General Information:

Id: 3,079 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
BTO:0000007 HEK-293 cell
article
Reference: Xue Y et al.(2011) Crystal structure of the E2 domain of amyloid precursor protein-like protein 1 in complex with sucrose octasulfate. J. Biol. Chem. 286 [PMID: 21715329]

Interaction Information:

Comment Endogenous heparan sulfate (HS) influenced Abeta production primarily through its direct inhibition of beta-secretase.
Formal Description
Interaction-ID: 28300

drug/chemical compound

Heparan sulfate

decreases_quantity of

gene/protein

Amyloid beta peptide

via direct inhibition of beta-secretase