CIDeRplusGeneral Information:
| Id: | 3,560 |
| Diseases: |
Diabetes mellitus, type II
- [OMIM]
Insulin resistance Obesity - [OMIM] |
| Homo sapiens | |
| article | |
| Reference: | Huffman KM et al.(2011) Exercise-induced changes in metabolic intermediates, hormones, and inflammatory markers associated with improvements in insulin sensitivity Diabetes Care 1: 174-176 [PMID: 20921216] |
Interaction Information:
| Comment | Examination of mean baseline to posttraining changes in clinical, metabolic, and inflammatory analytes showed significant changes for arachidoyl carnitine (C20), leptin, and monocyte chemoattractant protein 1. |
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Formal Description Interaction-ID: 33068 |
environment exercise decreases_quantity of drug/chemical compound Arachidoylcarnitine |
| Comment | Examination of mean baseline to posttraining changes in clinical, metabolic, and inflammatory analytes showed significant changes for arachidoyl carnitine (C20), leptin, and monocyte chemoattractant protein 1. |
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Formal Description Interaction-ID: 33134 |
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| Comment | Examination of mean baseline to posttraining changes in clinical, metabolic, and inflammatory analytes showed significant changes for arachidoyl carnitine (C20), leptin, and monocyte chemoattractant protein 1. |
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Formal Description Interaction-ID: 33135 |
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| Drugbank entries | Show/Hide entries for CCL2 |
| Comment | Improvements in insulin sensitivity (SI) after 6 months of exercise training were associated with reductions in free fatty acids and byproducts of fatty acid oxidation, and with increases in glycine, proline, and C20, acylcarnitine and C18:1, hydroxyacylcarnitine. These associations were independent of other known contributors to SI (age, sex, and waist circumference). |
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Formal Description Interaction-ID: 33136 |
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| Comment | Improvements in insulin sensitivity (SI) after 6 months of exercise training were associated with reductions in free fatty acids and byproducts of fatty acid oxidation, and with increases in glycine, proline. These associations were independent of other known contributors to SI (age, sex, and waist circumference). |
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Formal Description Interaction-ID: 33137 |
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| Comment | Improvements in insulin sensitivity (SI) after 6 months of exercise training were associated with reductions in free fatty acids and byproducts of fatty acid oxidation, and with increases in glycine, proline. These associations were independent of other known contributors to SI (age, sex, and waist circumference). |
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Formal Description Interaction-ID: 33138 |
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| Drugbank entries | Show/Hide entries for |
| Comment | Improvements in insulin sensitivity (SI) after 6 months of exercise training were associated with reductions in free fatty acids and byproducts of fatty acid oxidation, and with increases in glycine, proline. These associations were independent of other known contributors to SI (age, sex, and waist circumference). |
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Formal Description Interaction-ID: 33139 |
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| Comment | The findings suggest that by providing an increased energy demand, exercise training either promotes more efficient mitochondrial function and beta-oxidation or reduces lipolysis via enhanced insulin action. Consistent with the former (improved mitochondrial efficiency) is the strong effect on glycine, for which improvements in insulin sensitivity were associated with recovery of glycine concentrations. Glycine conjugates, specifically acylglycines, are used as a means to purge excess metabolic fuels via the urine. Thus, one might expect that in an attempt to relieve overloaded, inefficient mitochondria, glycine-adduct formation depletes the glycine pool as evidenced by our prior reports of crosssectional associations between lower glycine concentrations and poorer insulin sensitivity in this population. The recovery of glycine in exercising subjects may therefore serve as an index of a return of metabolic efficiency and clearing of incompletely oxidized substrates from the mitochondria. |
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Formal Description Interaction-ID: 33140 |
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| Comment | The findings suggest that by providing an increased energy demand, exercise training either promotes more efficient mitochondrial function and beta-oxidation or reduces lipolysis via enhanced insulin action. Consistent with the former (improved mitochondrial efficiency) is the strong effect on glycine, for which improvements in insulin sensitivity were associated with recovery of glycine concentrations. Glycine conjugates, specifically acylglycines, are used as a means to purge excess metabolic fuels via the urine. Thus, one might expect that in an attempt to relieve overloaded, inefficient mitochondria, glycine-adduct formation depletes the glycine pool as evidenced by our prior reports of crosssectional associations between lower glycine concentrations and poorer insulin sensitivity in this population. The recovery of glycine in exercising subjects may therefore serve as an index of a return of metabolic efficiency and clearing of incompletely oxidized substrates from the mitochondria. |
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Formal Description Interaction-ID: 33141 |
environment exercise decreases_activity of process incomplete fatty acid beta-oxidation |
| Comment | The findings suggest that by providing an increased energy demand, exercise training either promotes more efficient mitochondrial function and beta-oxidation or reduces lipolysis via enhanced insulin action. Consistent with the former (improved mitochondrial efficiency) is the strong effect on glycine, for which improvements in insulin sensitivity were associated with recovery of glycine concentrations. Glycine conjugates, specifically acylglycines, are used as a means to purge excess metabolic fuels via the urine. Thus, one might expect that in an attempt to relieve overloaded, inefficient mitochondria, glycine-adduct formation depletes the glycine pool as evidenced by our prior reports of crosssectional associations between lower glycine concentrations and poorer insulin sensitivity in this population. The recovery of glycine in exercising subjects may therefore serve as an index of a return of metabolic efficiency and clearing of incompletely oxidized substrates from the mitochondria. |
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Formal Description Interaction-ID: 33142 |
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