CIDeRplusGeneral Information:
| Id: | 3,387 (click here to show other Interactions for entry) |
| Diseases: |
Carnitine deficiency, systemic primary
- [OMIM]
Diabetes mellitus, type II - [OMIM] Insulin resistance |
| Mammalia | |
| review | |
| Reference: | Vaz FM and Wanders RJ(2002) Carnitine biosynthesis in mammals Biochem. J. Pt: 3 417-429 [PMID: 11802770] |
Interaction Information:
| Comment | HTMLA might be identical to serine hydroxymethyltransferase (SHMT; EC 2.1.2.1), since it has been shown that SHMT purified from rabbit liver acts upon HTML, yielding TMABA and glycine. SHMT catalyses the tetrahydrofolate-dependent interconversion of serine and glycine, a reaction that generates one-carbon units for methionine, thymidylate and purine biosynthesis. SHMT also catalyses the aldol cleavage of other beta-hydroxyamino acids in the absence of tetrahydrofolate, including HTML. Two isoforms of SHMT are present in eukaryotic cells: one localized in the cytoplasm and one localized in mitochondria. In humans, the gene encoding the cytosolic SHMT is located on chromosome 17p11.2, and the gene encoding the mitochondrial isoenzyme is on chromosome 12q13.2. |
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Formal Description Interaction-ID: 46099 |
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| Drugbank entries | Show/Hide entries for SHMT1 or Glycine |