General Information:

Id: 3,081 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
BTO:0003704 H4 neuroglioma cell
article
Reference: Samy AS and Igwe OJ(2012) Regulation of IL-1beta-induced cyclooxygenase-2 expression by interactions of Abeta peptide, apolipoprotein E and nitric oxide in human neuroglioma J. Mol. Neurosci. 47: 533-545 [PMID: 22101739]

Interaction Information:

Comment After co-incubation with apoE4, Abeta (40) increased IL-1beta-induced COX-2 expression and PGE2 production.
Formal Description
Interaction-ID: 28303

gene/protein mutant

APOE (isoform E4)

affects_activity of

gene/protein

Amyloid beta peptide (40)

Comment Abeta (12-28), which binds with high affinity to apoE4, blocked apoE4-mediated effects on Abeta (40)
Formal Description
Interaction-ID: 28308

gene/protein

Amyloid beta peptide (12-28)

interacts (colocalizes) with

gene/protein mutant

APOE (isoform E4)

Comment Increased PGE2 resulted from increased nitrosative stress, which is enhanced by apoE4.
Formal Description
Interaction-ID: 28341

gene/protein mutant

APOE (isoform E4)

increases_activity of

process

response to nitrosative stress