CIDeRplusGeneral Information:
| Id: | 3,081 |
| Diseases: |
Alzheimer disease
- [OMIM]
|
| Homo sapiens | |
| BTO:0003704 H4 neuroglioma cell | |
| article | |
| Reference: | Samy AS and Igwe OJ(2012) Regulation of IL-1beta-induced cyclooxygenase-2 expression by interactions of Abeta peptide, apolipoprotein E and nitric oxide in human neuroglioma J. Mol. Neurosci. 47: 533-545 [PMID: 22101739] |
Interaction Information:
| Comment | After co-incubation with apoE4, Abeta (40) increased IL-1beta-induced COX-2 expression and PGE2 production. |
|
Formal Description Interaction-ID: 28303 |
|
| Comment | After co-incubation with apoE4, Abeta (40) increased IL-1beta-induced COX-2 expression and PGE2 production. |
|
Formal Description Interaction-ID: 28305 |
gene/protein increases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for PTGS2 |
| Comment | After co-incubation with apoE4, Abeta (40) increased IL-1beta-induced COX-2 expression and PGE2 production. |
|
Formal Description Interaction-ID: 28306 |
gene/protein increases_quantity of drug/chemical compound |
| Comment | Abeta (12-28), which binds with high affinity to apoE4, blocked apoE4-mediated effects on Abeta (40) |
|
Formal Description Interaction-ID: 28308 |
gene/protein interacts (colocalizes) with gene/protein mutant |
| Comment | Abeta (12-28), which binds with high affinity to apoE4, blocked apoE4-mediated effects on Abeta (40) |
|
Formal Description Interaction-ID: 28309 |
gene/protein affects_activity of gene/protein |
| Comment | (+-)-S-Nitroso-N-acetylpenicillamine (SNAP) increased PGE2 production. |
|
Formal Description Interaction-ID: 28337 |
drug/chemical compound S-Nitroso-N-acetylpenicillamine increases_quantity of drug/chemical compound |
| Comment | (+-)-S-Nitroso-N-acetylpenicillamine (SNAP) releases nitric oxide (NO) |
|
Formal Description Interaction-ID: 28338 |
drug/chemical compound S-Nitroso-N-acetylpenicillamine increases_quantity of drug/chemical compound |
| Comment | (+-)-S-Nitroso-N-acetylpenicillamine (SNAP) alone did not affect IL-1beta-induced COX-2 expression. |
|
Formal Description Interaction-ID: 28339 |
drug/chemical compound S-Nitroso-N-acetylpenicillamine NOT affects_activity of gene/protein |
| Drugbank entries | Show/Hide entries for PTGS2 |
| Comment | Increased PGE2 resulted from increased nitrosative stress, which is enhanced by apoE4. |
|
Formal Description Interaction-ID: 28340 |
process increases_quantity of drug/chemical compound |
| Comment | Increased PGE2 resulted from increased nitrosative stress, which is enhanced by apoE4. |
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Formal Description Interaction-ID: 28341 |
|
| Comment | High levels of NO (nitric oxide) increase the activity of nitrosative stress. |
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Formal Description Interaction-ID: 28342 |
|