CIDeRplusGeneral Information:
| Id: | 3,438 |
| Diseases: |
Diabetes mellitus, type II
- [OMIM]
Insulin resistance Metabolic syndrome Obesity - [OMIM] |
| Rattus norvegicus | |
| male | |
| article | |
| Reference: | Sampey BP et al.(2012) Metabolomic profiling reveals mitochondrial-derived lipid biomarkers that drive obesity-associated inflammation PLoS ONE 7 [PMID: 22701716] |
Interaction Information:
| Comment | The influence of Cafeteria diets (CAF) consisting of nutrient poor human junk food was investigated. Supervised cluster analysis was performed to elucidate patterns of serum metabolic changes in CAF vs. SC-fed animals. This cluster analysis implicates upregulation of many NEFAs and acylcarnitine species with downregulation of several amino acids, arachidonoyl carnitine (C20:4), and short chain acylcarnitines in CAF-fed rats. Accumulation of acylcarnitines is indicative of inefficient beta-oxidation and mitochondrial dysfunction. |
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Formal Description Interaction-ID: 31967 |
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| Drugbank entries | Show/Hide entries for |
| Comment | The influence of Cafeteria diets (CAF) consisting of nutrient poor human junk food was investigated. Supervised cluster analysis was performed to elucidate patterns of serum metabolic changes in CAF vs. SC-fed animals. This cluster analysis implicates upregulation of many NEFAs and acylcarnitine species with downregulation of several amino acids, arachidonoyl carnitine (C20:4), and short chain acylcarnitines in CAF-fed rats. Accumulation of acylcarnitines is indicative of inefficient beta-oxidation and mitochondrial dysfunction. |
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Formal Description Interaction-ID: 31976 |
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| Comment | The influence of Cafeteria diets (CAF) consisting of nutrient poor human junk food was investigated. Supervised cluster analysis was performed to elucidate patterns of serum metabolic changes in CAF vs. SC-fed animals. This cluster analysis implicates upregulation of many NEFAs and acylcarnitine species with downregulation of several amino acids, arachidonoyl carnitine (C20:4), and short chain acylcarnitines in CAF-fed rats. Accumulation of acylcarnitines is indicative of inefficient beta-oxidation and mitochondrial dysfunction. |
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Formal Description Interaction-ID: 31978 |
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| Comment | The influence of Cafeteria diets (CAF) consisting of nutrient poor human junk food was investigated. Supervised cluster analysis was performed to elucidate patterns of serum metabolic changes in CAF vs. SC-fed animals. This cluster analysis implicates upregulation of many NEFAs and acylcarnitine species with downregulation of several amino acids, arachidonoyl carnitine (C20:4), and short chain acylcarnitines in CAF-fed rats. Accumulation of acylcarnitines is indicative of inefficient beta-oxidation and mitochondrial dysfunction. |
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Formal Description Interaction-ID: 31979 |
environment cafeteria diet decreases_quantity of drug/chemical compound Leucine/Isoleucine |
| Comment | The influence of Cafeteria diets (CAF) consisting of nutrient poor human junk food was investigated. Supervised cluster analysis was performed to elucidate patterns of serum metabolic changes in CAF vs. SC-fed animals. This cluster analysis implicates upregulation of many NEFAs and acylcarnitine species with downregulation of several amino acids, arachidonoyl carnitine (C20:4), and short chain acylcarnitines in CAF-fed rats. Accumulation of acylcarnitines is indicative of inefficient beta-oxidation and mitochondrial dysfunction. |
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Formal Description Interaction-ID: 31980 |
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| Comment | The influence of Cafeteria diets (CAF) consisting of nutrient poor human junk food was investigated. Supervised cluster analysis was performed to elucidate patterns of serum metabolic changes in CAF vs. SC-fed animals. This cluster analysis implicates upregulation of many NEFAs and acylcarnitine species with downregulation of several amino acids, arachidonoyl carnitine (C20:4), and short chain acylcarnitines in CAF-fed rats. Accumulation of acylcarnitines is indicative of inefficient beta-oxidation and mitochondrial dysfunction. |
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Formal Description Interaction-ID: 31981 |
environment cafeteria diet increases_quantity of drug/chemical compound Asparagine/Aspartate |
| Comment | The influence of Cafeteria diets (CAF) consisting of nutrient poor human junk food was investigated. Supervised cluster analysis was performed to elucidate patterns of serum metabolic changes in CAF vs. SC-fed animals. This cluster analysis implicates upregulation of many NEFAs and acylcarnitine species with downregulation of several amino acids, arachidonoyl carnitine (C20:4), and short chain acylcarnitines in CAF-fed rats. Accumulation of acylcarnitines is indicative of inefficient beta-oxidation and mitochondrial dysfunction. |
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Formal Description Interaction-ID: 31982 |
environment cafeteria diet increases_quantity of drug/chemical compound Glutamine/Glutamate |
| Comment | The influence of Cafeteria diets (CAF) consisting of nutrient poor human junk food was investigated. Supervised cluster analysis was performed to elucidate patterns of serum metabolic changes in CAF vs. SC-fed animals. This cluster analysis implicates upregulation of many NEFAs and acylcarnitine species with downregulation of several amino acids, arachidonoyl carnitine (C20:4), and short chain acylcarnitines in CAF-fed rats. Accumulation of acylcarnitines is indicative of inefficient beta-oxidation and mitochondrial dysfunction. |
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Formal Description Interaction-ID: 31983 |
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| Comment | The influence of Cafeteria diets (CAF) consisting of nutrient poor human junk food was investigated. Supervised cluster analysis was performed to elucidate patterns of serum metabolic changes in CAF vs. SC-fed animals. This cluster analysis implicates upregulation of many NEFAs and acylcarnitine species with downregulation of several amino acids, arachidonoyl carnitine (C20:4), and short chain acylcarnitines in CAF-fed rats. Accumulation of acylcarnitines is indicative of inefficient beta-oxidation and mitochondrial dysfunction. |
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Formal Description Interaction-ID: 31984 |
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| Comment | The influence of Cafeteria diets (CAF) consisting of nutrient poor human junk food was investigated. Supervised cluster analysis was performed to elucidate patterns of serum metabolic changes in CAF vs. SC-fed animals. This cluster analysis implicates upregulation of many NEFAs and acylcarnitine species with downregulation of several amino acids, arachidonoyl carnitine (C20:4), and short chain acylcarnitines in CAF-fed rats. Accumulation of acylcarnitines is indicative of inefficient beta-oxidation and mitochondrial dysfunction. |
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Formal Description Interaction-ID: 31985 |
environment cafeteria diet affects_quantity of drug/chemical compound Adipoylcarnitine |
| Comment | The influence of Cafeteria diets (CAF) consisting of nutrient poor human junk food was investigated. Supervised cluster analysis was performed to elucidate patterns of serum metabolic changes in CAF vs. SC-fed animals. This cluster analysis implicates upregulation of many NEFAs and acylcarnitine species with downregulation of several amino acids, arachidonoyl carnitine (C20:4), and short chain acylcarnitines in CAF-fed rats. Accumulation of acylcarnitines is indicative of inefficient beta-oxidation and mitochondrial dysfunction. |
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Formal Description Interaction-ID: 31986 |
environment cafeteria diet increases_quantity of drug/chemical compound Acylcarnitine C10:3 |
| Comment | The influence of Cafeteria diets (CAF) consisting of nutrient poor human junk food was investigated. Supervised cluster analysis was performed to elucidate patterns of serum metabolic changes in CAF vs. SC-fed animals. This cluster analysis implicates upregulation of many NEFAs and acylcarnitine species with downregulation of several amino acids, arachidonoyl carnitine (C20:4), and short chain acylcarnitines in CAF-fed rats. Accumulation of acylcarnitines is indicative of inefficient beta-oxidation and mitochondrial dysfunction. |
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Formal Description Interaction-ID: 31987 |
environment cafeteria diet increases_quantity of drug/chemical compound Acylcarnitine C10:1 |
| Comment | The influence of Cafeteria diets (CAF) consisting of nutrient poor human junk food was investigated. Supervised cluster analysis was performed to elucidate patterns of serum metabolic changes in CAF vs. SC-fed animals. This cluster analysis implicates upregulation of many NEFAs and acylcarnitine species with downregulation of several amino acids, arachidonoyl carnitine (C20:4), and short chain acylcarnitines in CAF-fed rats. Accumulation of acylcarnitines is indicative of inefficient beta-oxidation and mitochondrial dysfunction. |
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Formal Description Interaction-ID: 31988 |
environment cafeteria diet increases_quantity of drug/chemical compound Acylcarnitine C12:1 |
| Comment | The influence of Cafeteria diets (CAF) consisting of nutrient poor human junk food was investigated. Supervised cluster analysis was performed to elucidate patterns of serum metabolic changes in CAF vs. SC-fed animals. This cluster analysis implicates upregulation of many NEFAs and acylcarnitine species with downregulation of several amino acids, arachidonoyl carnitine (C20:4), and short chain acylcarnitines in CAF-fed rats. Accumulation of acylcarnitines is indicative of inefficient beta-oxidation and mitochondrial dysfunction. |
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Formal Description Interaction-ID: 31989 |
environment cafeteria diet increases_quantity of drug/chemical compound Lauroylcarnitine |
| Comment | The influence of Cafeteria diets (CAF) consisting of nutrient poor human junk food was investigated. Supervised cluster analysis was performed to elucidate patterns of serum metabolic changes in CAF vs. SC-fed animals. This cluster analysis implicates upregulation of many NEFAs and acylcarnitine species with downregulation of several amino acids, arachidonoyl carnitine (C20:4), and short chain acylcarnitines in CAF-fed rats. Accumulation of acylcarnitines is indicative of inefficient beta-oxidation and mitochondrial dysfunction. |
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Formal Description Interaction-ID: 31990 |
environment cafeteria diet increases_quantity of drug/chemical compound Acylcarnitine C14:1 |
| Comment | The influence of Cafeteria diets (CAF) consisting of nutrient poor human junk food was investigated. Supervised cluster analysis was performed to elucidate patterns of serum metabolic changes in CAF vs. SC-fed animals. This cluster analysis implicates upregulation of many NEFAs and acylcarnitine species with downregulation of several amino acids, arachidonoyl carnitine (C20:4), and short chain acylcarnitines in CAF-fed rats. Accumulation of acylcarnitines is indicative of inefficient beta-oxidation and mitochondrial dysfunction. |
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Formal Description Interaction-ID: 31991 |
environment cafeteria diet increases_quantity of drug/chemical compound Acylcarnitine C16:2 |
| Comment | The influence of Cafeteria diets (CAF) consisting of nutrient poor human junk food was investigated. Supervised cluster analysis was performed to elucidate patterns of serum metabolic changes in CAF vs. SC-fed animals. This cluster analysis implicates upregulation of many NEFAs and acylcarnitine species with downregulation of several amino acids, arachidonoyl carnitine (C20:4), and short chain acylcarnitines in CAF-fed rats. Accumulation of acylcarnitines is indicative of inefficient beta-oxidation and mitochondrial dysfunction. |
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Formal Description Interaction-ID: 31992 |
environment cafeteria diet increases_quantity of drug/chemical compound Acylcarnitine C18:2 |
| Comment | The influence of Cafeteria diets (CAF) consisting of nutrient poor human junk food was investigated. Supervised cluster analysis was performed to elucidate patterns of serum metabolic changes in CAF vs. SC-fed animals. This cluster analysis implicates upregulation of many NEFAs and acylcarnitine species with downregulation of several amino acids, arachidonoyl carnitine (C20:4), and short chain acylcarnitines in CAF-fed rats. Accumulation of acylcarnitines is indicative of inefficient beta-oxidation and mitochondrial dysfunction. |
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Formal Description Interaction-ID: 31993 |
environment cafeteria diet increases_quantity of drug/chemical compound Acylcarnitine C18:1 |
| Comment | The influence of Cafeteria diets (CAF) consisting of nutrient poor human junk food was investigated. Supervised cluster analysis was performed to elucidate patterns of serum metabolic changes in CAF vs. SC-fed animals. This cluster analysis implicates upregulation of many NEFAs and acylcarnitine species with downregulation of several amino acids, arachidonoyl carnitine (C20:4), and short chain acylcarnitines in CAF-fed rats. Accumulation of acylcarnitines is indicative of inefficient beta-oxidation and mitochondrial dysfunction. |
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Formal Description Interaction-ID: 31994 |
environment cafeteria diet increases_quantity of drug/chemical compound Docosanoylcarnitine |
| Comment | The influence of Cafeteria diets (CAF) consisting of nutrient poor human junk food was investigated. Supervised cluster analysis was performed to elucidate patterns of serum metabolic changes in CAF vs. SC-fed animals. This cluster analysis implicates upregulation of many NEFAs and acylcarnitine species with downregulation of several amino acids, arachidonoyl carnitine (C20:4), and short chain acylcarnitines in CAF-fed rats. Accumulation of acylcarnitines is indicative of inefficient beta-oxidation and mitochondrial dysfunction. |
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Formal Description Interaction-ID: 31995 |
environment cafeteria diet increases_activity of process incomplete fatty acid beta-oxidation |
| Comment | The influence of Cafeteria diets (CAF) consisting of nutrient poor human junk food was investigated. Supervised cluster analysis was performed to elucidate patterns of serum metabolic changes in CAF vs. SC-fed animals. This cluster analysis implicates upregulation of many NEFAs and acylcarnitine species with downregulation of several amino acids, arachidonoyl carnitine (C20:4), and short chain acylcarnitines in CAF-fed rats. Accumulation of acylcarnitines is indicative of inefficient beta-oxidation and mitochondrial dysfunction. |
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Formal Description Interaction-ID: 32003 |
environment cafeteria diet decreases_quantity of drug/chemical compound Acylcarnitine C20:4 |
| Comment | After adjustments for multiple comparisons between metabolites and physiologic measures, the elevated molar sum of serum non-esterified fatty acids (NEFA) in CAF-fed obese rats correlated weakly with HOMA-IR, and most strongly with blood glucose and weight gain. |
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Formal Description Interaction-ID: 32004 |
environment cafeteria diet increases_activity of |
| Comment | After adjustments for multiple comparisons between metabolites and physiologic measures, the elevated molar sum of serum non-esterified fatty acids (NEFA) in CAF-fed obese rats correlated weakly with HOMA-IR, and most strongly with blood glucose and weight gain. |
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Formal Description Interaction-ID: 32005 |
increases_activity of disease Insulin resistance |
| Comment | After adjustments for multiple comparisons between metabolites and physiologic measures, the elevated molar sum of serum non-esterified fatty acids (NEFA) in CAF-fed obese rats correlated weakly with HOMA-IR, and most strongly with blood glucose and weight gain. |
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Formal Description Interaction-ID: 32006 |
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| Comment | After adjustments for multiple comparisons between metabolites and physiologic measures, the elevated molar sum of serum non-esterified fatty acids (NEFA) in CAF-fed obese rats correlated weakly with HOMA-IR, and most strongly with blood glucose and weight gain. |
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Formal Description Interaction-ID: 32007 |
increases_activity of phenotype |
| Comment | Among individual serum NEFAs, myristic acid (C14:0) was most significantly correlated with weight gain, glucose, and HOMA-IR. |
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Formal Description Interaction-ID: 32008 |
drug/chemical compound increases_activity of phenotype |
| Drugbank entries | Show/Hide entries for Myristic acid |
| Comment | Among individual serum NEFAs, myristic acid (C14:0) was most significantly correlated with weight gain, glucose, and HOMA-IR. |
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Formal Description Interaction-ID: 32009 |
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| Drugbank entries | Show/Hide entries for Myristic acid |
| Comment | Among individual serum NEFAs, myristic acid (C14:0) was most significantly correlated with weight gain, glucose, and HOMA-IR. |
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Formal Description Interaction-ID: 32013 |
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| Drugbank entries | Show/Hide entries for Myristic acid |
| Comment | Taken together the data suggest, at least in rat models, thresholds may be set including serum levels above 5 microM for myristic acid (C14:0) and 225 microM for NEFAs above which elevated risk of components of Metabolic Syndrome is present. |
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Formal Description Interaction-ID: 32014 |
increases_activity of disease Metabolic syndrome |
| Comment | Serum palmitoleic acid (C16:1), a lipokine associated with improved insulin sensitivity and metabolic status in rodents and patients, was present at high levels in CAF-fed rats, and was positively correlated with poor metabolic status including weight gain, elevated blood glucose and high NEFA levels. |
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Formal Description Interaction-ID: 32015 |
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| Drugbank entries | Show/Hide entries for |
| Comment | Serum palmitoleic acid (C16:1), a lipokine associated with improved insulin sensitivity and metabolic status in rodents and patients, was present at high levels in CAF-fed rats, and was positively correlated with poor metabolic status including weight gain, elevated blood glucose and high NEFA levels. |
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Formal Description Interaction-ID: 32016 |
drug/chemical compound increases_activity of phenotype |
| Drugbank entries | Show/Hide entries for Palmitoleic acid |
| Comment | Serum palmitoleic acid (C16:1), a lipokine associated with improved insulin sensitivity and metabolic status in rodents and patients, was present at high levels in CAF-fed rats, and was positively correlated with poor metabolic status including weight gain, elevated blood glucose and high NEFA levels. |
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Formal Description Interaction-ID: 32017 |
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| Drugbank entries | Show/Hide entries for Palmitoleic acid |
| Comment | Serum palmitoleic acid (C16:1), a lipokine associated with improved insulin sensitivity and metabolic status in rodents and patients, was present at high levels in CAF-fed rats, and was positively correlated with poor metabolic status including weight gain, elevated blood glucose and high NEFA levels. |
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Formal Description Interaction-ID: 32018 |
drug/chemical compound increases_activity of |
| Drugbank entries | Show/Hide entries for Palmitoleic acid |
| Comment | Elevated levels of serum AC derived from myristic acid (myristoyl carnitine, C14-AC) also significantly correlated with markers of poor metabolic status including blood glucose, NEFA, and weight gain. |
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Formal Description Interaction-ID: 32020 |
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| Comment | Elevated levels of serum AC derived from myristic acid (myristoyl carnitine, C14-AC) also significantly correlated with markers of poor metabolic status including blood glucose, NEFA, and weight gain. |
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Formal Description Interaction-ID: 32022 |
drug/chemical compound Tetradecanoylcarnitine increases_activity of phenotype |
| Comment | Elevated levels of serum AC derived from myristic acid (myristoyl carnitine, C14-AC) also significantly correlated with markers of poor metabolic status including blood glucose, NEFA, and weight gain. |
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Formal Description Interaction-ID: 32023 |
drug/chemical compound Tetradecanoylcarnitine increases_activity of |
| Comment | The lauric acid-derived serum acylcarnitine (lauroyl carnitine, C12-AC) was elevated in CAF-fed rat serum and correlated with blood glucose and weight gain. |
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Formal Description Interaction-ID: 32025 |
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| Comment | The lauric acid-derived serum acylcarnitine (lauroyl carnitine, C12-AC) was elevated in CAF-fed rat serum and correlated with blood glucose and weight gain. |
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Formal Description Interaction-ID: 32026 |
drug/chemical compound Lauroylcarnitine increases_activity of phenotype |
| Comment | Alterations in acylcarnitines derived from branched chain amino acid (BCAA) catabolism are reflected by changes in small chain acylcarnitines C3, C4, C5 and related metabolites. Serum propionyl carnitine (C3-AC) was consistently decreased by CAF feeding. |
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Formal Description Interaction-ID: 32027 |
environment cafeteria diet decreases_quantity of drug/chemical compound |
| Comment | Alterations in acylcarnitines derived from branched chain amino acid (BCAA) catabolism are reflected by changes in small chain acylcarnitines C3, C4, C5 and related metabolites. Serum propionyl carnitine (C3-AC) was consistently decreased by CAF feeding. |
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Formal Description Interaction-ID: 32031 |
affects_quantity of drug/chemical compound |
| Comment | After 10 weeks on cafeteria diet, muscle triglyceride content was elevated by two-fold compared to SC-fed rats. |
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Formal Description Interaction-ID: 32034 |
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| Comment | The study showed an accumulation of a subset of muscle acylcarnitines comprised of short, medium and long chain species in CAF-fed rodents compared to SC-fed controls indicative of mitochondrial dysfunction, as was also found in serum. |
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Formal Description Interaction-ID: 32035 |
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| Comment | The study showed an accumulation of a subset of muscle acylcarnitines comprised of short, medium and long chain species in CAF-fed rodents compared to SC-fed controls indicative of mitochondrial dysfunction, as was also found in serum. |
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Formal Description Interaction-ID: 32038 |
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| Comment | The study showed an accumulation of a subset of muscle acylcarnitines comprised of short, medium and long chain species in CAF-fed rodents compared to SC-fed controls indicative of mitochondrial dysfunction, as was also found in serum. |
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Formal Description Interaction-ID: 32039 |
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| Comment | The study showed an accumulation of a subset of muscle acylcarnitines comprised of short, medium and long chain species in CAF-fed rodents compared to SC-fed controls indicative of mitochondrial dysfunction, as was also found in serum. |
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Formal Description Interaction-ID: 32040 |
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| Comment | The study showed an accumulation of a subset of muscle acylcarnitines comprised of short, medium and long chain species in CAF-fed rodents compared to SC-fed controls indicative of mitochondrial dysfunction, as was also found in serum. |
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Formal Description Interaction-ID: 32041 |
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| Drugbank entries | Show/Hide entries for |
| Comment | The study showed an accumulation of a subset of muscle acylcarnitines comprised of short, medium and long chain species in CAF-fed rodents compared to SC-fed controls indicative of mitochondrial dysfunction, as was also found in serum. |
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Formal Description Interaction-ID: 32042 |
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| Comment | The study showed an accumulation of a subset of muscle acylcarnitines comprised of short, medium and long chain species in CAF-fed rodents compared to SC-fed controls indicative of mitochondrial dysfunction, as was also found in serum. |
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Formal Description Interaction-ID: 32043 |
environment cafeteria diet increases_quantity of drug/chemical compound |
| Comment | The study showed an accumulation of a subset of muscle acylcarnitines comprised of short, medium and long chain species in CAF-fed rodents compared to SC-fed controls indicative of mitochondrial dysfunction, as was also found in serum. |
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Formal Description Interaction-ID: 32044 |
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| Comment | The study showed an accumulation of a subset of muscle acylcarnitines comprised of short, medium and long chain species in CAF-fed rodents compared to SC-fed controls indicative of mitochondrial dysfunction, as was also found in serum. |
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Formal Description Interaction-ID: 32050 |
environment cafeteria diet increases_quantity of drug/chemical compound Hydroxybutyrylcarnitine |
| Comment | The study showed an accumulation of a subset of muscle acylcarnitines comprised of short, medium and long chain species in CAF-fed rodents compared to SC-fed controls indicative of mitochondrial dysfunction, as was also found in serum. |
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Formal Description Interaction-ID: 32051 |
environment cafeteria diet increases_quantity of drug/chemical compound Hexanoylcarnitine |
| Comment | The study showed an accumulation of a subset of muscle acylcarnitines comprised of short, medium and long chain species in CAF-fed rodents compared to SC-fed controls indicative of mitochondrial dysfunction, as was also found in serum. |
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Formal Description Interaction-ID: 32052 |
environment cafeteria diet increases_quantity of drug/chemical compound Methylmalonylcarnitine/Succinylcarnitine |
| Comment | The study showed an accumulation of a subset of muscle acylcarnitines comprised of short, medium and long chain species in CAF-fed rodents compared to SC-fed controls indicative of mitochondrial dysfunction, as was also found in serum. |
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Formal Description Interaction-ID: 32053 |
environment cafeteria diet increases_quantity of drug/chemical compound Acylcarnitine C8:1 |
| Comment | The study showed an accumulation of a subset of muscle acylcarnitines comprised of short, medium and long chain species in CAF-fed rodents compared to SC-fed controls indicative of mitochondrial dysfunction, as was also found in serum. |
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Formal Description Interaction-ID: 32054 |
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| Comment | The study showed an accumulation of a subset of muscle acylcarnitines comprised of short, medium and long chain species in CAF-fed rodents compared to SC-fed controls indicative of mitochondrial dysfunction, as was also found in serum. |
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Formal Description Interaction-ID: 32055 |
environment cafeteria diet increases_quantity of drug/chemical compound Acylcarnitine C8:1-OH |
| Comment | The study showed an accumulation of a subset of muscle acylcarnitines comprised of short, medium and long chain species in CAF-fed rodents compared to SC-fed controls indicative of mitochondrial dysfunction, as was also found in serum. |
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Formal Description Interaction-ID: 32056 |
environment cafeteria diet increases_quantity of drug/chemical compound Acylcarnitine C6:1-DC |
| Comment | The study showed an accumulation of a subset of muscle acylcarnitines comprised of short, medium and long chain species in CAF-fed rodents compared to SC-fed controls indicative of mitochondrial dysfunction, as was also found in serum. |
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Formal Description Interaction-ID: 32057 |
environment cafeteria diet increases_quantity of drug/chemical compound Acylcarnitine C10:3 |
| Comment | The study showed an accumulation of a subset of muscle acylcarnitines comprised of short, medium and long chain species in CAF-fed rodents compared to SC-fed controls indicative of mitochondrial dysfunction, as was also found in serum. |
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Formal Description Interaction-ID: 32058 |
environment cafeteria diet increases_quantity of drug/chemical compound Acylcarnitine C10:2 |
| Comment | The study showed an accumulation of a subset of muscle acylcarnitines comprised of short, medium and long chain species in CAF-fed rodents compared to SC-fed controls indicative of mitochondrial dysfunction, as was also found in serum. |
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Formal Description Interaction-ID: 32059 |
environment cafeteria diet increases_quantity of drug/chemical compound Acylcarnitine C10:1 |
| Comment | The study showed an accumulation of a subset of muscle acylcarnitines comprised of short, medium and long chain species in CAF-fed rodents compared to SC-fed controls indicative of mitochondrial dysfunction, as was also found in serum. |
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Formal Description Interaction-ID: 32061 |
environment cafeteria diet increases_quantity of drug/chemical compound Decanoylcarnitine |
| Comment | The study showed an accumulation of a subset of muscle acylcarnitines comprised of short, medium and long chain species in CAF-fed rodents compared to SC-fed controls indicative of mitochondrial dysfunction, as was also found in serum. |
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Formal Description Interaction-ID: 32062 |
environment cafeteria diet increases_quantity of drug/chemical compound Suberoylcarnitine |
| Comment | The study showed an accumulation of a subset of muscle acylcarnitines comprised of short, medium and long chain species in CAF-fed rodents compared to SC-fed controls indicative of mitochondrial dysfunction, as was also found in serum. |
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Formal Description Interaction-ID: 32063 |
environment cafeteria diet increases_quantity of drug/chemical compound Acylcarnitine C12:1 |
| Comment | The study showed an accumulation of a subset of muscle acylcarnitines comprised of short, medium and long chain species in CAF-fed rodents compared to SC-fed controls indicative of mitochondrial dysfunction, as was also found in serum. |
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Formal Description Interaction-ID: 32064 |
environment cafeteria diet increases_quantity of drug/chemical compound Lauroylcarnitine |
| Comment | The study showed an accumulation of a subset of muscle acylcarnitines comprised of short, medium and long chain species in CAF-fed rodents compared to SC-fed controls indicative of mitochondrial dysfunction, as was also found in serum. |
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Formal Description Interaction-ID: 32065 |
environment cafeteria diet increases_quantity of drug/chemical compound Sebacoylcarnitine/3-Hydroxydodecanoylcarnitine |
| Comment | The study showed an accumulation of a subset of muscle acylcarnitines comprised of short, medium and long chain species in CAF-fed rodents compared to SC-fed controls indicative of mitochondrial dysfunction, as was also found in serum. |
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Formal Description Interaction-ID: 32067 |
environment cafeteria diet increases_quantity of drug/chemical compound Acylcarnitine C14:2 |
| Comment | The study showed an accumulation of a subset of muscle acylcarnitines comprised of short, medium and long chain species in CAF-fed rodents compared to SC-fed controls indicative of mitochondrial dysfunction, as was also found in serum. |
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Formal Description Interaction-ID: 32068 |
environment cafeteria diet increases_quantity of drug/chemical compound Acylcarnitine C14:1 |
| Comment | The study showed an accumulation of a subset of muscle acylcarnitines comprised of short, medium and long chain species in CAF-fed rodents compared to SC-fed controls indicative of mitochondrial dysfunction, as was also found in serum. |
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Formal Description Interaction-ID: 32069 |
environment cafeteria diet increases_quantity of drug/chemical compound Tetradecanoylcarnitine |
| Comment | The study showed an accumulation of a subset of muscle acylcarnitines comprised of short, medium and long chain species in CAF-fed rodents compared to SC-fed controls indicative of mitochondrial dysfunction, as was also found in serum. |
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Formal Description Interaction-ID: 32070 |
environment cafeteria diet increases_quantity of drug/chemical compound Acylcarnitine C14:1-OH |
| Comment | The study showed an accumulation of a subset of muscle acylcarnitines comprised of short, medium and long chain species in CAF-fed rodents compared to SC-fed controls indicative of mitochondrial dysfunction, as was also found in serum. |
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Formal Description Interaction-ID: 32072 |
environment cafeteria diet increases_quantity of drug/chemical compound Dodecanedioylcarnitine/3-Hydroxytetradecanoylcarnitine |
| Comment | The study showed an accumulation of a subset of muscle acylcarnitines comprised of short, medium and long chain species in CAF-fed rodents compared to SC-fed controls indicative of mitochondrial dysfunction, as was also found in serum. |
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Formal Description Interaction-ID: 32073 |
environment cafeteria diet increases_quantity of drug/chemical compound Acylcarnitine C16:2 |
| Comment | The study showed an accumulation of a subset of muscle acylcarnitines comprised of short, medium and long chain species in CAF-fed rodents compared to SC-fed controls indicative of mitochondrial dysfunction, as was also found in serum. |
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Formal Description Interaction-ID: 32074 |
environment cafeteria diet increases_quantity of drug/chemical compound Acylcarnitine C16:1 |
| Comment | The study showed an accumulation of a subset of muscle acylcarnitines comprised of short, medium and long chain species in CAF-fed rodents compared to SC-fed controls indicative of mitochondrial dysfunction, as was also found in serum. |
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Formal Description Interaction-ID: 32075 |
environment cafeteria diet increases_quantity of drug/chemical compound |
| Comment | The study showed an accumulation of a subset of muscle acylcarnitines comprised of short, medium and long chain species in CAF-fed rodents compared to SC-fed controls indicative of mitochondrial dysfunction, as was also found in serum. |
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Formal Description Interaction-ID: 32077 |
environment cafeteria diet increases_quantity of drug/chemical compound Acylcarnitine C14:1-DC/C16:1-OH |
| Comment | The study showed an accumulation of a subset of muscle acylcarnitines comprised of short, medium and long chain species in CAF-fed rodents compared to SC-fed controls indicative of mitochondrial dysfunction, as was also found in serum. |
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Formal Description Interaction-ID: 32078 |
environment cafeteria diet increases_quantity of drug/chemical compound Acylcarnitine C18:2 |
| Comment | The study showed an accumulation of a subset of muscle acylcarnitines comprised of short, medium and long chain species in CAF-fed rodents compared to SC-fed controls indicative of mitochondrial dysfunction, as was also found in serum. |
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Formal Description Interaction-ID: 32079 |
environment cafeteria diet increases_quantity of drug/chemical compound Acylcarnitine C18:1 |
| Comment | The study showed an accumulation of a subset of muscle acylcarnitines comprised of short, medium and long chain species in CAF-fed rodents compared to SC-fed controls indicative of mitochondrial dysfunction, as was also found in serum. |
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Formal Description Interaction-ID: 32080 |
environment cafeteria diet increases_quantity of drug/chemical compound Stearoylcarnitine |
| Comment | The study showed an accumulation of a subset of muscle acylcarnitines comprised of short, medium and long chain species in CAF-fed rodents compared to SC-fed controls indicative of mitochondrial dysfunction, as was also found in serum. |
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Formal Description Interaction-ID: 32081 |
environment cafeteria diet increases_quantity of drug/chemical compound Acylcarnitine C18:2-OH |
| Comment | The study showed an accumulation of a subset of muscle acylcarnitines comprised of short, medium and long chain species in CAF-fed rodents compared to SC-fed controls indicative of mitochondrial dysfunction, as was also found in serum. |
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Formal Description Interaction-ID: 32082 |
environment cafeteria diet increases_quantity of drug/chemical compound Acylcarnitine C18:1-OH |
| Comment | The study showed an accumulation of a subset of muscle acylcarnitines comprised of short, medium and long chain species in CAF-fed rodents compared to SC-fed controls indicative of mitochondrial dysfunction, as was also found in serum. |
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Formal Description Interaction-ID: 32084 |
environment cafeteria diet increases_quantity of drug/chemical compound Hexadecanedioylcarnitine/3-Hydroxyoctadecanoylcarnitine |
| Comment | Epididymal white adipose tissue (eWAT) from CAF-fed animals are inflamed and display elevations in inflammatory markers such as macrophage aggregates (crown-like structures) and elevated pro-inflammatory cytokine TNFalpha expression in the macrophage-enriched stromal-vascular fraction. |
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Formal Description Interaction-ID: 32085 |
environment cafeteria diet increases_activity of process |
| Comment | Epididymal white adipose tissue (eWAT) from CAF-fed animals are inflamed and display elevations in inflammatory markers such as macrophage aggregates (crown-like structures) and elevated pro-inflammatory cytokine TNFalpha expression in the macrophage-enriched stromal-vascular fraction. |
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Formal Description Interaction-ID: 32088 |
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| Drugbank entries | Show/Hide entries for TNF |