General Information:

Id: 3,191
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
postmortem cortical tissue (APOE4 and non-APOE4 carriers)
article
Reference: Conejero-Goldberg C et al.(2011) Molecular signatures in post-mortem brain tissue of younger individuals at high risk for Alzheimers disease as based on APOE genotype Mol. Psychiatry 16: 836-847 [PMID: 20479757]

Interaction Information:

Comment The transcripts EGFR, CNTFR, CASP6, ZNF580, GRIA2, CTNNB1, FKBPL, LGALS1 and PSMC5 differ significantly in the APOE3 and APOE4 groups and were in key biological or signaling pathways that have relevance to AD pathogenesis.
Formal Description
Interaction-ID: 29283

gene/protein

EGFR

affects_activity of

disease

Alzheimer disease

in between-group comparisons of the APOE3 (low risk) and APOE4 (high risk) genotype groups
Drugbank entries Show/Hide entries for EGFR
Comment The transcripts EGFR, CNTFR, CASP6, ZNF580, GRIA2, CTNNB1, FKBPL, LGALS1 and PSMC5 differ significantly in the APOE3 and APOE4 groups and were in key biological or signaling pathways that have relevance to AD pathogenesis.
Formal Description
Interaction-ID: 29284

gene/protein

CNTFR

affects_activity of

disease

Alzheimer disease

in between-group comparisons of the APOE3 (low risk) and APOE4 (high risk) genotype groups
Comment The transcripts EGFR, CNTFR, CASP6, ZNF580, GRIA2, CTNNB1, FKBPL, LGALS1 and PSMC5 differ significantly in the APOE3 and APOE4 groups and were in key biological or signaling pathways that have relevance to AD pathogenesis.
Formal Description
Interaction-ID: 29285

gene/protein

CASP6

affects_activity of

disease

Alzheimer disease

in between-group comparisons of the APOE3 (low risk) and APOE4 (high risk) genotype groups
Comment The transcripts EGFR, CNTFR, CASP6, ZNF580, GRIA2, CTNNB1, FKBPL, LGALS1 and PSMC5 differ significantly in the APOE3 and APOE4 groups and were in key biological or signaling pathways that have relevance to AD pathogenesis.
Formal Description
Interaction-ID: 29286

gene/protein

GRIA2

affects_activity of

disease

Alzheimer disease

in between-group comparisons of the APOE3 (low risk) and APOE4 (high risk) genotype groups
Drugbank entries Show/Hide entries for GRIA2
Comment The transcripts EGFR, CNTFR, CASP6, ZNF580, GRIA2, CTNNB1, FKBPL, LGALS1 and PSMC5 differ significantly in the APOE3 and APOE4 groups and were in key biological or signaling pathways that have relevance to AD pathogenesis.
Formal Description
Interaction-ID: 29287

gene/protein

CTNNB1

affects_activity of

disease

Alzheimer disease

in between-group comparisons of the APOE3 (low risk) and APOE4 (high risk) genotype groups
Drugbank entries Show/Hide entries for CTNNB1
Comment APOE variants differed in multiple transcripts and multiple biological pathways, including those affecting calcium regulation, cell-cycle reentry and apoptosis, mitochondrial function and transcription factors.
Formal Description
Interaction-ID: 29288

gene/protein mutant

APOE-mut

affects_expression of

gene/protein

EGFR

in between-group comparisons of the APOE3 (low risk) and APOE4 (high risk) genotype groups
Drugbank entries Show/Hide entries for EGFR
Comment The transcripts EGFR, CNTFR, CASP6, ZNF580, GRIA2, CTNNB1, FKBPL, LGALS1 and PSMC5 differ significantly in the APOE3 and APOE4 groups and were in key biological or signaling pathways that have relevance to AD pathogenesis.
Formal Description
Interaction-ID: 29289

gene/protein

ZNF580

affects_activity of

disease

Alzheimer disease

in between-group comparisons of the APOE3 (low risk) and APOE4 (high risk) genotype groups
Comment The transcripts EGFR, CNTFR, CASP6, ZNF580, GRIA2, CTNNB1, FKBPL, LGALS1 and PSMC5 differ significantly in the APOE3 and APOE4 groups and were in key biological or signaling pathways that have relevance to AD pathogenesis.
Formal Description
Interaction-ID: 29290

gene/protein

FKBPL

affects_activity of

disease

Alzheimer disease

in between-group comparisons of the APOE3 (low risk) and APOE4 (high risk) genotype groups
Comment The transcripts EGFR, CNTFR, CASP6, ZNF580, GRIA2, CTNNB1, FKBPL, LGALS1 and PSMC5 differ significantly in the APOE3 and APOE4 groups and were in key biological or signaling pathways that have relevance to AD pathogenesis.
Formal Description
Interaction-ID: 29291

gene/protein

LGALS1

affects_activity of

disease

Alzheimer disease

in between-group comparisons of the APOE3 (low risk) and APOE4 (high risk) genotype groups
Drugbank entries Show/Hide entries for LGALS1
Comment The transcripts EGFR, CNTFR, CASP6, ZNF580, GRIA2, CTNNB1, FKBPL, LGALS1 and PSMC5 differ significantly in the APOE3 and APOE4 groups and were in key biological or signaling pathways that have relevance to AD pathogenesis.
Formal Description
Interaction-ID: 29292

gene/protein

PSMC5

affects_activity of

disease

Alzheimer disease

in between-group comparisons of the APOE3 (low risk) and APOE4 (high risk) genotype groups
Comment APOE variants differed in multiple transcripts and multiple biological pathways, including those affecting calcium regulation, cell-cycle reentry and apoptosis, mitochondrial function and transcription factors.
Formal Description
Interaction-ID: 29293

gene/protein mutant

APOE-mut

affects_expression of

gene/protein

CNTFR

in between-group comparisons of the APOE3 (low risk) and APOE4 (high risk) genotype groups
Comment APOE variants differed in multiple transcripts and multiple biological pathways, including those affecting calcium regulation, cell-cycle reentry and apoptosis, mitochondrial function and transcription factors.
Formal Description
Interaction-ID: 29294

gene/protein mutant

APOE-mut

affects_expression of

gene/protein

CASP6

in between-group comparisons of the APOE3 (low risk) and APOE4 (high risk) genotype groups
Comment APOE variants differed in multiple transcripts and multiple biological pathways, including those affecting calcium regulation, cell-cycle reentry and apoptosis, mitochondrial function and transcription factors.
Formal Description
Interaction-ID: 29295

gene/protein mutant

APOE-mut

affects_expression of

gene/protein

GRIA2

in between-group comparisons of the APOE3 (low risk) and APOE4 (high risk) genotype groups
Drugbank entries Show/Hide entries for GRIA2
Comment APOE variants differed in multiple transcripts and multiple biological pathways, including those affecting calcium regulation, cell-cycle reentry and apoptosis, mitochondrial function and transcription factors.
Formal Description
Interaction-ID: 29296

gene/protein mutant

APOE-mut

affects_expression of

gene/protein

CTNNB1

in between-group comparisons of the APOE3 (low risk) and APOE4 (high risk) genotype groups
Drugbank entries Show/Hide entries for CTNNB1
Comment APOE variants differed in multiple transcripts and multiple biological pathways, including those affecting calcium regulation, cell-cycle reentry and apoptosis, mitochondrial function and transcription factors.
Formal Description
Interaction-ID: 29297

gene/protein mutant

APOE-mut

affects_expression of

gene/protein

FKBPL

in between-group comparisons of the APOE3 (low risk) and APOE4 (high risk) genotype groups
Comment APOE variants differed in multiple transcripts and multiple biological pathways, including those affecting calcium regulation, cell-cycle reentry and apoptosis, mitochondrial function and transcription factors.
Formal Description
Interaction-ID: 29298

gene/protein mutant

APOE-mut

affects_expression of

gene/protein

LGALS1

in between-group comparisons of the APOE3 (low risk) and APOE4 (high risk) genotype groups
Drugbank entries Show/Hide entries for LGALS1
Comment APOE variants differed in multiple transcripts and multiple biological pathways, including those affecting calcium regulation, cell-cycle reentry and apoptosis, mitochondrial function and transcription factors.
Formal Description
Interaction-ID: 29299

gene/protein mutant

APOE-mut

affects_expression of

gene/protein

PSMC5

in between-group comparisons of the APOE3 (low risk) and APOE4 (high risk) genotype groups
Comment APOE variants differed in multiple transcripts and multiple biological pathways, including those affecting calcium regulation, cell-cycle reentry and apoptosis, mitochondrial function and transcription factors.
Formal Description
Interaction-ID: 29300

gene/protein mutant

APOE-mut

affects_expression of

gene/protein

ZNF580

in between-group comparisons of the APOE3 (low risk) and APOE4 (high risk) genotype groups
Comment The transcripts EGFR, CNTFR, CASP6, ZNF580, GRIA2, CTNNB1, FKBPL, LGALS1 and PSMC5 differ significantly in the APOE3 and APOE4 groups and were in key biological or signaling pathways that have relevance to AD pathogenesis.
Formal Description
Interaction-ID: 29303

gene/protein mutant

APOE-mut

affects_activity of

disease

Alzheimer disease

in between-group comparisons of the APOE3 (low risk) and APOE4 (high risk) genotype groups
Comment The transcripts EGFR, CNTFR, CASP6, ZNF580, GRIA2, CTNNB1, FKBPL, LGALS1 and PSMC5 differ significantly in the APOE3 and APOE4 groups and were in key biological or signaling pathways that have relevance to AD pathogenesis.
Formal Description
Interaction-ID: 118842

gene/protein mutant

APOE-mut

affects_expression of

gene/protein

CASP6

the transcript CASP6 differs significantly in the APOE3 and APOE4 groups
Comment CASP6 is involved in programmed cell death. It is strongly upregulated in the temporal cortex of the APOE4 group, while modestly downregulated in the primary somatosensory cortex of the APOE4 group. This may represent a response in the APOE4 group that confers susceptibility to AD pathology.
Formal Description
Interaction-ID: 118868

gene/protein

CASP6

affects_activity of

process

programmed cell death

Comment CASP6 is involved in programmed cell death. It is strongly upregulated in the temporal cortex of the APOE4 group, while modestly downregulated in the primary somatosensory cortex of the APOE4 group. This may represent a response in the APOE4 group that confers susceptibility to AD pathology.
Formal Description
Interaction-ID: 118869

gene/protein mutant

APOE (isoform E4)

increases_expression of

gene/protein

CASP6

in the temporal cortex of the APOE4 group; strongly upregulated
Comment CASP6 is involved in programmed cell death. It is strongly upregulated in the temporal cortex of the APOE4 group, while modestly downregulated in the primary somatosensory cortex of the APOE4 group. This may represent a response in the APOE4 group that confers susceptibility to AD pathology.
Formal Description
Interaction-ID: 118870

gene/protein mutant

APOE (isoform E4)

decreases_expression of

gene/protein

CASP6

in the primary somatosensory cortex of the APOE4 group; modestely downregulated