General Information:

Id: 350 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Mus musculus
BTO:0000312 motoneuron
article
Reference: Raoul C et al.(2002) Motoneuron death triggered by a specific pathway downstream of Fas. potentiation by ALS-linked SOD1 mutations. Neuron 35: 1067-1083 [PMID: 12354397]

Interaction Information:

Comment Production of NO by nNOS is necessary for Fas to exert its killing effect in motoneurons.
Formal Description
Interaction-ID: 1397

drug/chemical compound

NO

increases_activity of

phenotype

motor neuron degeneration

in Fas-activated motoneurons