment, individual FFA and AC metabolites generally decreased from fasting to the postprandial state, particularly those that loaded heavily as part of the FFA and AC components. In contrast, individual AA concentrations increased in the transition to the postprandial state.
Formal Description
Interaction-ID: 33161

environment

feeding after fasting

decreases_quantity of

drug/chemical compound

Sebacoylcarnitine/3-Hydroxydodecanoylcarnitine

in blood plasma
Comment Using PCA to analyze changes in the fasting-to-postprandial difference (FPPD), we identified single components for FPPD for each of the major analyte modules, free fatty acids FFA, acylcarnitines AC, and amino acids AA, with eigenvalues of 6.37, 8.67, and 7.88 respectively, explaining 80%, 20% and 53% of the variance in the component. At the initial assessment, individual FFA and AC metabolites generally decreased from fasting to the postprandial state, particularly those that loaded heavily as part of the FFA and AC components. In contrast, individual AA concentrations increased in the transition to the postprandial state.
Formal Description
Interaction-ID: 33162

environment

feeding after fasting

decreases_quantity of

drug/chemical compound

Acylcarnitine C14:2

in blood plasma
Comment Using PCA to analyze changes in the fasting-to-postprandial difference (FPPD), we identified single components for FPPD for each of the major analyte modules, free fatty acids FFA, acylcarnitines AC, and amino acids AA, with eigenvalues of 6.37, 8.67, and 7.88 respectively, explaining 80%, 20% and 53% of the variance in the component. At the initial assessment, individual FFA and AC metabolites generally decreased from fasting to the postprandial state, particularly those that loaded heavily as part of the FFA and AC components. In contrast, individual AA concentrations increased in the transition to the postprandial state.
Formal Description
Interaction-ID: 33163

environment

feeding after fasting

decreases_quantity of

drug/chemical compound

Acylcarnitine C14:1

in blood plasma
Comment Using PCA to analyze changes in the fasting-to-postprandial difference (FPPD), we identified single components for FPPD for each of the major analyte modules, free fatty acids FFA, acylcarnitines AC, and amino acids AA, with eigenvalues of 6.37, 8.67, and 7.88 respectively, explaining 80%, 20% and 53% of the variance in the component. At the initial assessment, individual FFA and AC metabolites generally decreased from fasting to the postprandial state, particularly those that loaded heavily as part of the FFA and AC components. In contrast, individual AA concentrations increased in the transition to the postprandial state.
Formal Description
Interaction-ID: 33164

environment

feeding after fasting

decreases_quantity of

drug/chemical compound

Palmitoylcarnitine

in blood plasma
Comment Using PCA to analyze changes in the fasting-to-postprandial difference (FPPD), we identified single components for FPPD for each of the major analyte modules, free fatty acids FFA, acylcarnitines AC, and amino acids AA, with eigenvalues of 6.37, 8.67, and 7.88 respectively, explaining 80%, 20% and 53% of the variance in the component. At the initial assessment, individual FFA and AC metabolites generally decreased from fasting to the postprandial state, particularly those that loaded heavily as part of the FFA and AC components. In contrast, individual AA concentrations increased in the transition to the postprandial state.
Formal Description
Interaction-ID: 33165

environment

feeding after fasting

decreases_quantity of

drug/chemical compound

Acylcarnitine C18:2

in blood plasma
Comment Using PCA to analyze changes in the fasting-to-postprandial difference (FPPD), we identified single components for FPPD for each of the major analyte modules, free fatty acids FFA, acylcarnitines AC, and amino acids AA, with eigenvalues of 6.37, 8.67, and 7.88 respectively, explaining 80%, 20% and 53% of the variance in the component. At the initial assessment, individual FFA and AC metabolites generally decreased from fasting to the postprandial state, particularly those that loaded heavily as part of the FFA and AC components. In contrast, individual AA concentrations increased in the transition to the postprandial state.
Formal Description
Interaction-ID: 33166

environment

feeding after fasting

decreases_quantity of

drug/chemical compound

Acylcarnitine C18:1

in blood plasma
Comment Using PCA to analyze changes in the fasting-to-postprandial difference (FPPD), we identified single components for FPPD for each of the major analyte modules, free fatty acids FFA, acylcarnitines AC, and amino acids AA, with eigenvalues of 6.37, 8.67, and 7.88 respectively, explaining 80%, 20% and 53% of the variance in the component. At the initial assessment, individual FFA and AC metabolites generally decreased from fasting to the postprandial state, particularly those that loaded heavily as part of the FFA and AC components. In contrast, individual AA concentrations increased in the transition to the postprandial state.
Formal Description
Interaction-ID: 33167

environment

feeding after fasting

decreases_quantity of

drug/chemical compound

Acylcarnitine C8:1-DC

in blood plasma
Comment Using PCA to analyze changes in the fasting-to-postprandial difference (FPPD), we identified single components for FPPD for each of the major analyte modules, free fatty acids FFA, acylcarnitines AC, and amino acids AA, with eigenvalues of 6.37, 8.67, and 7.88 respectively, explaining 80%, 20% and 53% of the variance in the component. At the initial assessment, individual FFA and AC metabolites generally decreased from fasting to the postprandial state, particularly those that loaded heavily as part of the FFA and AC components. In contrast, individual AA concentrations increased in the transition to the postprandial state.
Formal Description
Interaction-ID: 33168

environment

feeding after fasting

decreases_quantity of

drug/chemical compound

Acylcarnitine C16:2

in blood plasma
Comment Using PCA to analyze changes in the fasting-to-postprandial difference (FPPD), we identified single components for FPPD for each of the major analyte modules, free fatty acids FFA, acylcarnitines AC, and amino acids AA, with eigenvalues of 6.37, 8.67, and 7.88 respectively, explaining 80%, 20% and 53% of the variance in the component. At the initial assessment, individual FFA and AC metabolites generally decreased from fasting to the postprandial state, particularly those that loaded heavily as part of the FFA and AC components. In contrast, individual AA concentrations increased in the transition to the postprandial state.
Formal Description
Interaction-ID: 33169

environment

feeding after fasting

decreases_quantity of

drug/chemical compound

Acylcarnitine C16:1

in blood plasma
Comment Using PCA to analyze changes in the fasting-to-postprandial difference (FPPD), we identified single components for FPPD for each of the major analyte modules, free fatty acids FFA, acylcarnitines AC, and amino acids AA, with eigenvalues of 6.37, 8.67, and 7.88 respectively, explaining 80%, 20% and 53% of the variance in the component. At the initial assessment, individual FFA and AC metabolites generally decreased from fasting to the postprandial state, particularly those that loaded heavily as part of the FFA and AC components. In contrast, individual AA concentrations increased in the transition to the postprandial state.
Formal Description
Interaction-ID: 33170

environment

feeding after fasting

decreases_quantity of

drug/chemical compound

Acylcarnitine C20:4

in blood plasma
Comment Using PCA to analyze changes in the fasting-to-postprandial difference (FPPD), we identified single components for FPPD for each of the major analyte modules, free fatty acids FFA, acylcarnitines AC, and amino acids AA, with eigenvalues of 6.37, 8.67, and 7.88 respectively, explaining 80%, 20% and 53% of the variance in the component. At the initial assessment, individual FFA and AC metabolites generally decreased from fasting to the postprandial state, particularly those that loaded heavily as part of the FFA and AC components. In contrast, individual AA concentrations increased in the transition to the postprandial state.
Formal Description
Interaction-ID: 33171

environment

feeding after fasting

increases_quantity of

drug/chemical compound

Glycine

in blood plasma
Drugbank entries Show/Hide entries for
Comment Using PCA to analyze changes in the fasting-to-postprandial difference (FPPD), we identified single components for FPPD for each of the major analyte modules, free fatty acids FFA, acylcarnitines AC, and amino acids AA, with eigenvalues of 6.37, 8.67, and 7.88 respectively, explaining 80%, 20% and 53% of the variance in the component. At the initial assessment, individual FFA and AC metabolites generally decreased from fasting to the postprandial state, particularly those that loaded heavily as part of the FFA and AC components. In contrast, individual AA concentrations increased in the transition to the postprandial state.
Formal Description
Interaction-ID: 33172

environment

feeding after fasting

increases_quantity of

drug/chemical compound

Alanine

in blood plasma
Comment Using PCA to analyze changes in the fasting-to-postprandial difference (FPPD), we identified single components for FPPD for each of the major analyte modules, free fatty acids FFA, acylcarnitines AC, and amino acids AA, with eigenvalues of 6.37, 8.67, and 7.88 respectively, explaining 80%, 20% and 53% of the variance in the component. At the initial assessment, individual FFA and AC metabolites generally decreased from fasting to the postprandial state, particularly those that loaded heavily as part of the FFA and AC components. In contrast, individual AA concentrations increased in the transition to the postprandial state.
Formal Description
Interaction-ID: 33173

environment

feeding after fasting

increases_quantity of

drug/chemical compound

Serine

in blood plasma
Comment Using PCA to analyze changes in the fasting-to-postprandial difference (FPPD), we identified single components for FPPD for each of the major analyte modules, free fatty acids FFA, acylcarnitines AC, and amino acids AA, with eigenvalues of 6.37, 8.67, and 7.88 respectively, explaining 80%, 20% and 53% of the variance in the component. At the initial assessment, individual FFA and AC metabolites generally decreased from fasting to the postprandial state, particularly those that loaded heavily as part of the FFA and AC components. In contrast, individual AA concentrations increased in the transition to the postprandial state.
Formal Description
Interaction-ID: 33174

environment

feeding after fasting

increases_quantity of

drug/chemical compound

Proline

in blood plasma
Comment Using PCA to analyze changes in the fasting-to-postprandial difference (FPPD), we identified single components for FPPD for each of the major analyte modules, free fatty acids FFA, acylcarnitines AC, and amino acids AA, with eigenvalues of 6.37, 8.67, and 7.88 respectively, explaining 80%, 20% and 53% of the variance in the component. At the initial assessment, individual FFA and AC metabolites generally decreased from fasting to the postprandial state, particularly those that loaded heavily as part of the FFA and AC components. In contrast, individual AA concentrations increased in the transition to the postprandial state.
Formal Description
Interaction-ID: 33175

environment

feeding after fasting

increases_quantity of

drug/chemical compound

Valine

in blood plasma
Comment Using PCA to analyze changes in the fasting-to-postprandial difference (FPPD), we identified single components for FPPD for each of the major analyte modules, free fatty acids FFA, acylcarnitines AC, and amino acids AA, with eigenvalues of 6.37, 8.67, and 7.88 respectively, explaining 80%, 20% and 53% of the variance in the component. At the initial assessment, individual FFA and AC metabolites generally decreased from fasting to the postprandial state, particularly those that loaded heavily as part of the FFA and AC components. In contrast, individual AA concentrations increased in the transition to the postprandial state.
Formal Description
Interaction-ID: 33176

environment

feeding after fasting

increases_quantity of

drug/chemical compound

Leucine/Isoleucine

in blood plasma
Comment Using PCA to analyze changes in the fasting-to-postprandial difference (FPPD), we identified single components for FPPD for each of the major analyte modules, free fatty acids FFA, acylcarnitines AC, and amino acids AA, with eigenvalues of 6.37, 8.67, and 7.88 respectively, explaining 80%, 20% and 53% of the variance in the component. At the initial assessment, individual FFA and AC metabolites generally decreased from fasting to the postprandial state, particularly those that loaded heavily as part of the FFA and AC components. In contrast, individual AA concentrations increased in the transition to the postprandial state.
Formal Description
Interaction-ID: 33177

environment

feeding after fasting

increases_quantity of

drug/chemical compound

Methionine

in blood plasma
Comment Using PCA to analyze changes in the fasting-to-postprandial difference (FPPD), we identified single components for FPPD for each of the major analyte modules, free fatty acids FFA, acylcarnitines AC, and amino acids AA, with eigenvalues of 6.37, 8.67, and 7.88 respectively, explaining 80%, 20% and 53% of the variance in the component. At the initial assessment, individual FFA and AC metabolites generally decreased from fasting to the postprandial state, particularly those that loaded heavily as part of the FFA and AC components. In contrast, individual AA concentrations increased in the transition to the postprandial state.
Formal Description
Interaction-ID: 33178

environment

feeding after fasting

increases_quantity of

drug/chemical compound

Histidine

in blood plasma
Comment Using PCA to analyze changes in the fasting-to-postprandial difference (FPPD), we identified single components for FPPD for each of the major analyte modules, free fatty acids FFA, acylcarnitines AC, and amino acids AA, with eigenvalues of 6.37, 8.67, and 7.88 respectively, explaining 80%, 20% and 53% of the variance in the component. At the initial assessment, individual FFA and AC metabolites generally decreased from fasting to the postprandial state, particularly those that loaded heavily as part of the FFA and AC components. In contrast, individual AA concentrations increased in the transition to the postprandial state.
Formal Description
Interaction-ID: 33179

environment

feeding after fasting

increases_quantity of

drug/chemical compound

Phenylalanine

in blood plasma
Comment Using PCA to analyze changes in the fasting-to-postprandial difference (FPPD), we identified single components for FPPD for each of the major analyte modules, free fatty acids FFA, acylcarnitines AC, and amino acids AA, with eigenvalues of 6.37, 8.67, and 7.88 respectively, explaining 80%, 20% and 53% of the variance in the component. At the initial assessment, individual FFA and AC metabolites generally decreased from fasting to the postprandial state, particularly those that loaded heavily as part of the FFA and AC components. In contrast, individual AA concentrations increased in the transition to the postprandial state.
Formal Description
Interaction-ID: 33180

environment

feeding after fasting

increases_quantity of

drug/chemical compound

Tyrosine

in blood plasma
Comment Using PCA to analyze changes in the fasting-to-postprandial difference (FPPD), we identified single components for FPPD for each of the major analyte modules, free fatty acids FFA, acylcarnitines AC, and amino acids AA, with eigenvalues of 6.37, 8.67, and 7.88 respectively, explaining 80%, 20% and 53% of the variance in the component. At the initial assessment, individual FFA and AC metabolites generally decreased from fasting to the postprandial state, particularly those that loaded heavily as part of the FFA and AC components. In contrast, individual AA concentrations increased in the transition to the postprandial state.
Formal Description
Interaction-ID: 33181

environment

feeding after fasting

increases_quantity of

drug/chemical compound

Asparagine/Aspartate

in blood plasma
Comment Using PCA to analyze changes in the fasting-to-postprandial difference (FPPD), we identified single components for FPPD for each of the major analyte modules, free fatty acids FFA, acylcarnitines AC, and amino acids AA, with eigenvalues of 6.37, 8.67, and 7.88 respectively, explaining 80%, 20% and 53% of the variance in the component. At the initial assessment, individual FFA and AC metabolites generally decreased from fasting to the postprandial state, particularly those that loaded heavily as part of the FFA and AC components. In contrast, individual AA concentrations increased in the transition to the postprandial state.
Formal Description
Interaction-ID: 33182

environment

feeding after fasting

increases_quantity of

drug/chemical compound

Ornithine

in blood plasma
Comment Using PCA to analyze changes in the fasting-to-postprandial difference (FPPD), we identified single components for FPPD for each of the major analyte modules, free fatty acids FFA, acylcarnitines AC, and amino acids AA, with eigenvalues of 6.37, 8.67, and 7.88 respectively, explaining 80%, 20% and 53% of the variance in the component. At the initial assessment, individual FFA and AC metabolites generally decreased from fasting to the postprandial state, particularly those that loaded heavily as part of the FFA and AC components. In contrast, individual AA concentrations increased in the transition to the postprandial state.
Formal Description
Interaction-ID: 33183

environment

feeding after fasting

increases_quantity of

drug/chemical compound

Arginine

in blood plasma
Comment The caloric restriction (CR) intervention significantly increased the fasting-to-postprandial difference (FPPD) in circulating acylcarnitines (AC) and free fatty acids (FFA). Moreover the study showed that increased FPPD for both AC and AA were related to greater insulin sensitivity.
Formal Description
Interaction-ID: 33184

environment

calorie restriction

affects_activity of

phenotype

abnormal circulating free fatty acids level

Comment The caloric restriction (CR) intervention significantly increased the fasting-to-postprandial difference (FPPD) in circulating acylcarnitines (AC) and free fatty acids (FFA). Moreover the study showed that increased FPPD for both AC and AA were related to greater insulin sensitivity.
Formal Description
Interaction-ID: 33185
Comment The caloric restriction (CR) intervention significantly increased the fasting-to-postprandial difference (FPPD) in circulating acylcarnitines (AC) and free fatty acids (FFA). Moreover the study showed that increased FPPD for both AC and AA were related to greater insulin sensitivity.
Formal Description
Interaction-ID: 33186

environment

calorie restriction

affects_activity of

phenotype

abnormal circulating acylcarnitine level

Comment The caloric restriction (CR) intervention significantly increased the fasting-to-postprandial difference (FPPD) in circulating acylcarnitines (AC) and free fatty acids (FFA). Moreover the study showed that increased FPPD for both AC and AA were related to greater insulin sensitivity.
Formal Description
Interaction-ID: 33187

phenotype

abnormal circulating acylcarnitine level

affects_activity of

phenotype

increased insulin sensitivity